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Results: 1 to 20 of 82

1.

Allosteric modulation of nicotinic acetylcholine receptors.

Chatzidaki A, Millar NS.

Biochem Pharmacol. 2015 Jul 28. pii: S0006-2952(15)00417-7. doi: 10.1016/j.bcp.2015.07.028. [Epub ahead of print] Review.

PMID:
26231943
2.

The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors.

Chatzidaki A, D'Oyley JM, Gill-Thind JK, Sheppard TD, Millar NS.

Neuropharmacology. 2015 May 19;97:75-85. doi: 10.1016/j.neuropharm.2015.05.006. [Epub ahead of print]

3.

Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons.

Chatzidaki A, Fouillet A, Li J, Dage J, Millar NS, Sher E, Ursu D.

PLoS One. 2015 Apr 23;10(4):e0125116. doi: 10.1371/journal.pone.0125116. eCollection 2015.

4.

Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.

Gill-Thind JK, Dhankher P, D'Oyley JM, Sheppard TD, Millar NS.

J Biol Chem. 2015 Feb 6;290(6):3552-62. doi: 10.1074/jbc.M114.619221. Epub 2014 Dec 16.

5.

Activation of human 5-hydroxytryptamine type 3 receptors via an allosteric transmembrane site.

Lansdell SJ, Sathyaprakash C, Doward A, Millar NS.

Mol Pharmacol. 2015 Jan;87(1):87-95. doi: 10.1124/mol.114.094540. Epub 2014 Oct 22.

PMID:
25338672
6.

Tracking the molecular evolution of calcium permeability in a nicotinic acetylcholine receptor.

Lipovsek M, Fierro A, Pérez EG, Boffi JC, Millar NS, Fuchs PA, Katz E, Elgoyhen AB.

Mol Biol Evol. 2014 Dec;31(12):3250-65. doi: 10.1093/molbev/msu258. Epub 2014 Sep 5.

7.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

8.

Contrasting properties of α7-selective orthosteric and allosteric agonists examined on native nicotinic acetylcholine receptors.

Gill JK, Chatzidaki A, Ursu D, Sher E, Millar NS.

PLoS One. 2013;8(1):e55047. doi: 10.1371/journal.pone.0055047. Epub 2013 Jan 29.

9.

A nicotinic acetylcholine receptor transmembrane point mutation (G275E) associated with resistance to spinosad in Frankliniella occidentalis.

Puinean AM, Lansdell SJ, Collins T, Bielza P, Millar NS.

J Neurochem. 2013 Mar;124(5):590-601. doi: 10.1111/jnc.12029. Epub 2013 Jan 13.

10.

Activation of α7 nicotinic receptors by orthosteric and allosteric agonists: influence on single-channel kinetics and conductance.

Pałczyńska MM, Jindrichova M, Gibb AJ, Millar NS.

Mol Pharmacol. 2012 Nov;82(5):910-7. doi: 10.1124/mol.112.080259. Epub 2012 Aug 8.

11.

The Drosophila nicotinic acetylcholine receptor subunits Dα5 and Dα7 form functional homomeric and heteromeric ion channels.

Lansdell SJ, Collins T, Goodchild J, Millar NS.

BMC Neurosci. 2012 Jun 22;13:73. doi: 10.1186/1471-2202-13-73.

12.

A novel mode-of-action mediated by the fetal muscle nicotinic acetylcholine receptor resulting in developmental toxicity in rats.

Rasoulpour RJ, Ellis-Hutchings RG, Terry C, Millar NS, Zablotny CL, Gibb A, Marshall V, Collins T, Carney EW, Billington R.

Toxicol Sci. 2012 Jun;127(2):522-34. doi: 10.1093/toxsci/kfs118. Epub 2012 Mar 29.

13.

Changes in temperature have opposing effects on current amplitude in α7 and α4β2 nicotinic acetylcholine receptors.

Jindrichova M, Lansdell SJ, Millar NS.

PLoS One. 2012;7(2):e32073. doi: 10.1371/journal.pone.0032073. Epub 2012 Feb 16.

14.

A series of α7 nicotinic acetylcholine receptor allosteric modulators with close chemical similarity but diverse pharmacological properties.

Gill JK, Dhankher P, Sheppard TD, Sher E, Millar NS.

Mol Pharmacol. 2012 May;81(5):710-8. doi: 10.1124/mol.111.076026. Epub 2012 Feb 10.

15.

Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization.

Collins T, Young GT, Millar NS.

Neuropharmacology. 2011 Dec;61(8):1306-13. doi: 10.1016/j.neuropharm.2011.07.035. Epub 2011 Jul 30.

16.

Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.

Gill JK, Savolainen M, Young GT, Zwart R, Sher E, Millar NS.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5867-72. doi: 10.1073/pnas.1017975108. Epub 2011 Mar 21.

17.

Characterisation of insect nicotinic acetylcholine receptors by heterologous expression.

Millar NS, Lansdell SJ.

Adv Exp Med Biol. 2010;683:65-73. Review.

PMID:
20737789
18.

Amplification of a cytochrome P450 gene is associated with resistance to neonicotinoid insecticides in the aphid Myzus persicae.

Puinean AM, Foster SP, Oliphant L, Denholm I, Field LM, Millar NS, Williamson MS, Bass C.

PLoS Genet. 2010 Jun 24;6(6):e1000999. doi: 10.1371/journal.pgen.1000999.

19.

Nicotinic acetylcholine receptor transmembrane mutations convert ivermectin from a positive to a negative allosteric modulator.

Collins T, Millar NS.

Mol Pharmacol. 2010 Aug;78(2):198-204. doi: 10.1124/mol.110.064295. Epub 2010 May 12.

20.

Native subunit composition of two insect nicotinic receptor subtypes with differing affinities for the insecticide imidacloprid.

Li J, Shao Y, Ding Z, Bao H, Liu Z, Han Z, Millar NS.

Insect Biochem Mol Biol. 2010 Jan;40(1):17-22. doi: 10.1016/j.ibmb.2009.12.003. Epub 2009 Dec 30.

PMID:
20005950
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