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Items: 1 to 20 of 80

1.

The kinetic characterization and X-ray structure of a putative benzoylformate decarboxylase from M. smegmatis highlights the difficulties in the functional annotation of ThDP-dependent enzymes.

Andrews FH, Horton JD, Shin D, Yoon HJ, Logsdon MG, Malik AM, Rogers MP, Kneen MM, Suh SW, McLeish MJ.

Biochim Biophys Acta. 2015 Aug;1854(8):1001-9. doi: 10.1016/j.bbapap.2015.04.027. Epub 2015 Apr 30.

PMID:
25936776
2.

Extended reaction scope of thiamine diphosphate dependent cyclohexane-1,2-dione hydrolase: from C-C bond cleavage to C-C bond ligation.

Loschonsky S, Wacker T, Waltzer S, Giovannini PP, McLeish MJ, Andrade SL, Müller M.

Angew Chem Int Ed Engl. 2014 Dec 22;53(52):14402-6. doi: 10.1002/anie.201408287. Epub 2014 Nov 7.

PMID:
25382418
3.

Perturbation of the monomer-monomer interfaces of the benzoylformate decarboxylase tetramer.

Andrews FH, Rogers MP, Paul LN, McLeish MJ.

Biochemistry. 2014 Jul 15;53(27):4358-67. doi: 10.1021/bi500081r. Epub 2014 Jul 3.

4.

Identification of charge transfer transitions related to thiamin-bound intermediates on enzymes provides a plethora of signatures useful in mechanistic studies.

Patel H, Nemeria NS, Andrews FH, McLeish MJ, Jordan F.

Biochemistry. 2014 Apr 8;53(13):2145-52. doi: 10.1021/bi4015743. Epub 2014 Mar 26.

5.

Kinetic and pH studies on human phenylethanolamine N-methyltransferase.

Wu Q, McLeish MJ.

Arch Biochem Biophys. 2013 Nov 1;539(1):1-8. doi: 10.1016/j.abb.2013.08.019. Epub 2013 Sep 7.

6.

Delayed colonisation of Acacia by thrips and the timing of host-conservatism and behavioural specialisation.

McLeish MJ, Miller JT, Mound LA.

BMC Evol Biol. 2013 Sep 9;13:188. doi: 10.1186/1471-2148-13-188.

7.

Using site-saturation mutagenesis to explore mechanism and substrate specificity in thiamin diphosphate-dependent enzymes.

Andrews FH, McLeish MJ.

FEBS J. 2013 Dec;280(24):6395-411. doi: 10.1111/febs.12459. Epub 2013 Aug 23. Review.

8.

A bulky hydrophobic residue is not required to maintain the V-conformation of enzyme-bound thiamin diphosphate.

Andrews FH, Tom AR, Gunderman PR, Novak WR, McLeish MJ.

Biochemistry. 2013 May 7;52(18):3028-30. doi: 10.1021/bi400368j. Epub 2013 Apr 23.

PMID:
23607689
9.

Host-plant species conservatism and ecology of a parasitoid fig wasp genus (Chalcidoidea; Sycoryctinae; Arachonia).

McLeish MJ, Beukman G, van Noort S, Wossler TC.

PLoS One. 2012;7(9):e44804. doi: 10.1371/journal.pone.0044804. Epub 2012 Sep 10.

10.

Substrate specificity in thiamin diphosphate-dependent decarboxylases.

Andrews FH, McLeish MJ.

Bioorg Chem. 2012 Aug;43:26-36. doi: 10.1016/j.bioorg.2011.12.001. Epub 2011 Dec 30. Review.

PMID:
22245019
11.

Codivergence and multiple host species use by fig wasp populations of the Ficus pollination mutualism.

McLeish MJ, van Noort S.

BMC Evol Biol. 2012 Jan 3;12:1. doi: 10.1186/1471-2148-12-1.

12.

Characterization of a thiamin diphosphate-dependent phenylpyruvate decarboxylase from Saccharomyces cerevisiae.

Kneen MM, Stan R, Yep A, Tyler RP, Saehuan C, McLeish MJ.

FEBS J. 2011 Jun;278(11):1842-53. doi: 10.1111/j.1742-4658.2011.08103.x. Epub 2011 Apr 18.

13.

Structural relationship between the active sites of β-lactam-recognizing and amidase signature enzymes: convergent evolution?

Pratt RF, McLeish MJ.

Biochemistry. 2010 Nov 16;49(45):9688-97. doi: 10.1021/bi1012222. Epub 2010 Oct 26.

PMID:
20977193
14.

Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors.

Drinkwater N, Vu H, Lovell KM, Criscione KR, Collins BM, Prisinzano TE, Poulsen SA, McLeish MJ, Grunewald GL, Martin JL.

Biochem J. 2010 Oct 1;431(1):51-61. doi: 10.1042/BJ20100651.

PMID:
20642456
15.

African parasitoid fig wasp diversification is a function of Ficus species ranges.

McLeish MJ, van Noort S, Tolley KA.

Mol Phylogenet Evol. 2010 Oct;57(1):122-34. doi: 10.1016/j.ympev.2010.05.025. Epub 2010 Jun 8.

PMID:
20554053
16.

Parasitoid fig-wasp evolutionary diversification and variation in ecological opportunity.

McLeish MJ, van Noort S, Tolley KA.

Mol Ecol. 2010 Apr;19(7):1483-96. doi: 10.1111/j.1365-294X.2010.04583.x.

PMID:
20456233
17.

Active-site engineering of benzaldehyde lyase shows that a point mutation can confer both new reactivity and susceptibility to mechanism-based inhibition.

Brandt GS, Kneen MM, Petsko GA, Ringe D, McLeish MJ.

J Am Chem Soc. 2010 Jan 20;132(2):438-9. doi: 10.1021/ja907064w.

PMID:
20030408
18.

The reaction mechanism of phenylethanolamine N-methyltransferase: a density functional theory study.

Georgieva P, Wu Q, McLeish MJ, Himo F.

Biochim Biophys Acta. 2009 Dec;1794(12):1831-7. doi: 10.1016/j.bbapap.2009.08.022. Epub 2009 Sep 3.

19.

Engineering the substrate binding site of benzoylformate decarboxylase.

Yep A, McLeish MJ.

Biochemistry. 2009 Sep 8;48(35):8387-95. doi: 10.1021/bi9008402.

PMID:
19621900
20.

Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity.

Drinkwater N, Gee CL, Puri M, Criscione KR, McLeish MJ, Grunewald GL, Martin JL.

Biochem J. 2009 Aug 27;422(3):463-71. doi: 10.1042/BJ20090702.

PMID:
19570037
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