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Items: 1 to 20 of 331


Creating shape templates for patient specific biventricular modeling in congenital heart disease.

Gilbert K, Farrar G, Cowan BR, Suinesiaputra A, Occleshaw C, Pontre B, Perry J, Hegde S, Marsden A, Omens J, McCulloch A, Young AA.

Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:679-82. doi: 10.1109/EMBC.2015.7318453.


3D cardiac μtissues within a microfluidic device with real-time contractile stress readout.

Aung A, Bhullar IS, Theprungsirikul J, Davey SK, Lim HL, Chiu YJ, Ma X, Dewan S, Lo YH, McCulloch A, Varghese S.

Lab Chip. 2016 Jan 7;16(1):153-62. doi: 10.1039/c5lc00820d. Epub 2015 Nov 20.


Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction.

Sanna MG, Vincent KP, Repetto E, Nguyen N, Brown SJ, Abgaryan L, Riley SW, Leaf NB, Cahalan SM, Kiosses WB, Kohno Y, Brown JH, McCulloch AD, Rosen H, Gonzalez-Cabrera PJ.

Mol Pharmacol. 2016 Jan;89(1):176-86. doi: 10.1124/mol.115.100222. Epub 2015 Oct 22.


Bridging scales through multiscale modeling: a case study on protein kinase A.

Boras BW, Hirakis SP, Votapka LW, Malmstrom RD, Amaro RE, McCulloch AD.

Front Physiol. 2015 Sep 9;6:250. doi: 10.3389/fphys.2015.00250. eCollection 2015. Review.


Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation.

Cheng Y, Rao V, Tu AY, Lindert S, Wang D, Oxenford L, McCulloch AD, McCammon JA, Regnier M.

J Biol Chem. 2015 Nov 13;290(46):27749-66. doi: 10.1074/jbc.M115.683045. Epub 2015 Sep 21.


High-order finite element methods for cardiac monodomain simulations.

Vincent KP, Gonzales MJ, Gillette AK, Villongco CT, Pezzuto S, Omens JH, Holst MJ, McCulloch AD.

Front Physiol. 2015 Aug 5;6:217. doi: 10.3389/fphys.2015.00217. eCollection 2015.


Buccal swabbing as a noninvasive method to determine bacterial, archaeal, and eukaryotic microbial community structures in the rumen.

Kittelmann S, Kirk MR, Jonker A, McCulloch A, Janssen PH.

Appl Environ Microbiol. 2015 Nov;81(21):7470-83. doi: 10.1128/AEM.02385-15. Epub 2015 Aug 14.


Intramyocardial injection of hydrogel with high interstitial spread does not impact action potential propagation.

Suarez SL, Rane AA, Muñoz A, Wright AT, Zhang SX, Braden RL, Almutairi A, McCulloch AD, Christman KL.

Acta Biomater. 2015 Oct 15;26:13-22. doi: 10.1016/j.actbio.2015.08.004. Epub 2015 Aug 8.


Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes.

Morotti S, McCulloch AD, Bers DM, Edwards AG, Grandi E.

J Mol Cell Cardiol. 2015 Aug 1. pii: S0022-2828(15)30031-6. doi: 10.1016/j.yjmcc.2015.07.030. [Epub ahead of print]


Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice.

Stobdan T, Zhou D, Ao-Ieong E, Ortiz D, Ronen R, Hartley I, Gan Z, McCulloch AD, Bafna V, Cabrales P, Haddad GG.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10425-30. doi: 10.1073/pnas.1507486112. Epub 2015 Aug 3.


HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes.

Guimarães-Camboa N, Stowe J, Aneas I, Sakabe N, Cattaneo P, Henderson L, Kilberg MS, Johnson RS, Chen J, McCulloch AD, Nobrega MA, Evans SM, Zambon AC.

Dev Cell. 2015 Jun 8;33(5):507-21. doi: 10.1016/j.devcel.2015.04.021. Epub 2015 May 28.


A Protocol to Collect Specific Mouse Skeletal Muscles for Metabolomics Studies.

Gan Z, Fu Z, Stowe JC, Powell FL, McCulloch AD.

Methods Mol Biol. 2015 May 24. [Epub ahead of print]


Multi-bio and multi-scale systems biology.

Henney A, Hunter P, McCulloch A, Noble D.

Prog Biophys Mol Biol. 2015 Jan;117(1):1-3. doi: 10.1016/j.pbiomolbio.2015.03.001. No abstract available.


Left Ventricular Diastolic and Systolic Material Property Estimation from Image Data: LV Mechanics Challenge.

Krishnamurthy A, Villongco C, Beck A, Omens J, McCulloch A.

Stat Atlases Comput Models Heart. 2015 Jan;8896:63-73.


Structural contributions to fibrillatory rotors in a patient-derived computational model of the atria.

Gonzales MJ, Vincent KP, Rappel WJ, Narayan SM, McCulloch AD.

Europace. 2014 Nov;16 Suppl 4:iv3-iv10. doi: 10.1093/europace/euu251.


Computational studies of the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics.

Cheng Y, Lindert S, Kekenes-Huskey P, Rao VS, Solaro RJ, Rosevear PR, Amaro R, McCulloch AD, McCammon JA, Regnier M.

Biophys J. 2014 Oct 7;107(7):1675-85. doi: 10.1016/j.bpj.2014.08.008.


Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing.

Pfeiffer ER, Wright AT, Edwards AG, Stowe JC, McNall K, Tan J, Niesman I, Patel HH, Roth DM, Omens JH, McCulloch AD.

J Mol Cell Cardiol. 2014 Nov;76:265-74. doi: 10.1016/j.yjmcc.2014.09.014. Epub 2014 Sep 26.


Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle.

Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD.

Circ Arrhythm Electrophysiol. 2014 Dec;7(6):1205-13. doi: 10.1161/CIRCEP.113.001666. Epub 2014 Sep 18.


Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIα activation in response to cAMP binding.

Boras BW, Kornev A, Taylor SS, McCulloch AD.

J Biol Chem. 2014 Oct 24;289(43):30040-51. doi: 10.1074/jbc.M114.568907. Epub 2014 Sep 8.


PKA phosphorylation of cardiac troponin I modulates activation and relaxation kinetics of ventricular myofibrils.

Rao V, Cheng Y, Lindert S, Wang D, Oxenford L, McCulloch AD, McCammon JA, Regnier M.

Biophys J. 2014 Sep 2;107(5):1196-204. doi: 10.1016/j.bpj.2014.07.027.

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