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Fibroblast growth factors, old kids on the new block.

Li X, Wang C, Xiao J, McKeehan WL, Wang F.

Semin Cell Dev Biol. 2016 May;53:155-67. doi: 10.1016/j.semcdb.2015.12.014. Epub 2016 Jan 6. Review.


Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed.

Li W, Zou J, Yue F, Song K, Chen Q, McKeehan WL, Wang F, Xu G, Huang H, Yi J, Liu L.

Aging Cell. 2016 Apr;15(2):370-9. doi: 10.1111/acel.12441. Epub 2016 Jan 10.


MAP1S Protein Regulates the Phagocytosis of Bacteria and Toll-like Receptor (TLR) Signaling.

Shi M, Zhang Y, Liu L, Zhang T, Han F, Cleveland J, Wang F, McKeehan WL, Li Y, Zhang D.

J Biol Chem. 2016 Jan 15;291(3):1243-50. doi: 10.1074/jbc.M115.687376. Epub 2015 Nov 12.


Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin.

Yue F, Li W, Zou J, Chen Q, Xu G, Huang H, Xu Z, Zhang S, Gallinari P, Wang F, McKeehan WL, Liu L.

Aging (Albany NY). 2015 Oct;7(10):839-53.


Overexpression of FGF9 in prostate epithelial cells augments reactive stroma formation and promotes prostate cancer progression.

Huang Y, Jin C, Hamana T, Liu J, Wang C, An L, McKeehan WL, Wang F.

Int J Biol Sci. 2015 Jun 11;11(8):948-60. doi: 10.7150/ijbs.12468. eCollection 2015.


Hyperactivated FRS2α-mediated signaling in prostate cancer cells promotes tumor angiogenesis and predicts poor clinical outcome of patients.

Liu J, You P, Chen G, Fu X, Zeng X, Wang C, Huang Y, An L, Wan X, Navone N, Wu CL, McKeehan WL, Zhang Z, Zhong W, Wang F.

Oncogene. 2016 Apr 7;35(14):1750-9. doi: 10.1038/onc.2015.239. Epub 2015 Jun 22.


Prostate Sphere-forming Stem Cells Are Derived from the P63-expressing Basal Compartment.

Huang Y, Hamana T, Liu J, Wang C, An L, You P, Chang JY, Xu J, McKeehan WL, Wang F.

J Biol Chem. 2015 Jul 17;290(29):17745-52. doi: 10.1074/jbc.M115.661033. Epub 2015 Jun 1.


Type 2 Fibroblast Growth Factor Receptor Signaling Preserves Stemness and Prevents Differentiation of Prostate Stem Cells from the Basal Compartment.

Huang Y, Hamana T, Liu J, Wang C, An L, You P, Chang JY, Xu J, Jin C, Zhang Z, McKeehan WL, Wang F.

J Biol Chem. 2015 Jul 17;290(29):17753-61. doi: 10.1074/jbc.M115.661066. Epub 2015 Jun 1.


Hepatocyte FRS2α is essential for the endocrine fibroblast growth factor to limit the amplitude of bile acid production induced by prandial activity.

Wang C, Yang C, Chang JY, You P, Li Y, Jin C, Luo Y, Li X, McKeehan WL, Wang F.

Curr Mol Med. 2014;14(6):703-11.


Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer.

Fuentes-Mattei E, Velazquez-Torres G, Phan L, Zhang F, Chou PC, Shin JH, Choi HH, Chen JS, Zhao R, Chen J, Gully C, Carlock C, Qi Y, Zhang Y, Wu Y, Esteva FJ, Luo Y, McKeehan WL, Ensor J, Hortobagyi GN, Pusztai L, Fraser Symmans W, Lee MH, Yeung SC.

J Natl Cancer Inst. 2014 Jun 23;106(7). pii: dju158. doi: 10.1093/jnci/dju158. Print 2014 Jul.


Restoration of fibroblast growth factor receptor 2IIIb enhances the chemosensitivity of human prostate cancer cells.

Shoji K, Teishima J, Hayashi T, Ohara S, Mckeehan WL, Matsubara A.

Oncol Rep. 2014 Jul;32(1):65-70. doi: 10.3892/or.2014.3200. Epub 2014 May 20.


Stressed Liver and Muscle Call on Adipocytes with FGF21.

Luo Y, McKeehan WL.

Front Endocrinol (Lausanne). 2013 Dec 18;4:194. doi: 10.3389/fendo.2013.00194. Review.


Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations.

Luo Y, Yang C, Ye M, Jin C, Abbruzzese JL, Lee MH, Yeung SC, McKeehan WL.

Cancer Metab. 2013 Nov 25;1(1):21. doi: 10.1186/2049-3002-1-21.


FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway.

Jung D, York JP, Wang L, Yang C, Zhang A, Francis HL, Webb P, McKeehan WL, Alpini G, Lesage GD, Moore DD, Xia X.

Pflugers Arch. 2014 May;466(5):1011-9. doi: 10.1007/s00424-013-1364-3. Epub 2013 Sep 26.


Targeting fibroblast growth factor pathways in prostate cancer.

Corn PG, Wang F, McKeehan WL, Navone N.

Clin Cancer Res. 2013 Nov 1;19(21):5856-66. doi: 10.1158/1078-0432.CCR-13-1550. Epub 2013 Sep 19. Review.


Fibroblast growth factor signaling is essential for self-renewal of dental epithelial stem cells.

Chang JY, Wang C, Liu J, Huang Y, Jin C, Yang C, Hai B, Liu F, D'Souza RN, McKeehan WL, Wang F.

J Biol Chem. 2013 Oct 4;288(40):28952-61. doi: 10.1074/jbc.M113.506873. Epub 2013 Aug 26.


Self-renewal and multilineage differentiation of mouse dental epithelial stem cells.

Chang JY, Wang C, Jin C, Yang C, Huang Y, Liu J, McKeehan WL, D'Souza RN, Wang F.

Stem Cell Res. 2013 Nov;11(3):990-1002. doi: 10.1016/j.scr.2013.06.008. Epub 2013 Jul 1.


Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis.

Wang C, Chang JY, Yang C, Huang Y, Liu J, You P, McKeehan WL, Wang F, Li X.

J Biol Chem. 2013 Jul 26;288(30):22174-83. doi: 10.1074/jbc.M113.463620. Epub 2013 Jun 10.


Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress.

Yang C, Lu W, Lin T, You P, Ye M, Huang Y, Jiang X, Wang C, Wang F, Lee MH, Yeung SC, Johnson RL, Wei C, Tsai RY, Frazier ML, McKeehan WL, Luo Y.

BMC Gastroenterol. 2013 Apr 17;13:67. doi: 10.1186/1471-230X-13-67.


Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress.

Yang C, Wang C, Ye M, Jin C, He W, Wang F, McKeehan WL, Luo Y.

Nutr Metab (Lond). 2012 Oct 30;9(1):94. doi: 10.1186/1743-7075-9-94.

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