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Mode & mechanism of low intensity pulsed ultrasound (LIPUS) in fracture repair.

Harrison A, Lin S, Pounder N, Mikuni-Takagaki Y.

Ultrasonics. 2016 Apr 9;70:45-52. doi: 10.1016/j.ultras.2016.03.016. [Epub ahead of print] Review.


Low-intensity pulsed ultrasound induces apoptosis in osteoclasts: Fish scales are a suitable model for the analysis of bone metabolism by ultrasound.

Suzuki N, Hanmoto T, Yano S, Furusawa Y, Ikegame M, Tabuchi Y, Kondo T, Kitamura K, Endo M, Yamamoto T, Sekiguchi T, Urata M, Mikuni-Takagaki Y, Hattori A.

Comp Biochem Physiol A Mol Integr Physiol. 2016 May;195:26-31. doi: 10.1016/j.cbpa.2016.01.022. Epub 2016 Feb 2.


Alendronate does not prevent long bone fragility in an inactive rat model.

Naruse K, Uchida K, Suto M, Miyagawa K, Kawata A, Urabe K, Takaso M, Itoman M, Mikuni-Takagaki Y.

J Bone Miner Metab. 2015 Oct 16. [Epub ahead of print]


A not-so-systematic review.

Heeckt P, Goost H, Lin SS, McKinley TO, Mehta S, Mikuni-Takagaki Y.

Can J Surg. 2014 Oct;57(5):E150-1. No abstract available.


Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp mice.

Miyagawa K, Yamazaki M, Kawai M, Nishino J, Koshimizu T, Ohata Y, Tachikawa K, Mikuni-Takagaki Y, Kogo M, Ozono K, Michigami T.

PLoS One. 2014 Apr 7;9(4):e93840. doi: 10.1371/journal.pone.0093840. eCollection 2014.


Zebrafish scales respond differently to in vitro dynamic and static acceleration: analysis of interaction between osteoblasts and osteoclasts.

Kitamura K, Takahira K, Inari M, Satoh Y, Hayakawa K, Tabuchi Y, Ogai K, Nishiuchi T, Kondo T, Mikuni-Takagaki Y, Chen W, Hattori A, Suzuki N.

Comp Biochem Physiol A Mol Integr Physiol. 2013 Sep;166(1):74-80. doi: 10.1016/j.cbpa.2013.04.023. Epub 2013 Apr 28.


Multimolecular salivary mucin complex is altered in saliva of cigarette smokers: detection of disulfide bridges by Raman spectroscopy.

Taniguchi M, Iizuka J, Murata Y, Ito Y, Iwamiya M, Mori H, Hirata Y, Mukai Y, Mikuni-Takagaki Y.

Biomed Res Int. 2013;2013:168765. doi: 10.1155/2013/168765. Epub 2012 Dec 26.


Static and dynamic hypergravity responses of osteoblasts and osteoclasts in medaka scales.

Yano S, Kitamura K, Satoh Y, Nakano M, Hattori A, Sekiguchi T, Ikegame M, Nakashima H, Omori K, Hayakawa K, Chiba A, Sasayama Y, Ejiri S, Mikuni-Takagaki Y, Mishima H, Funahashi H, Sakamoto T, Suzuki N.

Zoolog Sci. 2013 Mar;30(3):217-23. doi: 10.2108/zsj.30.217.


Disruption of NF-κB1 prevents bone loss caused by mechanical unloading.

Nakamura H, Aoki K, Masuda W, Alles N, Nagano K, Fukushima H, Osawa K, Yasuda H, Nakamura I, Mikuni-Takagaki Y, Ohya K, Maki K, Jimi E.

J Bone Miner Res. 2013 Jun;28(6):1457-67. doi: 10.1002/jbmr.1866.


Differential age-related bone architecture changes between female and male STR/Ort mice.

Uchida K, Urabe K, Naruse K, Kozai Y, Onuma K, Mikuni-Takagaki Y, Kashima I, Ueno M, Sakai R, Itoman M, Takaso M.

Exp Anim. 2012;61(1):59-66.


Mechanotransduction activates α₅β₁ integrin and PI3K/Akt signaling pathways in mandibular osteoblasts.

Watabe H, Furuhama T, Tani-Ishii N, Mikuni-Takagaki Y.

Exp Cell Res. 2011 Nov 1;317(18):2642-9. doi: 10.1016/j.yexcr.2011.07.015. Epub 2011 Jul 29.


A novel underuse model shows that inactivity but not ovariectomy determines the deteriorated material properties and geometry of cortical bone in the tibia of adult rats.

Miyagawa K, Kozai Y, Ito Y, Furuhama T, Naruse K, Nonaka K, Nagai Y, Yamato H, Kashima I, Ohya K, Aoki K, Mikuni-Takagaki Y.

J Bone Miner Metab. 2011 Jul;29(4):422-36. doi: 10.1007/s00774-010-0241-9. Epub 2010 Dec 3.


Repeated freeze-thaw cycles reduce the survival rate of osteocytes in bone-tendon constructs without affecting the mechanical properties of tendons.

Suto K, Urabe K, Naruse K, Uchida K, Matsuura T, Mikuni-Takagaki Y, Suto M, Nemoto N, Kamiya K, Itoman M.

Cell Tissue Bank. 2012 Mar;13(1):71-80. doi: 10.1007/s10561-010-9234-0. Epub 2010 Nov 30.


Prolonged endochondral bone healing in senescence is shortened by low-intensity pulsed ultrasound in a manner dependent on COX-2.

Naruse K, Sekiya H, Harada Y, Iwabuchi S, Kozai Y, Kawamata R, Kashima I, Uchida K, Urabe K, Seto K, Itoman M, Mikuni-Takagaki Y.

Ultrasound Med Biol. 2010 Jul;36(7):1098-108. doi: 10.1016/j.ultrasmedbio.2010.04.011.


Osteoarthritic changes of the patellofemoral joint in STR/OrtCrlj mice are the earliest detectable changes and may be caused by internal tibial torsion.

Naruse K, Urabe K, Jiang SX, Uchida K, Kozai Y, Minehara H, Mikuni-Takagaki Y, Kashima I, Itoman M.

Connect Tissue Res. 2009;50(4):243-55. doi: 10.1080/03008200902836065.


Prior treatment with vitamin K(2) significantly improves the efficacy of risedronate.

Matsumoto Y, Mikuni-Takagaki Y, Kozai Y, Miyagawa K, Naruse K, Wakao H, Kawamata R, Kashima I, Sakurai T.

Osteoporos Int. 2009 Nov;20(11):1863-72. doi: 10.1007/s00198-009-0888-z. Epub 2009 Mar 12.


Therapeutic ultrasound induces periosteal ossification without apparent changes in cartilage.

Naruse K, Mikuni-Takagaki Y, Urabe K, Uchida K, Itoman M.

Connect Tissue Res. 2009;50(1):55-63. doi: 10.1080/03008200802419855.


Low-intensity pulsed ultrasound activates the phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional cultures: a basic science study.

Takeuchi R, Ryo A, Komitsu N, Mikuni-Takagaki Y, Fukui A, Takagi Y, Shiraishi T, Morishita S, Yamazaki Y, Kumagai K, Aoki I, Saito T.

Arthritis Res Ther. 2008;10(4):R77. doi: 10.1186/ar2451. Epub 2008 Jul 11.

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