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Results: 16


Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice.

Mingueneau M, Krishnaswamy S, Spitzer MH, Bendall SC, Stone EL, Hedrick SM, Pe'er D, Mathis D, Nolan GP, Benoist C.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16466-71. doi: 10.1073/pnas.1419337111. Epub 2014 Oct 31.


Systems biology. Conditional density-based analysis of T cell signaling in single-cell data.

Krishnaswamy S, Spitzer MH, Mingueneau M, Bendall SC, Litvin O, Stone E, Pe'er D, Nolan GP.

Science. 2014 Nov 28;346(6213):1250689. doi: 10.1126/science.1250689. Epub 2014 Oct 23.


The transcriptional landscape of αβ T cell differentiation.

Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C; Immunological Genome Consortium, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Nageswara Rao T, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S.

Nat Immunol. 2013 Jun;14(6):619-32. doi: 10.1038/ni.2590. Epub 2013 May 5.


Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation.

Best JA, Blair DA, Knell J, Yang E, Mayya V, Doedens A, Dustin ML, Goldrath AW; Immunological Genome Project Consortium.

Nat Immunol. 2013 Apr;14(4):404-12. doi: 10.1038/ni.2536. Epub 2013 Feb 10.


Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.

Cohen NR, Brennan PJ, Shay T, Watts GF, Brigl M, Kang J, Brenner MB; ImmGen Project Consortium.

Nat Immunol. 2013 Jan;14(1):90-9. doi: 10.1038/ni.2490. Epub 2012 Dec 2.


Consortium biology in immunology: the perspective from the Immunological Genome Project.

Benoist C, Lanier L, Merad M, Mathis D; Immunological Genome Project.

Nat Rev Immunol. 2012 Oct;12(10):734-40. doi: 10.1038/nri3300. Epub 2012 Sep 7. Erratum in: Nat Rev Immunol. 2014 Aug;14(8):578. Cipoletta, Daniela [corrected to Cipolletta, Daniela].


Thymic negative selection is functional in NOD mice.

Mingueneau M, Jiang W, Feuerer M, Mathis D, Benoist C.

J Exp Med. 2012 Mar 12;209(3):623-37. doi: 10.1084/jem.20112593. Epub 2012 Feb 13.


LAT signaling pathology: an "autoimmune" condition without T cell self-reactivity.

Roncagalli R, Mingueneau M, Grégoire C, Malissen M, Malissen B.

Trends Immunol. 2010 Jul;31(7):253-9. doi: 10.1016/ Epub 2010 Jun 9. Review.


Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development.

Wang H, Holst J, Woo SR, Guy C, Bettini M, Wang Y, Shafer A, Naramura M, Mingueneau M, Dragone LL, Hayes SM, Malissen B, Band H, Vignali DA.

EMBO J. 2010 Apr 7;29(7):1285-98. doi: 10.1038/emboj.2010.10. Epub 2010 Feb 11.


Lymphoproliferative disorders involving T helper effector cells with defective LAT signalosomes.

Roncagalli R, Mingueneau M, Grégoire C, Langlet C, Malissen B, Malissen M.

Semin Immunopathol. 2010 Jun;32(2):117-25. doi: 10.1007/s00281-009-0195-y. Epub 2010 Jan 28. Review.


Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.

Mingueneau M, Roncagalli R, Grégoire C, Kissenpfennig A, Miazek A, Archambaud C, Wang Y, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B.

Immunity. 2009 Aug 21;31(2):197-208. doi: 10.1016/j.immuni.2009.05.013. Epub 2009 Aug 13.


STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat(Y136F) mice into a lymphoproliferative disorder involving Th1 and CD8 effector T cells.

Archambaud C, Sansoni A, Mingueneau M, Devilard E, Delsol G, Malissen B, Malissen M.

J Immunol. 2009 Mar 1;182(5):2680-9. doi: 10.4049/jimmunol.0803257.


The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes.

Mingueneau M, Sansoni A, Grégoire C, Roncagalli R, Aguado E, Weiss A, Malissen M, Malissen B.

Nat Immunol. 2008 May;9(5):522-32. doi: 10.1038/ni.1608. Epub 2008 Apr 13.


Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells.

Wang Y, Kissenpfennig A, Mingueneau M, Richelme S, Perrin P, Chevrier S, Genton C, Lucas B, DiSanto JP, Acha-Orbea H, Malissen B, Malissen M.

J Immunol. 2008 Feb 1;180(3):1565-75.


Th2 lymphoproliferative disorders resulting from defective LAT signalosomes.

Malissen B, Wang Y, Mingueneau M, Malissen M.

Novartis Found Symp. 2007;281:93-100; discussion 100-2, 208-9. Review.


Multiplicity and plasticity of natural killer cell signaling pathways.

Chiesa S, Mingueneau M, Fuseri N, Malissen B, Raulet DH, Malissen M, Vivier E, Tomasello E.

Blood. 2006 Mar 15;107(6):2364-72. Epub 2005 Nov 15.

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