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Systems-level organization of yeast methylotrophic lifestyle.

Rußmayer H, Buchetics M, Gruber C, Valli M, Grillitsch K, Modarres G, Guerrasio R, Klavins K, Neubauer S, Drexler H, Steiger M, Troyer C, Al Chalabi A, Krebiehl G, Sonntag D, Zellnig G, Daum G, Graf AB, Altmann F, Koellensperger G, Hann S, Sauer M, Mattanovich D, Gasser B.

BMC Biol. 2015 Sep 23;13:80. doi: 10.1186/s12915-015-0186-5.


Metabolomics sampling of Pichia pastoris revisited: rapid filtration prevents metabolite loss during quenching.

Russmayer H, Troyer C, Neubauer S, Steiger MG, Gasser B, Hann S, Koellensperger G, Sauer M, Mattanovich D.

FEMS Yeast Res. 2015 Sep;15(6). pii: fov049. doi: 10.1093/femsyr/fov049. Epub 2015 Jun 19.


Multistep processing of the secretion leader of the extracellular protein Epx1 in Pichia pastoris and implications for protein localization.

Heiss S, Puxbaum V, Gruber C, Altmann F, Mattanovich D, Gasser B.

Microbiology. 2015 Jul;161(7):1356-68. doi: 10.1099/mic.0.000105. Epub 2015 May 1.


Enhanced glutathione production by evolutionary engineering of Saccharomyces cerevisiae strains.

Patzschke A, Steiger MG, Holz C, Lang C, Mattanovich D, Sauer M.

Biotechnol J. 2015 Apr 24. doi: 10.1002/biot.201400809. [Epub ahead of print]


Pichia pastoris regulates its gene-specific response to different carbon sources at the transcriptional, rather than the translational, level.

Prielhofer R, Cartwright SP, Graf AB, Valli M, Bill RM, Mattanovich D, Gasser B.

BMC Genomics. 2015 Mar 11;16:167. doi: 10.1186/s12864-015-1393-8.


Metabolomics integrated elementary flux mode analysis in large metabolic networks.

Gerstl MP, Ruckerbauer DE, Mattanovich D, Jungreuthmayer C, Zanghellini J.

Sci Rep. 2015 Mar 10;5:8930. doi: 10.1038/srep08930.


Quo vadis? The challenges of recombinant protein folding and secretion in Pichia pastoris.

Puxbaum V, Mattanovich D, Gasser B.

Appl Microbiol Biotechnol. 2015 Apr;99(7):2925-38. doi: 10.1007/s00253-015-6470-z. Epub 2015 Feb 27.


Organic acids from lignocellulose: Candida lignohabitans as a new microbial cell factory.

Bellasio M, Mattanovich D, Sauer M, Marx H.

J Ind Microbiol Biotechnol. 2015 May;42(5):681-91. doi: 10.1007/s10295-015-1590-0. Epub 2015 Feb 5.


Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.

Schosserer M, Minois N, Angerer TB, Amring M, Dellago H, Harreither E, Calle-Perez A, Pircher A, Gerstl MP, Pfeifenberger S, Brandl C, Sonntagbauer M, Kriegner A, Linder A, Weinhäusel A, Mohr T, Steiger M, Mattanovich D, Rinnerthaler M, Karl T, Sharma S, Entian KD, Kos M, Breitenbach M, Wilson IB, Polacek N, Grillari-Voglauer R, Breitenbach-Koller L, Grillari J.

Nat Commun. 2015 Jan 30;6:6158. doi: 10.1038/ncomms7158.


Pichia pastoris Aft1--a novel transcription factor, enhancing recombinant protein secretion.

Ruth C, Buchetics M, Vidimce V, Kotz D, Naschberger S, Mattanovich D, Pichler H, Gasser B.

Microb Cell Fact. 2014 Sep 3;13:120. doi: 10.1186/s12934-014-0120-5.


Identification of microRNAs specific for high producer CHO cell lines using steady-state cultivation.

Maccani A, Hackl M, Leitner C, Steinfellner W, Graf AB, Tatto NE, Karbiener M, Scheideler M, Grillari J, Mattanovich D, Kunert R, Borth N, Grabherr R, Ernst W.

Appl Microbiol Biotechnol. 2014 Sep;98(17):7535-48. doi: 10.1007/s00253-014-5911-4. Epub 2014 Jul 23.


Integrative omics analysis. A study based on Plasmodium falciparum mRNA and protein data.

Tomescu OA, Mattanovich D, Thallinger GG.

BMC Syst Biol. 2014;8 Suppl 2:S4. doi: 10.1186/1752-0509-8-S2-S4. Epub 2014 Mar 13.


Old obstacles and new horizons for microbial chemical production.

Porro D, Branduardi P, Sauer M, Mattanovich D.

Curr Opin Biotechnol. 2014 Dec;30:101-6. doi: 10.1016/j.copbio.2014.06.009. Epub 2014 Jul 5. Review.


Model based engineering of Pichia pastoris central metabolism enhances recombinant protein production.

Nocon J, Steiger MG, Pfeffer M, Sohn SB, Kim TY, Maurer M, Rußmayer H, Pflügl S, Ask M, Haberhauer-Troyer C, Ortmayr K, Hann S, Koellensperger G, Gasser B, Lee SY, Mattanovich D.

Metab Eng. 2014 Jul;24:129-38. doi: 10.1016/j.ymben.2014.05.011. Epub 2014 May 20.


Sample preparation workflow for the liquid chromatography tandem mass spectrometry based analysis of nicotinamide adenine dinucleotide phosphate cofactors in yeast.

Ortmayr K, Nocon J, Gasser B, Mattanovich D, Hann S, Koellensperger G.

J Sep Sci. 2014 Aug;37(16):2185-91. doi: 10.1002/jssc.201400290. Epub 2014 Jun 20.


Yeast biotechnology: teaching the old dog new tricks.

Mattanovich D, Sauer M, Gasser B.

Microb Cell Fact. 2014 Mar 6;13(1):34. doi: 10.1186/1475-2859-13-34.


Engineering of protein folding and secretion-strategies to overcome bottlenecks for efficient production of recombinant proteins.

Delic M, Göngrich R, Mattanovich D, Gasser B.

Antioxid Redox Signal. 2014 Jul 20;21(3):414-37. doi: 10.1089/ars.2014.5844. Epub 2014 Mar 24. Review.


Pichia pastoris secretes recombinant proteins less efficiently than Chinese hamster ovary cells but allows higher space-time yields for less complex proteins.

Maccani A, Landes N, Stadlmayr G, Maresch D, Leitner C, Maurer M, Gasser B, Ernst W, Kunert R, Mattanovich D.

Biotechnol J. 2014 Apr;9(4):526-37. doi: 10.1002/biot.201300305. Epub 2014 Jan 27.


Metabolic profiling of amino acids in cellular samples via zwitterionic sub-2 μm particle size HILIC-MS/MS and a uniformly 13C labeled internal standard.

Guerrasio R, Haberhauer-Troyer C, Mattanovich D, Koellensperger G, Hann S.

Anal Bioanal Chem. 2014 Jan;406(3):915-22. doi: 10.1007/s00216-013-7456-2. Epub 2013 Dec 12.

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