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Results: 1 to 20 of 28

1.

Disposition and metabolism of LY2603618, a Chk-1 inhibitor following intravenous administration in patients with advanced and/or metastatic solid tumors.

Wickremsinhe ER, Hynes SM, Palmieri MD, Mitchell MI, Abraham TL, Rehmel JF, Chana E, Jost LM, Cassidy KC.

Xenobiotica. 2014 Mar 26. [Epub ahead of print]

PMID:
24666335
[PubMed - as supplied by publisher]
2.

Effects of duloxetine on norepinephrine and serotonin transporter activity in healthy subjects.

Chappell JC, Eisenhofer G, Owens MJ, Haber H, Lachno DR, Dean RA, Knadler MP, Nemeroff CB, Mitchell MI, Detke MJ, Iyengar S, Pangallo B, Lobo ED.

J Clin Psychopharmacol. 2014 Feb;34(1):9-16. doi: 10.1097/JCP.0000000000000061.

PMID:
24346757
[PubMed - in process]
3.

The effect of hepatic or renal impairment on the pharmacokinetics of edivoxetine, a selective norepinephrine transporter reuptake inhibitor.

Kielbasa W, Tesfaye E, Luffer-Atlas D, Mitchell MI, Turik MA.

Eur J Clin Pharmacol. 2013 Dec;69(12):2011-9. doi: 10.1007/s00228-013-1572-y. Epub 2013 Aug 17.

PMID:
23955175
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Evaluation of the effects of duloxetine and escitalopram on 24-hour heart rate variability: a mechanistic study using heart rate variability as a pharmacodynamic measure.

Chappell JC, Kovacs R, Haber H, Wright R, Mitchell MI, Detke M, Pangallo B.

J Clin Psychopharmacol. 2013 Apr;33(2):236-9. doi: 10.1097/JCP.0b013e31828567b6.

PMID:
23422380
[PubMed - indexed for MEDLINE]
5.

Effects of atomoxetine on the QT interval in healthy CYP2D6 poor metabolizers.

Loghin C, Haber H, Beasley CM Jr, Kothare PA, Kauffman L, April J, Jin L, Allen AJ, Mitchell MI.

Br J Clin Pharmacol. 2013 Feb;75(2):538-49. doi: 10.1111/j.1365-2125.2012.04382.x.

PMID:
22803597
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Effect of exenatide on the pharmacokinetics of a combination oral contraceptive in healthy women: an open-label, randomised, crossover trial.

Kothare PA, Seger ME, Northrup J, Mace K, Mitchell MI, Linnebjerg H.

BMC Clin Pharmacol. 2012 Mar 19;12:8. doi: 10.1186/1472-6904-12-8.

PMID:
22429273
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

A thorough QT study to evaluate the effects of singledose exenatide 10 μg on cardiac repolarization in healthy subjects.

Linnebjerg H, Seger M, Kothare PA, Hunt T, Wolka AM, Mitchell MI.

Int J Clin Pharmacol Ther. 2011 Oct;49(10):594-604.

PMID:
21961484
[PubMed - indexed for MEDLINE]
8.

Evaluation of methods for achieving stable INR in healthy subjects during a multiple-dose warfarin study.

Chappell JC, Dickinson G, Mitchell MI, Haber H, Jin Y, Lobo ED.

Eur J Clin Pharmacol. 2012 Mar;68(3):239-47. doi: 10.1007/s00228-011-1114-4. Epub 2011 Sep 1.

PMID:
21881887
[PubMed - indexed for MEDLINE]
9.

Systematic decrements in QTc between the first and second day of contiguous daily ECG recordings under controlled conditions.

Beasley CM Jr, Benson C, Xia JQ, Young SS, Haber H, Mitchell MI, Loghin C.

Pacing Clin Electrophysiol. 2011 Sep;34(9):1116-27. doi: 10.1111/j.1540-8159.2011.03117.x. Epub 2011 Apr 28.

PMID:
21535038
[PubMed - indexed for MEDLINE]
10.

Exenatide - pharmacokinetics, pharmacodynamics, safety and tolerability in patients ≥ 75 years of age with Type 2 diabetes.

Linnebjerg H, Kothare PA, Seger M, Wolka AM, Mitchell MI.

Int J Clin Pharmacol Ther. 2011 Feb;49(2):99-108.

