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Year Number of Results
1947 1
1972 1
1977 1
1981 1
1989 1
1990 1
1991 2
1992 6
1993 4
1994 6
1995 3
1996 6
1997 1
1998 5
1999 6
2000 19
2001 6
2002 18
2003 12
2004 12
2005 18
2006 25
2007 20
2008 30
2009 28
2010 36
2011 40
2012 47
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2016 36
2017 36
2018 29
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2023 24
2024 11

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729 results

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Page 1
Bardoxolone methyl: drug development for diabetic kidney disease.
Kanda H, Yamawaki K. Kanda H, et al. Clin Exp Nephrol. 2020 Oct;24(10):857-864. doi: 10.1007/s10157-020-01917-5. Epub 2020 Jun 27. Clin Exp Nephrol. 2020. PMID: 32594372 Free PMC article. Review.
Bardoxolone methyl activates the Keap1/Nrf2 system that plays an important role in defense responses against oxidative stress. Importantly, bardoxolone methyl has demonstrated increases in estimated glomerular filtration rate (eGFR) in patients with diabetic kidney …
Bardoxolone methyl activates the Keap1/Nrf2 system that plays an important role in defense responses against oxidative stress. Import …
Bardoxolone-the Phoenix?
Toto RD. Toto RD. J Am Soc Nephrol. 2018 Feb;29(2):360-361. doi: 10.1681/ASN.2017121317. Epub 2018 Jan 25. J Am Soc Nephrol. 2018. PMID: 29371416 Free PMC article. No abstract available.
Solvent-Directed Assembly of a Pyridinium-Tailored Methyl Oleanolate Amphiphile: Stepwise Growth of Microrods and Nanofibers.
Gao Y, Hao J, Wu J, Zhang X, Hu J, Ju Y. Gao Y, et al. Langmuir. 2016 Feb 23;32(7):1685-92. doi: 10.1021/acs.langmuir.5b04398. Epub 2016 Feb 9. Langmuir. 2016. PMID: 26829548
Although a few architectures have been fabricated by the self-assembly of natural triterpenoids, the precise control of shape and size is rarely studied. Herein, a methyl oleanolate-bearing amphiphile, 1-[2-(methyl oleanolate)-2-oxoethyl]pyridinium bro …
Although a few architectures have been fabricated by the self-assembly of natural triterpenoids, the precise control of shape and size is ra …
Oleanolic acid.
Pollier J, Goossens A. Pollier J, et al. Phytochemistry. 2012 May;77:10-5. doi: 10.1016/j.phytochem.2011.12.022. Epub 2012 Feb 28. Phytochemistry. 2012. PMID: 22377690 Review.
Oleanolic acid (3beta-hydroxyolean-12-en-28-oic acid) is a pentacyclic triterpenoid compound with a widespread occurrence throughout the plant kingdom. ...In this review, the recent progress in understanding the oleanolic acid biosynthesis and its pharmacology are d …
Oleanolic acid (3beta-hydroxyolean-12-en-28-oic acid) is a pentacyclic triterpenoid compound with a widespread occurrence throughout …
Biotransformation of oleanolic and maslinic methyl esters by Rhizomucor miehei CECT 2749.
Martinez A, Perojil A, Rivas F, Parra A, Garcia-Granados A, Fernandez-Vivas A. Martinez A, et al. Phytochemistry. 2015 Sep;117:500-508. doi: 10.1016/j.phytochem.2015.07.020. Epub 2015 Jul 30. Phytochemistry. 2015. PMID: 26232553
The pentacyclic triterpenoids methyl oleanolate, methyl maslinate, methyl 3beta-hydroxyolean-9(11),12-dien-28-oate, and methyl 2alpha,3beta-dihydroxy-12beta,13beta-epoxyolean-28-oate were biotransformed by Rhizomucor miehei CECT 2749. Microbial …
The pentacyclic triterpenoids methyl oleanolate, methyl maslinate, methyl 3beta-hydroxyolean-9(11),12-dien-28-oa …
[Challenges in kidney disease: therapeutic potential of bardoxolone methyl].
Yamawaki K. Yamawaki K. Nihon Yakurigaku Zasshi. 2022;157(4):261-264. doi: 10.1254/fpj.22007. Nihon Yakurigaku Zasshi. 2022. PMID: 35781457 Review. Japanese.
Oxidative stress and inflammation are thought to be related to the progression of kidney diseases, and the Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) system is known to a key factor for anti-oxidative, anti-inflammatory properties …
Oxidative stress and inflammation are thought to be related to the progression of kidney diseases, and the Kelch-like ECH-associated protein …
A preliminary evaluation of bardoxolone methyl for the treatment of diabetic nephropathy.
Thomas M. Thomas M. Expert Opin Drug Metab Toxicol. 2012 Aug;8(8):1015-22. doi: 10.1517/17425255.2012.697152. Epub 2012 Jun 30. Expert Opin Drug Metab Toxicol. 2012. PMID: 22747345 Review.
INTRODUCTION: The coordinated activation of Nrf-2-dependent signaling pathway is currently being investigated in a range of chronic diseases. Bardoxolone methyl is a potent, orally bioavailable Nrf-2 agonist. In a recent 52-week study, treatment with bardoxolone methyl …
INTRODUCTION: The coordinated activation of Nrf-2-dependent signaling pathway is currently being investigated in a range of chronic diseases …
Prospective safety study of bardoxolone methyl in patients with type 2 diabetes mellitus, end-stage renal disease and peritoneal dialysis.
Warnock DG, Hebbar S, Bargman J, Burkart J, Davies S, Finkelstein FO, Mehrotra R, Ronco C, Teitelbaum I, Urakpo K, Chertow GM. Warnock DG, et al. Contrib Nephrol. 2012;178:157-163. doi: 10.1159/000337837. Epub 2012 May 25. Contrib Nephrol. 2012. PMID: 22652731 Review.
The decline in residual renal function has been associated with an increased mortality for patients in this population. Bardoxolone methyl is a synthetic triterpenoid. To date, the effects of bardoxolone methyl on kidney function in humans have been studied in patie …
The decline in residual renal function has been associated with an increased mortality for patients in this population. Bardoxolone methy …
729 results