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Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor.

Burns MR, Graminski GF, Weeks RS, Chen Y, O'Brien TG.

J Med Chem. 2009 Apr 9;52(7):1983-93. doi: 10.1021/jm801580w.


Structural correlation between lipophilicity and lipopolysaccharide-sequestering activity in spermine-sulfonamide analogs.

Burns MR, Jenkins SA, Vermeulen NM, Balakrishna R, Nguyen TB, Kimbrell MR, David SA.

Bioorg Med Chem Lett. 2006 Dec 15;16(24):6209-12. Epub 2006 Sep 28.

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