PMID:
21255526
[PubMed - indexed for MEDLINE]
11.

Post-injection delirium/sedation syndrome in patients with schizophrenia treated with olanzapine long-acting injection, II: investigations of mechanism.

McDonnell DP, Detke HC, Bergstrom RF, Kothare P, Johnson J, Stickelmeyer M, Sanchez-Felix MV, Sorsaburu S, Mitchell MI.

BMC Psychiatry. 2010 Jun 10;10:45. doi: 10.1186/1471-244X-10-45.

PMID:
20537130
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Design and analysis considerations for thorough QT studies employing conventional (10 s, 12-lead) ECG recordings.

Beasley CM Jr, Dmitrienko A, Mitchell MI.

Expert Rev Clin Pharmacol. 2008 Nov;1(6):815-39. doi: 10.1586/17512433.1.6.815.

PMID:
24410610
[PubMed]
13.

Pharmacokinetic interaction between tadalafil and bosentan in healthy male subjects.

Wrishko RE, Dingemanse J, Yu A, Darstein C, Phillips DL, Mitchell MI.

J Clin Pharmacol. 2008 May;48(5):610-8. doi: 10.1177/0091270008315315. Epub 2008 Feb 27.

PMID:
18305126
[PubMed - indexed for MEDLINE]
14.

Hemodynamic interaction between a daily dosed phosphodiesterase 5 inhibitor, tadalafil, and the alpha-adrenergic blockers, doxazosin and tamsulosin, in middle-aged healthy male subjects.

Guillaume M, Lonsdale F, Darstein C, Jimenez MC, Mitchell MI.

J Clin Pharmacol. 2007 Oct;47(10):1303-10.

PMID:
17906163
[PubMed - indexed for MEDLINE]
15.

The effects of supratherapeutic doses of duloxetine on blood pressure and pulse rate.

Derby MA, Zhang L, Chappell JC, Gonzales CR, Callaghan JT, Leibowitz M, Ereshefsky L, Hoelscher D, Leese PT, Mitchell MI.

J Cardiovasc Pharmacol. 2007 Jun;49(6):384-93.

PMID:
17577103
[PubMed - indexed for MEDLINE]
16.

Effects of gender, age, diabetes mellitus and renal and hepatic impairment on tadalafil pharmacokinetics.

Forgue ST, Phillips DL, Bedding AW, Payne CD, Jewell H, Patterson BE, Wrishko RE, Mitchell MI.

Br J Clin Pharmacol. 2007 Jan;63(1):24-35. Epub 2006 Jul 21.

PMID:
16869816
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Tadalafil pharmacokinetics in healthy subjects.

Forgue ST, Patterson BE, Bedding AW, Payne CD, Phillips DL, Wrishko RE, Mitchell MI.

Br J Clin Pharmacol. 2006 Mar;61(3):280-8.

PMID:
16487221
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The combined use of ibutilide as an active control with intensive electrocardiographic sampling and signal averaging as a sensitive method to assess the effects of tadalafil on the human QT interval.

Beasley CM Jr, Mitchell MI, Dmitrienko AA, Emmick JT, Shen W, Costigan TM, Bedding AW, Turik MA, Bakhtyari A, Warner MR, Ruskin JN, Cantilena LR Jr, Kloner RA.

J Am Coll Cardiol. 2005 Aug 16;46(4):678-87.

PMID:
16098435
[PubMed - indexed for MEDLINE]
Free Article
19.

Effect of tadalafil on cytochrome P450 3A4-mediated clearance: studies in vitro and in vivo.

Ring BJ, Patterson BE, Mitchell MI, Vandenbranden M, Gillespie J, Bedding AW, Jewell H, Payne CD, Forgue ST, Eckstein J, Wrighton SA, Phillips DL.

Clin Pharmacol Ther. 2005 Jan;77(1):63-75.

PMID:
15637532
[PubMed - indexed for MEDLINE]
20.

Interaction between the phosphodiesterase 5 inhibitor, tadalafil and 2 alpha-blockers, doxazosin and tamsulosin in healthy normotensive men.

Kloner RA, Jackson G, Emmick JT, Mitchell MI, Bedding A, Warner MR, Pereira A.

J Urol. 2004 Nov;172(5 Pt 1):1935-40.

PMID:
15540759
[PubMed - indexed for MEDLINE]

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