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The progress in understanding and treatment of diabetic retinopathy.

Stitt AW, Curtis TM, Chen M, Medina RJ, McKay GJ, Jenkins A, Gardiner TA, Lyons TJ, Hammes HP, Simó R, Lois N.

Prog Retin Eye Res. 2015 Aug 18. pii: S1350-9462(15)00066-X. doi: 10.1016/j.preteyeres.2015.08.001. [Epub ahead of print]


Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications.

Rajasekar P, O'Neill CL, Eeles L, Stitt AW, Medina RJ.

J Diabetes Res. 2015;2015:436879. doi: 10.1155/2015/436879. Epub 2015 May 28. Review.


Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells.

Prasain N, Lee MR, Vemula S, Meador JL, Yoshimoto M, Ferkowicz MJ, Fett A, Gupta M, Rapp BM, Saadatzadeh MR, Ginsberg M, Elemento O, Lee Y, Voytik-Harbin SL, Chung HM, Hong KS, Reid E, O'Neill CL, Medina RJ, Stitt AW, Murphy MP, Rafii S, Broxmeyer HE, Yoder MC.

Nat Biotechnol. 2014 Nov;32(11):1151-7. doi: 10.1038/nbt.3048. Epub 2014 Oct 12.


Endothelial progenitor cells in diabetic retinopathy.

Lois N, McCarter RV, O'Neill C, Medina RJ, Stitt AW.

Front Endocrinol (Lausanne). 2014 Apr 9;5:44. doi: 10.3389/fendo.2014.00044. eCollection 2014. Review.


The role of immune-related myeloid cells in angiogenesis.

Chambers SE, O'Neill CL, O'Doherty TM, Medina RJ, Stitt AW.

Immunobiology. 2013 Nov;218(11):1370-5. doi: 10.1016/j.imbio.2013.06.010. Epub 2013 Jul 8. Review.


Ex vivo expansion of human outgrowth endothelial cells leads to IL-8-mediated replicative senescence and impaired vasoreparative function.

Medina RJ, O'Neill CL, O'Doherty TM, Chambers SE, Guduric-Fuchs J, Neisen J, Waugh DJ, Simpson DA, Stitt AW.

Stem Cells. 2013 Aug;31(8):1657-68. doi: 10.1002/stem.1414.


Advances in our understanding of diabetic retinopathy.

Stitt AW, Lois N, Medina RJ, Adamson P, Curtis TM.

Clin Sci (Lond). 2013 Mar 13;125(1):1-17. doi: 10.1042/CS20120588. Review.


Therapeutic revascularisation of ischaemic tissue: the opportunities and challenges for therapy using vascular stem/progenitor cells.

O'Neill CL, O'Doherty MT, Wilson SE, Rana AA, Hirst CE, Stitt AW, Medina RJ.

Stem Cell Res Ther. 2012 Aug 16;3(4):31. doi: 10.1186/scrt122. Review.


Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types.

Guduric-Fuchs J, O'Connor A, Camp B, O'Neill CL, Medina RJ, Simpson DA.

BMC Genomics. 2012 Aug 1;13:357. doi: 10.1186/1471-2164-13-357.


Vasculogenic and osteogenesis-enhancing potential of human umbilical cord blood endothelial colony-forming cells.

Liu Y, Teoh SH, Chong MS, Lee ES, Mattar CN, Randhawa NK, Zhang ZY, Medina RJ, Kamm RD, Fisk NM, Choolani M, Chan JK.

Stem Cells. 2012 Sep;30(9):1911-24. doi: 10.1002/stem.1164.


Endothelial progenitors as tools to study vascular disease.

Medina RJ, O'Neill CL, O'Doherty TM, Wilson SE, Stitt AW.

Stem Cells Int. 2012;2012:346735. doi: 10.1155/2012/346735. Epub 2012 Mar 15.


Deep sequencing reveals predominant expression of miR-21 amongst the small non-coding RNAs in retinal microvascular endothelial cells.

Guduric-Fuchs J, O'Connor A, Cullen A, Harwood L, Medina RJ, O'Neill CL, Stitt AW, Curtis TM, Simpson DA.

J Cell Biochem. 2012 Jun;113(6):2098-111. doi: 10.1002/jcb.24084.


Eyes open to stem cells: safety trial may pave the way for cell therapy to treat retinal disease in patients.

Medina RJ, Archer DB, Stitt AW.

Stem Cell Res Ther. 2011 Dec 7;2(6):47. doi: 10.1186/scrt88.


Myeloid angiogenic cells act as alternative M2 macrophages and modulate angiogenesis through interleukin-8.

Medina RJ, O'Neill CL, O'Doherty TM, Knott H, Guduric-Fuchs J, Gardiner TA, Stitt AW.

Mol Med. 2011 Sep-Oct;17(9-10):1045-55. doi: 10.2119/molmed.2011.00129. Epub 2011 Jun 9.


Vascular stem cells and ischaemic retinopathies.

Stitt AW, O'Neill CL, O'Doherty MT, Archer DB, Gardiner TA, Medina RJ.

Prog Retin Eye Res. 2011 May;30(3):149-66. doi: 10.1016/j.preteyeres.2011.02.001. Epub 2011 Feb 23. Review.


Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15.

Yamamoto K, Sakaguchi M, Medina RJ, Niida A, Sakaguchi Y, Miyazaki M, Kataoka K, Huh NH.

Biochem Biophys Res Commun. 2010 Sep 10;400(1):175-80. doi: 10.1016/j.bbrc.2010.08.039. Epub 2010 Aug 13.


Differential modulation of angiogenesis by erythropoiesis-stimulating agents in a mouse model of ischaemic retinopathy.

McVicar CM, Colhoun LM, Abrahams JL, Kitson CL, Hamilton R, Medina RJ, Durga D, Gardiner TA, Rudd PM, Stitt AW.

PLoS One. 2010 Jul 29;5(7):e11870. doi: 10.1371/journal.pone.0011870.


Outgrowth endothelial cells: characterization and their potential for reversing ischemic retinopathy.

Medina RJ, O'Neill CL, Humphreys MW, Gardiner TA, Stitt AW.

Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5906-13. doi: 10.1167/iovs.09-4951. Epub 2010 Jun 16.


Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities.

Medina RJ, O'Neill CL, Sweeney M, Guduric-Fuchs J, Gardiner TA, Simpson DA, Stitt AW.

BMC Med Genomics. 2010 May 13;3:18. doi: 10.1186/1755-8794-3-18.

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