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Results: 1 to 20 of 43

1.

Inhibition of Cytochrome bc1 as a Strategy for Single-Dose, Multi-Stage Antimalarial Therapy.

Stickles AM, Ting LM, Morrisey JM, Li Y, Mather MW, Meermeier E, Pershing AM, Forquer IP, Miley GP, Pou S, Winter RW, Hinrichs DJ, Kelly JX, Kim K, Vaidya AB, Riscoe MK, Nilsen A.

Am J Trop Med Hyg. 2015 Apr 27. pii: 14-0553. [Epub ahead of print]

PMID:
25918204
2.

Genetic Investigation of Tricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle.

Ke H, Lewis IA, Morrisey JM, McLean KJ, Ganesan SM, Painter HJ, Mather MW, Jacobs-Lorena M, Llinás M, Vaidya AB.

Cell Rep. 2015 Apr 7;11(1):164-74. doi: 10.1016/j.celrep.2015.03.011. Epub 2015 Apr 2.

3.

The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages.

Ke H, Sigala PA, Miura K, Morrisey JM, Mather MW, Crowley JR, Henderson JP, Goldberg DE, Long CA, Vaidya AB.

J Biol Chem. 2014 Dec 12;289(50):34827-37. doi: 10.1074/jbc.M114.615831. Epub 2014 Oct 28.

PMID:
25352601
4.

Mutation of TNFRSF13B in a child with 22q11 deletion syndrome associated with granulomatous lymphoproliferation.

Mather MW, Hayhurst H, Bacon CM, Cole TS, Pan-Hammarström Q, Misbah S, Gennery AR.

J Allergy Clin Immunol. 2015 Feb;135(2):559-61. doi: 10.1016/j.jaci.2014.07.025. Epub 2014 Aug 28. No abstract available.

PMID:
25174870
5.

Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.

Nilsen A, Miley GP, Forquer IP, Mather MW, Katneni K, Li Y, Pou S, Pershing AM, Stickles AM, Ryan E, Kelly JX, Doggett JS, White KL, Hinrichs DJ, Winter RW, Charman SA, Zakharov LN, Bathurst I, Burrows JN, Vaidya AB, Riscoe MK.

J Med Chem. 2014 May 8;57(9):3818-34. doi: 10.1021/jm500147k. Epub 2014 Apr 18.

6.

Retraction: Branched tricarboxylic acid metabolism in Plasmodium falciparum.

Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M.

Nature. 2013 May 30;497(7451):652. doi: 10.1038/nature12164. Epub 2013 Apr 24. No abstract available.

7.

Quinolone-3-diarylethers: a new class of antimalarial drug.

Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE, Morrisey JM, Steuten J, Mutka T, Li Y, Wirjanata G, Ryan E, Duffy S, Kelly JX, Sebayang BF, Zeeman AM, Noviyanti R, Sinden RE, Kocken CH, Price RN, Avery VM, Angulo-Barturen I, Jiménez-Díaz MB, Ferrer S, Herreros E, Sanz LM, Gamo FJ, Bathurst I, Burrows JN, Siegl P, Guy RK, Winter RW, Vaidya AB, Charman SA, Kyle DE, Manetsch R, Riscoe MK.

Sci Transl Med. 2013 Mar 20;5(177):177ra37. doi: 10.1126/scitranslmed.3005029.

8.

Mitochondrial RNA polymerase is an essential enzyme in erythrocytic stages of Plasmodium falciparum.

Ke H, Morrisey JM, Ganesan SM, Mather MW, Vaidya AB.

Mol Biochem Parasitol. 2012 Sep;185(1):48-51. doi: 10.1016/j.molbiopara.2012.05.001. Epub 2012 May 26.

9.

Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control.

Coyne RS, Hannick L, Shanmugam D, Hostetler JB, Brami D, Joardar VS, Johnson J, Radune D, Singh I, Badger JH, Kumar U, Saier M, Wang Y, Cai H, Gu J, Mather MW, Vaidya AB, Wilkes DE, Rajagopalan V, Asai DJ, Pearson CG, Findly RC, Dickerson HW, Wu M, Martens C, Van de Peer Y, Roos DS, Cassidy-Hanley DM, Clark TG.

Genome Biol. 2011 Oct 17;12(10):R100. doi: 10.1186/gb-2011-12-10-r100.

10.

ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrial membranes and resistance to genetic disruption.

Balabaskaran Nina P, Morrisey JM, Ganesan SM, Ke H, Pershing AM, Mather MW, Vaidya AB.

J Biol Chem. 2011 Dec 2;286(48):41312-22. doi: 10.1074/jbc.M111.290973. Epub 2011 Oct 7.

11.

Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function.

Ke H, Morrisey JM, Ganesan SM, Painter HJ, Mather MW, Vaidya AB.

Eukaryot Cell. 2011 Aug;10(8):1053-61. doi: 10.1128/EC.05049-11. Epub 2011 Jun 17.

12.

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.

Ganesan SM, Morrisey JM, Ke H, Painter HJ, Laroiya K, Phillips MA, Rathod PK, Mather MW, Vaidya AB.

Mol Biochem Parasitol. 2011 May;177(1):29-34. doi: 10.1016/j.molbiopara.2011.01.004. Epub 2011 Jan 18.

13.

Branched tricarboxylic acid metabolism in Plasmodium falciparum.

Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M.

Nature. 2010 Aug 5;466(7307):774-8. doi: 10.1038/nature09301. Erratum in: Nature. 2011 Jan 20;469(7330):432. Retraction in: Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M. Nature. 2013 May 30;497(7451):652.

14.

Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies.

Mather MW, Morrisey JM, Vaidya AB.

Mol Biochem Parasitol. 2010 Dec;174(2):150-3. doi: 10.1016/j.molbiopara.2010.07.006. Epub 2010 Jul 30.

15.

Highly divergent mitochondrial ATP synthase complexes in Tetrahymena thermophila.

Balabaskaran Nina P, Dudkina NV, Kane LA, van Eyk JE, Boekema EJ, Mather MW, Vaidya AB.

PLoS Biol. 2010 Jul 13;8(7):e1000418. doi: 10.1371/journal.pbio.1000418.

16.

Mitochondrial evolution and functions in malaria parasites.

Vaidya AB, Mather MW.

Annu Rev Microbiol. 2009;63:249-67. doi: 10.1146/annurev.micro.091208.073424. Review.

PMID:
19575561
17.

Mitochondria in malaria and related parasites: ancient, diverse and streamlined.

Mather MW, Vaidya AB.

J Bioenerg Biomembr. 2008 Oct;40(5):425-33. doi: 10.1007/s10863-008-9176-4. Epub 2008 Sep 24. Review.

PMID:
18814021
18.

The validity of mitochondrial dehydrogenases as antimalarial drug targets.

Vaidya AB, Painter HJ, Morrisey JM, Mather MW.

Trends Parasitol. 2008 Jan;24(1):8-9. Epub 2007 Nov 26. No abstract available.

PMID:
18023619
19.

Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum.

Painter HJ, Morrisey JM, Mather MW, Vaidya AB.

Nature. 2007 Mar 1;446(7131):88-91.

PMID:
17330044
20.

Mitochondrial drug targets in apicomplexan parasites.

Mather MW, Henry KW, Vaidya AB.

Curr Drug Targets. 2007 Jan;8(1):49-60. Review.

PMID:
17266530
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