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Page 1
First-line nivolumab plus ipilimumab versus chemotherapy for the treatment of unresectable malignant pleural mesothelioma: patient-reported outcomes in CheckMate 743.
Scherpereel A, Antonia S, Bautista Y, Grossi F, Kowalski D, Zalcman G, Nowak AK, Fujimoto N, Peters S, Tsao AS, Mansfield AS, Popat S, Sun X, Lawrance R, Zhang X, Daumont MJ, Bennett B, McKenna M, Baas P. Scherpereel A, et al. Lung Cancer. 2022 May;167:8-16. doi: 10.1016/j.lungcan.2022.03.012. Epub 2022 Mar 21. Lung Cancer. 2022. PMID: 35367910 Free article. Clinical Trial.
Changes in disease-related symptom burden and health-related quality of life (HRQoL) were evaluated descriptively using the Lung Cancer Symptom Scale (LCSS)-Mesothelioma (Meso) average symptom burden index (ASBI), LCSS-Meso 3-item global index (3-IGI), 3-level EuroQol 5-dimension …
Changes in disease-related symptom burden and health-related quality of life (HRQoL) were evaluated descriptively using the Lung Cancer Symp …
Measurement, modeling and QALYs.
Langley PC, McKenna SP. Langley PC, et al. F1000Res. 2020 Aug 26;9:1048. doi: 10.12688/f1000research.25039.1. eCollection 2020. F1000Res. 2020. PMID: 33093950 Free PMC article.
Those advocating QALY-based lifetime modeled claims fail to appreciate the limitations placed on these constructs by the axioms of fundamental measurement. Utility scales, such as those created by the EQ-5D-3L instrument, are nothing more than multidimensional, ordinal sca …
Those advocating QALY-based lifetime modeled claims fail to appreciate the limitations placed on these constructs by the axioms of fundament …
Fundamental Measurement: The Need Fulfilment Quality of Life (N-QOL) Measure.
Langley PC, McKenna SP. Langley PC, et al. Innov Pharm. 2021 May 11;12(2):10.24926/iip.v12i2.3798. doi: 10.24926/iip.v12i2.3798. eCollection 2021. Innov Pharm. 2021. PMID: 34345508 Free PMC article.
Multiattribute utility scores (e.g. those generated by the EQ-5D-5L) fail to meet this standard. The multiattribute instruments produce ordinal scores that lack a true zero and they generate negative values. ...
Multiattribute utility scores (e.g. those generated by the EQ-5D-5L) fail to meet this standard. The multiattribute instruments produ …
Health-related quality of life in survivors of septic shock: 6-month follow-up from the ADRENAL trial.
Hammond NE, Finfer SR, Li Q, Taylor C, Cohen J, Arabi Y, Bellomo R, Billot L, Harward M, Joyce C, McArthur C, Myburgh J, Perner A, Rajbhandari D, Rhodes A, Thompson K, Webb S, Venkatesh B; ADRENAL Trial Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Hammond NE, et al. Intensive Care Med. 2020 Sep;46(9):1696-1706. doi: 10.1007/s00134-020-06169-1. Epub 2020 Jul 16. Intensive Care Med. 2020. PMID: 32676679
Of these 2151 patients (85.3%-1080 hydrocortisone and 1071 placebo) completed 6-month follow-up. Overall, at 6 months the mean EQ-5D-5L visual analogue scale (VAS) was 70.8, mean utility score 59.4. ...Bacteraemia was not associated with worse HRQoL in any domains of the E …
Of these 2151 patients (85.3%-1080 hydrocortisone and 1071 placebo) completed 6-month follow-up. Overall, at 6 months the mean EQ-5D- …
The relationship between oral-health-related quality of life and general health in an elderly population: A cross-sectional study.
da Mata C, Allen PF, McKenna GJ, Hayes M, Kashan A. da Mata C, et al. Gerodontology. 2019 Mar;36(1):71-77. doi: 10.1111/ger.12384. Epub 2018 Dec 7. Gerodontology. 2019. PMID: 30536976
All patients completed the Oral Health Impact Profile (OHIP-14) and EuroQol-5D (EQ-5D) questionnaires. All patients provided a comprehensive overview of their general medical status. ...Pearson's correlation analysis showed a negative association between OHIP-14 and …
All patients completed the Oral Health Impact Profile (OHIP-14) and EuroQol-5D (EQ-5D) questionnaires. All patients provided a …
Computerized adaptive testing in back pain: validation of the CAT-5D-QOL.
Kopec JA, Badii M, McKenna M, Lima VD, Sayre EC, Dvorak M. Kopec JA, et al. Spine (Phila Pa 1976). 2008 May 20;33(12):1384-90. doi: 10.1097/BRS.0b013e3181732a3b. Spine (Phila Pa 1976). 2008. PMID: 18496353
RESULTS: A total of 215 patients completed the questionnaire and 84 completed a retest. On average, patients answered 5.2 items per CAT-5D-QOL scale. Reliability ranged from 0.83 (FEEL) to 0.92 (PAIN) and was 0.92 for the MODI, RMDQ, and Physical Component Summary (PCS-36) …
RESULTS: A total of 215 patients completed the questionnaire and 84 completed a retest. On average, patients answered 5.2 items per CAT-5 …
Assessment of the utility of the National Health Service England Low Back and Radicular Pain Pathway: analysis of patient reported outcomes.
McKeag P, Eames N, Murphy L, McKenna R, Simpson E, Graham G. McKeag P, et al. Br J Pain. 2020 Feb;14(1):42-46. doi: 10.1177/2049463719846913. Epub 2019 May 13. Br J Pain. 2020. PMID: 32110397 Free PMC article.
Mean Oswestry Low Back Pain Disability Questionnaire score before nerve root injection was 58.4% and 49.7% following nerve root injection (p = 0.024). Mean Euroqol EQ-5D-5L Health Index was 0.2 before nerve root injection and 0.4 afterwards (p < 0.001). ...
Mean Oswestry Low Back Pain Disability Questionnaire score before nerve root injection was 58.4% and 49.7% following nerve root injection (p …
Interpreting scores on multiple sclerosis-specific patient reported outcome measures (the PRIMUS and U-FIS).
Twiss J, Doward LC, McKenna SP, Eckert B. Twiss J, et al. Health Qual Life Outcomes. 2010 Oct 11;8:117. doi: 10.1186/1477-7525-8-117. Health Qual Life Outcomes. 2010. PMID: 20937112 Free PMC article. Clinical Trial.
Anchor-based estimates were based on published RD values for the EQ-5D and were assessed for those improving and deteriorating separately. ...
Anchor-based estimates were based on published RD values for the EQ-5D and were assessed for those improving and deteriorating separa …
Development and validation of a preference based measure derived from the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) for use in cost utility analyses.
McKenna SP, Ratcliffe J, Meads DM, Brazier JE. McKenna SP, et al. Health Qual Life Outcomes. 2008 Aug 21;6:65. doi: 10.1186/1477-7525-6-65. Health Qual Life Outcomes. 2008. PMID: 18718016 Free PMC article.
The CAMPHOR utility score appears better able to distinguish between WHO functional classes (II and III) than the EQ-5D and SF-6D. CONCLUSION: The tariff derived in this study can be used to classify an individual into a health state based on their responses to the CAMPHOR …
The CAMPHOR utility score appears better able to distinguish between WHO functional classes (II and III) than the EQ-5D and SF-6D. CO …
12 results