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Items: 1 to 20 of 142


Formaldehyde Stress Responses in Bacterial Pathogens.

Chen NH, Djoko KY, Veyrier FJ, McEwan AG.

Front Microbiol. 2016 Mar 3;7:257. doi: 10.3389/fmicb.2016.00257. eCollection 2016. Review.


Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages.

Kapetanovic R, Bokil NJ, Achard ME, Ong CY, Peters KM, Stocks CJ, Phan MD, Monteleone M, Schroder K, Irvine KM, Saunders BM, Walker MJ, Stacey KJ, McEwan AG, Schembri MA, Sweet MJ.

FASEB J. 2016 Feb 2. pii: fj.201500061. [Epub ahead of print]


Defence against methylglyoxal in Group A Streptococcus: a role for Glyoxylase I in bacterial virulence and survival in neutrophils?

Zhang MM, Ong CL, Walker MJ, McEwan AG.

Pathog Dis. 2016 Mar;74(2). pii: ftv122. doi: 10.1093/femspd/ftv122. Epub 2015 Dec 23.


Maturation of molybdoenzymes and its influence on the pathogenesis of non-typeable Haemophilus influenzae.

Dhouib R, Pg Othman DS, Essilfie AT, Hansbro PM, Hanson JO, McEwan AG, Kappler U.

Front Microbiol. 2015 Nov 5;6:1219. doi: 10.3389/fmicb.2015.01219. eCollection 2015.


Copper(II)-Bis(Thiosemicarbazonato) Complexes as Antibacterial Agents: Insights into Their Mode of Action and Potential as Therapeutics.

Djoko KY, Goytia MM, Donnelly PS, Schembri MA, Shafer WM, McEwan AG.

Antimicrob Agents Chemother. 2015 Oct;59(10):6444-53. doi: 10.1128/AAC.01289-15. Epub 2015 Aug 3.


A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae.

Atack JM, Srikhanta YN, Fox KL, Jurcisek JA, Brockman KL, Clark TA, Boitano M, Power PM, Jen FE, McEwan AG, Grimmond SM, Smith AL, Barenkamp SJ, Korlach J, Bakaletz LO, Jennings MP.

Nat Commun. 2015 Jul 28;6:7828. doi: 10.1038/ncomms8828.


The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens.

Djoko KY, Ong CL, Walker MJ, McEwan AG.

J Biol Chem. 2015 Jul 31;290(31):18954-61. doi: 10.1074/jbc.R115.647099. Epub 2015 Jun 8. Review.


A genetic screen reveals a periplasmic copper chaperone required for nitrite reductase activity in pathogenic Neisseria.

Jen FE, Djoko KY, Bent SJ, Day CJ, McEwan AG, Jennings MP.

FASEB J. 2015 Sep;29(9):3828-38. doi: 10.1096/fj.15-270751. Epub 2015 Jun 1.


Zinc disrupts central carbon metabolism and capsule biosynthesis in Streptococcus pyogenes.

Ong CL, Walker MJ, McEwan AG.

Sci Rep. 2015 Jun 1;5:10799. doi: 10.1038/srep10799.


Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence.

Turner AG, Ong CL, Gillen CM, Davies MR, West NP, McEwan AG, Walker MJ.

MBio. 2015 Mar 24;6(2). pii: e00278-15. doi: 10.1128/mBio.00278-15.


Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach.

Bajaj M, Mamidyala SK, Zuegg J, Begg SL, Ween MP, Luo Z, Huang JX, McEwan AG, Kobe B, Paton JC, McDevitt CA, Cooper MA.

ACS Chem Biol. 2015 Jun 19;10(6):1511-20. doi: 10.1021/cb501032x. Epub 2015 Mar 30.


Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae.

Begg SL, Eijkelkamp BA, Luo Z, Couñago RM, Morey JR, Maher MJ, Ong CL, McEwan AG, Kobe B, O'Mara ML, Paton JC, McDevitt CA.

Nat Commun. 2015 Mar 3;6:6418. doi: 10.1038/ncomms7418.


Electrochemically mediated enantioselective reduction of chiral sulfoxides.

Chen KI, Challinor VL, Kielmann L, Sharpe PC, De Voss JJ, Kappler U, McEwan AG, Bernhardt PV.

J Biol Inorg Chem. 2015 Mar;20(2):395-402. doi: 10.1007/s00775-014-1215-5. Epub 2014 Nov 20.


Inhibition of respiratory complex I by copper(ii)-bis(thiosemicarbazonato) complexes.

Djoko KY, Donnelly PS, McEwan AG.

Metallomics. 2014 Dec;6(12):2250-9. doi: 10.1039/c4mt00226a. Epub 2014 Nov 4.


A role for lactate dehydrogenases in the survival of Neisseria gonorrhoeae in human polymorphonuclear leukocytes and cervical epithelial cells.

Atack JM, Ibranovic I, Ong CL, Djoko KY, Chen NH, Vanden Hoven R, Jennings MP, Edwards JL, McEwan AG.

J Infect Dis. 2014 Oct 15;210(8):1311-8. doi: 10.1093/infdis/jiu230. Epub 2014 Apr 15.


Metabolic versatility in Haemophilus influenzae: a metabolomic and genomic analysis.

Othman DS, Schirra H, McEwan AG, Kappler U.

Front Microbiol. 2014 Mar 4;5:69. doi: 10.3389/fmicb.2014.00069. eCollection 2014.


Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniae.

Eijkelkamp BA, Morey JR, Ween MP, Ong CL, McEwan AG, Paton JC, McDevitt CA.

PLoS One. 2014 Feb 18;9(2):e89427. doi: 10.1371/journal.pone.0089427. eCollection 2014.


An antimicrobial role for zinc in innate immune defense against group A streptococcus.

Ong CL, Gillen CM, Barnett TC, Walker MJ, McEwan AG.

J Infect Dis. 2014 May 15;209(10):1500-8. doi: 10.1093/infdis/jiu053. Epub 2014 Jan 20.


Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action.

Djoko KY, Paterson BM, Donnelly PS, McEwan AG.

Metallomics. 2014 Apr;6(4):854-63. doi: 10.1039/c3mt00348e.


Imperfect coordination chemistry facilitates metal ion release in the Psa permease.

Couñago RM, Ween MP, Begg SL, Bajaj M, Zuegg J, O'Mara ML, Cooper MA, McEwan AG, Paton JC, Kobe B, McDevitt CA.

Nat Chem Biol. 2014 Jan;10(1):35-41. doi: 10.1038/nchembio.1382. Epub 2013 Nov 10.

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