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Results: 1 to 20 of 44

1.

Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy.

Mageed SN, Cunningham F, Hung AW, Silvestre HL, Wen S, Blundell TL, Abell C, McConkey GA.

Antimicrob Agents Chemother. 2014 Nov;58(11):6345-53. doi: 10.1128/AAC.02640-14. Epub 2014 Jul 21.

PMID:
25049241
[PubMed - in process]
2.

Toxoplasma gondii infection and behaviour - location, location, location?

McConkey GA, Martin HL, Bristow GC, Webster JP.

J Exp Biol. 2013 Jan 1;216(Pt 1):113-9. doi: 10.1242/jeb.074153. Review.

PMID:
23225873
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Toxoplasma gondii infection, from predation to schizophrenia: can animal behaviour help us understand human behaviour?

Webster JP, Kaushik M, Bristow GC, McConkey GA.

J Exp Biol. 2013 Jan 1;216(Pt 1):99-112. doi: 10.1242/jeb.074716.

PMID:
23225872
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases.

Bedingfield PT, Cowen D, Acklam P, Cunningham F, Parsons MR, McConkey GA, Fishwick CW, Johnson AP.

J Med Chem. 2012 Jun 28;55(12):5841-50. doi: 10.1021/jm300157n. Epub 2012 Jun 15.

PMID:
22621375
[PubMed - indexed for MEDLINE]
5.

The neurotropic parasite Toxoplasma gondii increases dopamine metabolism.

Prandovszky E, Gaskell E, Martin H, Dubey JP, Webster JP, McConkey GA.

PLoS One. 2011;6(9):e23866. doi: 10.1371/journal.pone.0023866. Epub 2011 Sep 21.

PMID:
21957440
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Gene function prediction using semantic similarity clustering and enrichment analysis in the malaria parasite Plasmodium falciparum.

Tedder PM, Bradford JR, Needham CJ, McConkey GA, Bulpitt AJ, Westhead DR.

Bioinformatics. 2010 Oct 1;26(19):2431-7. doi: 10.1093/bioinformatics/btq450. Epub 2010 Aug 6.

PMID:
20693320
[PubMed - indexed for MEDLINE]
Free Article
7.

MetNetMaker: a free and open-source tool for the creation of novel metabolic networks in SBML format.

Forth T, McConkey GA, Westhead DR.

Bioinformatics. 2010 Sep 15;26(18):2352-3. doi: 10.1093/bioinformatics/btq425. Epub 2010 Jul 29.

PMID:
20671147
[PubMed - indexed for MEDLINE]
Free Article
8.

Toxoplasma gondii-altered host behaviour: clues as to mechanism of action.

Webster JP, McConkey GA.

Folia Parasitol (Praha). 2010 Jun;57(2):95-104. Review.

PMID:
20608471
[PubMed - indexed for MEDLINE]
9.

PlasmoPredict: a gene function prediction website for Plasmodium falciparum.

Tedder PM, Bradford JR, McConkey GA, Bulpitt AJ, Westhead DR.

Trends Parasitol. 2010 Mar;26(3):107-10. doi: 10.1016/j.pt.2009.12.004. Epub 2010 Jan 19.

PMID:
20089451
[PubMed - indexed for MEDLINE]
10.

A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH.

Cowen D, Bedingfield P, McConkey GA, Fishwick CW, Johnson AP.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1284-7. doi: 10.1016/j.bmcl.2009.11.079. Epub 2009 Nov 27.

PMID:
20034791
[PubMed - indexed for MEDLINE]
11.

Alio intuitu: the automated reconstruction of the metabolic networks of parasites.

Whitaker JW, Westhead DR, McConkey GA.

Trends Parasitol. 2009 Sep;25(9):396-7. doi: 10.1016/j.pt.2009.06.001. Epub 2009 Aug 28. No abstract available.

PMID:
19717343
[PubMed - indexed for MEDLINE]
12.

Prediction of horizontal gene transfers in eukaryotes: approaches and challenges.

Whitaker JW, McConkey GA, Westhead DR.

Biochem Soc Trans. 2009 Aug;37(Pt 4):792-5. doi: 10.1042/BST0370792. Review. Erratum in: Biochem Soc Trans. 2009 Oct;37(Pt 5):1145.

PMID:
19614596
[PubMed - indexed for MEDLINE]
13.

The transferome of metabolic genes explored: analysis of the horizontal transfer of enzyme encoding genes in unicellular eukaryotes.

Whitaker JW, McConkey GA, Westhead DR.

Genome Biol. 2009;10(4):R36. doi: 10.1186/gb-2009-10-4-r36. Epub 2009 Apr 15.

PMID:
19368726
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.

Davies M, Heikkilä T, McConkey GA, Fishwick CW, Parsons MR, Johnson AP.

J Med Chem. 2009 May 14;52(9):2683-93. doi: 10.1021/jm800963t.

PMID:
19351152
[PubMed - indexed for MEDLINE]
15.

A unique dual activity amino acid hydroxylase in Toxoplasma gondii.

Gaskell EA, Smith JE, Pinney JW, Westhead DR, McConkey GA.

PLoS One. 2009;4(3):e4801. doi: 10.1371/journal.pone.0004801. Epub 2009 Mar 11.

PMID:
19277211
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

metaTIGER: a metabolic evolution resource.

Whitaker JW, Letunic I, McConkey GA, Westhead DR.

Nucleic Acids Res. 2009 Jan;37(Database issue):D531-8. doi: 10.1093/nar/gkn826. Epub 2008 Oct 25.

PMID:
18953037
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Metabolic reconstruction and analysis for parasite genomes.

Pinney JW, Papp B, Hyland C, Wambua L, Westhead DR, McConkey GA.

Trends Parasitol. 2007 Nov;23(11):548-54. Epub 2007 Oct 22. Review.

PMID:
17950669
[PubMed - indexed for MEDLINE]
18.

Nucleoside transport as a potential target for chemotherapy in malaria.

Baldwin SA, McConkey GA, Cass CE, Young JD.

Curr Pharm Des. 2007;13(6):569-80. Review.

PMID:
17346175
[PubMed - indexed for MEDLINE]
19.

Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.

Heikkilä T, Ramsey C, Davies M, Galtier C, Stead AM, Johnson AP, Fishwick CW, Boa AN, McConkey GA.

J Med Chem. 2007 Jan 25;50(2):186-91.

PMID:
17228860
[PubMed - indexed for MEDLINE]
20.

metaSHARK: a WWW platform for interactive exploration of metabolic networks.

Hyland C, Pinney JW, McConkey GA, Westhead DR.

Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W725-8.

PMID:
16845107
[PubMed - indexed for MEDLINE]
Free PMC Article

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