Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Clin Cardiol. 2012 Aug;35(8):451-7. doi: 10.1002/clc.22005. Epub 2012 May 31.

Atherothrombotic disease, traditional risk factors, and 4-year mortality in a Latin American population: the REACH Registry.

Collaborators (159)

Acevedo M, Araya F, Barrientos N, Blanchi V, Chavez E, Corbalán R, Diaz R, Dighero H, Garayar B, Garjardo L, Garrido B, Gutierrez V, Hoppe A, Kauffmann R, Kramer A, Kunstmann S, Manriquez L, Srur EM, Tapia J, Varleta PE, Villar RA, Arango AC, Arauz J, Benzadon A, Cabrera JR, Cantisano L, Castillo B, Chavez EH, Chen CH, Diaz E, Dina RE, Espinosa H, Hernandez D, Hernandez J, Lopez R, Madrid JL, Medine FP, Minchola JA, Mini M, Molina G, Motta J, Moya J, Ortiz ME, Parajeles A, Ramos CA, Rodriguez E, Saravia GL, Sprok JM, Tortos-Guzman J, Urrutia V, Veras D, Vercauteren JP, Villa-Garcin P, Vinocour M, Albuquerque D, Atai de L Jr, Atie J, Avezum A, Bandeira F, Bodanese L, Brasileiro A, Carvalho AC, Dutra O, Esporcatte R, Esteves JP, Eugenio AM, Feitosa G, Fernandes J, Halpern A, Knobel M, Lopes C, Lyra R, Machado N, Maciel L, Marino R, Massaro A, Matos A, Mesquita E, Moreira M, Nagato YN, Nicolau JC, Nogueira PR, Pazin-Filho A, Pires MT, Rocha A, Rocha R, Saraiva JF, Schmid H, Serro J, Tambascia M, Xavier SS, Yamamoto F, Yoshida WB, Zanella MT, Abundes A, Aguayo G, Alegría MA, Alexanderson G, Alpizar M, Amaya LE, Arauz A, Astorga A, Azpiri JR, Barinagarrementeria F, Benavides MA, Bernal E, Briseño HM, Caluo C, Cantú-Brito C, Cedillo FR, Colorado H, Cortes J, Cossio J, Ríos MO, De Zatarain R, Díaz C, Eng L, Esparragoza J, Espinosa L, Espinoza C, Fernández P, García E, García R, Garza A, Gaxiola E, González FJ, Guerrero F, Herududez I, Kostine A, Leiva JL, Llamas-López L, López B, López J, López M, Marcos A, Najar S, Nettel J, Ortiz F, Peralta R, Pérez JC, Ranero A, Rangel-Guerra R, Rodríguez J, Rodríguez L, Rojas JA, Romero A, Rubio G, Ruiz JL, Sagastegui A, Talamas O, Tapia M, Toriz JL, Uribe A, Vázquez J, Velasco JA, Velasco EC, Velasco-Sanchez RG, Villarreal J, Alcocer MA.

Author information

  • 1Department of Neurology and Psychiatry, Salvador Zubirán National Institute of Medical Sciences and Nutrition, Mexico City, Mexico. carloscantu_brito@hotmail.com

Abstract

BACKGROUND:

Atherothrombosis is becoming the leading cause of chronic morbidity in developing countries. This epidemiological transition will represent an unbearable socioeconomic burden in the near future. We investigated factors associated with 4-year all-cause mortality in a Latin American population at high risk.

HYPOTHESIS:

Largely modifiable risk factors as well as polyvascular disease are the main predictors of 4-year all-cause and cardiovascular mortality in this Latin American cohort.

METHODS:

We analyzed 1816 Latin American stable outpatients (62.3% men, mean age 67 years) with symptomatic atherothrombosis (87.1%) or with multiple risk factors only (12.9%), in the Reduction of Atherothrombosis for Continued Health registry.

RESULTS:

Of patients with symptomatic atherothrombosis, 57.3% had coronary artery disease, 32% cerebrovascular disease, and 11.7% peripheral artery disease at baseline (9.1% polyvascular). The main risk factors were hypertension (76%), hypercholesterolemia (60%), and smoking (52.3%) in patients with established atherothrombosis; and hypertension (89.7%), diabetes (80.8%), and hypercholesterolemia (73.9%) in those with risk factors only. Four-year all-cause mortality steeply increased with none (6.8%), 1 (9.2%), 2 (15.5%), and 3 (29.2%) symptomatic arterial disease locations. In patients with only 1 location, cardiovascular mortality was significantly higher with peripheral artery disease (11.3%) than with cerebrovascular disease (6%) or coronary artery disease (5.1%). Significant baseline predictors of 4-year all-cause mortality were congestive heart failure (hazard ratio [HR]: 3.81), body mass index <20 (HR: 2.32), hypertension (HR: 1.84), polyvascular disease (HR: 1.69), and age ≥ 65 years (HR: 1.47), whereas statin use (HR: 0.49) and body mass index ≥ 30 (HR: 0.58) were associated with a reduced risk.

CONCLUSIONS:

Hypertension was the main modifiable risk factor for atherothrombosis and all-cause mortality in this Latin American cohort. Nearly one-third of the population with 3 symptomatic vascular-disease locations died at 4-year follow-up.

© 2012 Wiley Periodicals, Inc.

PMID:
22653654
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk