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Ah Receptor Activation by Dioxin Disrupts Activin, BMP, and WNT Signals during the Early Differentiation of Mouse Embryonic Stem Cells and Inhibits Cardiomyocyte Functions.

Wang Q, Kurita H, Carreira V, Ko CI, Fan Y, Zhang X, Biesiada J, Medvedovic M, Puga A.

Toxicol Sci. 2015 Nov 15. pii: kfv246. [Epub ahead of print]


Disruption of Ah Receptor Signaling during Mouse Development Leads to Abnormal Cardiac Structure and Function in the Adult.

Carreira VS, Fan Y, Kurita H, Wang Q, Ko CI, Naticchioni M, Jiang M, Koch S, Zhang X, Biesiada J, Medvedovic M, Xia Y, Rubinstein J, Puga A.

PLoS One. 2015 Nov 10;10(11):e0142440. doi: 10.1371/journal.pone.0142440. eCollection 2015.


Bisphenol A disrupts HNF4α-regulated gene networks linking to prostate preneoplasia and immune disruption in Noble rats.

Lam HM, Ho SM, Chen J, Medvedovic M, Tam NN.

Endocrinology. 2015 Oct 23:en20151363. [Epub ahead of print]


Fibrocytes Regulate Wilms Tumor 1-Positive Cell Accumulation in Severe Fibrotic Lung Disease.

Sontake V, Shanmukhappa SK, DiPasquale BA, Reddy GB, Medvedovic M, Hardie WD, White ES, Madala SK.

J Immunol. 2015 Oct 15;195(8):3978-91. doi: 10.4049/jimmunol.1500963. Epub 2015 Sep 14.


Exposure of Human Prostaspheres to Bisphenol A Epigenetically Regulates SNORD Family Noncoding RNAs via Histone Modification.

Ho SM, Cheong A, Lam HM, Hu WY, Shi GB, Zhu X, Chen J, Zhang X, Medvedovic M, Leung YK, Prins GS.

Endocrinology. 2015 Nov;156(11):3984-95. doi: 10.1210/en.2015-1067. Epub 2015 Aug 6.


Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes.

Carreira VS, Fan Y, Wang Q, Zhang X, Kurita H, Ko CI, Naticchioni M, Jiang M, Koch S, Medvedovic M, Xia Y, Rubinstein J, Puga A.

Toxicol Sci. 2015 Oct;147(2):425-35. doi: 10.1093/toxsci/kfv138. Epub 2015 Jul 2.


Identification of secretaglobin Scgb2a1 as a target for developmental reprogramming by BPA in the rat prostate.

Wong RL, Wang Q, Treviño LS, Bosland MC, Chen J, Medvedovic M, Prins GS, Kannan K, Ho SM, Walker CL.

Epigenetics. 2015;10(2):127-34. doi: 10.1080/15592294.2015.1009768.


Sex- and tissue-specific methylome changes in brains of mice perinatally exposed to lead.

Sánchez-Martín FJ, Lindquist DM, Landero-Figueroa J, Zhang X, Chen J, Cecil KM, Medvedovic M, Puga A.

Neurotoxicology. 2015 Jan;46:92-100. doi: 10.1016/j.neuro.2014.12.004. Epub 2014 Dec 18.


Stratified randomization controls better for batch effects in 450K methylation analysis: a cautionary tale.

Buhule OD, Minster RL, Hawley NL, Medvedovic M, Sun G, Viali S, Deka R, McGarvey ST, Weeks DE.

Front Genet. 2014 Oct 13;5:354. doi: 10.3389/fgene.2014.00354. eCollection 2014.


Targeting GPR30 with G-1: a new therapeutic target for castration-resistant prostate cancer.

Lam HM, Ouyang B, Chen J, Ying J, Wang J, Wu CL, Jia L, Medvedovic M, Vessella RL, Ho SM.

Endocr Relat Cancer. 2014;21(6):903-14. doi: 10.1530/ERC-14-0402. Epub 2014 Oct 6.


SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene.

Cheng XH, Black M, Ustiyan V, Le T, Fulford L, Sridharan A, Medvedovic M, Kalinichenko VV, Whitsett JA, Kalin TV.

PLoS Genet. 2014 Sep 25;10(9):e1004656. doi: 10.1371/journal.pgen.1004656. eCollection 2014 Sep.


SERPINB3/B4 contributes to early inflammation and barrier dysfunction in an experimental murine model of atopic dermatitis.

Sivaprasad U, Kinker KG, Ericksen MB, Lindsey M, Gibson AM, Bass SA, Hershey NS, Deng J, Medvedovic M, Khurana Hershey GK.

J Invest Dermatol. 2015 Jan;135(1):160-9. doi: 10.1038/jid.2014.353. Epub 2014 Aug 11.


Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) analysis uncovers broad changes in chromatin structure resulting from hexavalent chromium exposure.

Ovesen JL, Fan Y, Zhang X, Chen J, Medvedovic M, Xia Y, Puga A.

PLoS One. 2014 May 16;9(5):e97849. doi: 10.1371/journal.pone.0097849. eCollection 2014.


Expression of signaling components in embryonic eyelid epithelium.

Meng Q, Jin C, Chen Y, Chen J, Medvedovic M, Xia Y.

PLoS One. 2014 Feb 3;9(2):e87038. doi: 10.1371/journal.pone.0087038. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e106783.


Dual targeting of MEK and PI3K pathways attenuates established and progressive pulmonary fibrosis.

Madala SK, Edukulla R, Phatak M, Schmidt S, Davidson C, Acciani TH, Korfhagen TR, Medvedovic M, Lecras TD, Wagner K, Hardie WD.

PLoS One. 2014 Jan 27;9(1):e86536. doi: 10.1371/journal.pone.0086536. eCollection 2014.


Overexpression of dimethylarginine dimethylaminohydrolase 1 attenuates airway inflammation in a mouse model of asthma.

Kinker KG, Gibson AM, Bass SA, Day BP, Deng J, Medvedovic M, Figueroa JA, Hershey GK, Chen W.

PLoS One. 2014 Jan 10;9(1):e85148. doi: 10.1371/journal.pone.0085148. eCollection 2014.


Long-term exposure to low-concentrations of Cr(VI) induce DNA damage and disrupt the transcriptional response to benzo[a]pyrene.

Ovesen JL, Fan Y, Chen J, Medvedovic M, Xia Y, Puga A.

Toxicology. 2014 Feb 28;316:14-24. doi: 10.1016/j.tox.2013.12.001. Epub 2013 Dec 26.


Expressomal approach for comprehensive analysis and visualization of ligand sensitivities of xenoestrogen responsive genes.

Shioda T, Rosenthal NF, Coser KR, Suto M, Phatak M, Medvedovic M, Carey VJ, Isselbacher KJ.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16508-13. doi: 10.1073/pnas.1315929110. Epub 2013 Sep 23.


Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiation alters expression of homeobox transcription factors that control cardiomyogenesis.

Wang Q, Chen J, Ko CI, Fan Y, Carreira V, Chen Y, Xia Y, Medvedovic M, Puga A.

Environ Health Perspect. 2013 Nov-Dec;121(11-12):1334-43. doi: 10.1289/ehp.1307297. Epub 2013 Sep 20.


Genome-wide signatures of transcription factor activity: connecting transcription factors, disease, and small molecules.

Chen J, Hu Z, Phatak M, Reichard J, Freudenberg JM, Sivaganesan S, Medvedovic M.

PLoS Comput Biol. 2013;9(9):e1003198. doi: 10.1371/journal.pcbi.1003198. Epub 2013 Sep 5.

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