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Role of a novel HLA-DQA1*01:02;DRB1*15:01 mixed-isotype heterodimer in the pathogenesis of 'humanized' multiple sclerosis-like disease.

Kaushansky N, Eisenstein M, Boura-Halfon S, Hansen BE, Nielsen CH, Milo R, Zeilig G, Lassmann H, Altmann DM, Ben-Nun A.

J Biol Chem. 2015 Apr 24. pii: jbc.M115.641209. [Epub ahead of print]


An in vivo metabolic approach for deciphering the product specificity of glycerate kinase proves that both E. coli's glycerate kinases generate 2-phosphoglycerate.

Zelcbuch L, Razo-Mejia M, Herz E, Yahav S, Antonovsky N, Kroytoro H, Milo R, Bar-Even A.

PLoS One. 2015 Mar 30;10(3):e0122957. doi: 10.1371/journal.pone.0122957. eCollection 2015.


Reply to Tichenor: Proposed update to beef greenhouse gas footprint is numerically questionable and well within current uncertainty bounds.

Eshel G, Shepon A, Makov T, Milo R.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):E822-3. doi: 10.1073/pnas.1422670112. Epub 2015 Feb 4. No abstract available.


Effectiveness of multiple sclerosis treatment with current immunomodulatory drugs.

Milo R.

Expert Opin Pharmacother. 2015 Apr;16(5):659-73. doi: 10.1517/14656566.2015.1002769. Epub 2015 Jan 13.


Reply to Metson et al.: The importance of phosphorus perturbations.

Eshel G, Shepon A, Makov T, Milo R.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4908. doi: 10.1073/pnas.1418658111. Epub 2014 Nov 10. No abstract available.


The quantified cell.

Flamholz A, Phillips R, Milo R.

Mol Biol Cell. 2014 Nov 5;25(22):3497-500. doi: 10.1091/mbc.E14-09-1347.


Land, irrigation water, greenhouse gas, and reactive nitrogen burdens of meat, eggs, and dairy production in the United States.

Eshel G, Shepon A, Makov T, Milo R.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):11996-2001. doi: 10.1073/pnas.1402183111. Epub 2014 Jul 21.


Visual account of protein investment in cellular functions.

Liebermeister W, Noor E, Flamholz A, Davidi D, Bernhardt J, Milo R.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8488-93. doi: 10.1073/pnas.1314810111. Epub 2014 Jun 2.


Noise genetics: inferring protein function by correlating phenotype with protein levels and localization in individual human cells.

Farkash-Amar S, Zimmer A, Eden E, Cohen A, Geva-Zatorsky N, Cohen L, Milo R, Sigal A, Danon T, Alon U.

PLoS Genet. 2014 Mar 6;10(3):e1004176. doi: 10.1371/journal.pgen.1004176. eCollection 2014 Mar.


Pathway thermodynamics highlights kinetic obstacles in central metabolism.

Noor E, Bar-Even A, Flamholz A, Reznik E, Liebermeister W, Milo R.

PLoS Comput Biol. 2014 Feb 20;10(2):e1003483. doi: 10.1371/journal.pcbi.1003483. eCollection 2014 Feb.


Revised diagnostic criteria of multiple sclerosis.

Milo R, Miller A.

Autoimmun Rev. 2014 Apr-May;13(4-5):518-24. doi: 10.1016/j.autrev.2014.01.012. Epub 2014 Jan 12. Review.


The efficacy and safety of daclizumab and its potential role in the treatment of multiple sclerosis.

Milo R.

Ther Adv Neurol Disord. 2014 Jan;7(1):7-21. doi: 10.1177/1756285613504021. Review.


Promoters maintain their relative activity levels under different growth conditions.

Keren L, Zackay O, Lotan-Pompan M, Barenholz U, Dekel E, Sasson V, Aidelberg G, Bren A, Zeevi D, Weinberger A, Alon U, Milo R, Segal E.

Mol Syst Biol. 2013 Oct 29;9:701. doi: 10.1038/msb.2013.59.


What is the total number of protein molecules per cell volume? A call to rethink some published values.

Milo R.

Bioessays. 2013 Dec;35(12):1050-5. doi: 10.1002/bies.201300066. Epub 2013 Sep 20.


Steady-state metabolite concentrations reflect a balance between maximizing enzyme efficiency and minimizing total metabolite load.

Tepper N, Noor E, Amador-Noguez D, Haraldsdóttir HS, Milo R, Rabinowitz J, Liebermeister W, Shlomi T.

PLoS One. 2013 Sep 26;8(9):e75370. doi: 10.1371/journal.pone.0075370. eCollection 2013.


A note on the kinetics of enzyme action: a decomposition that highlights thermodynamic effects.

Noor E, Flamholz A, Liebermeister W, Bar-Even A, Milo R.

FEBS Lett. 2013 Sep 2;587(17):2772-7. doi: 10.1016/j.febslet.2013.07.028. Epub 2013 Jul 23. Review.


Consistent estimation of Gibbs energy using component contributions.

Noor E, Haraldsdóttir HS, Milo R, Fleming RM.

PLoS Comput Biol. 2013;9(7):e1003098. doi: 10.1371/journal.pcbi.1003098. Epub 2013 Jul 11.


Quantifying translational coupling in E. coli synthetic operons using RBS modulation and fluorescent reporters.

Levin-Karp A, Barenholz U, Bareia T, Dayagi M, Zelcbuch L, Antonovsky N, Noor E, Milo R.

ACS Synth Biol. 2013 Jun 21;2(6):327-36. doi: 10.1021/sb400002n. Epub 2013 Apr 16.


Glycolytic strategy as a tradeoff between energy yield and protein cost.

Flamholz A, Noor E, Bar-Even A, Liebermeister W, Milo R.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):10039-44. doi: 10.1073/pnas.1215283110. Epub 2013 Apr 29.


Spanning high-dimensional expression space using ribosome-binding site combinatorics.

Zelcbuch L, Antonovsky N, Bar-Even A, Levin-Karp A, Barenholz U, Dayagi M, Liebermeister W, Flamholz A, Noor E, Amram S, Brandis A, Bareia T, Yofe I, Jubran H, Milo R.

Nucleic Acids Res. 2013 May;41(9):e98. doi: 10.1093/nar/gkt151. Epub 2013 Mar 6.

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