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Results: 1 to 20 of 39

1.

Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.

Nilsen A, Miley GP, Forquer IP, Mather MW, Katneni K, Li Y, Pou S, Pershing AM, Stickles AM, Ryan E, Kelly JX, Doggett JS, White KL, Hinrichs DJ, Winter RW, Charman SA, Zakharov LN, Bathurst I, Burrows JN, Vaidya AB, Riscoe MK.

J Med Chem. 2014 May 8;57(9):3818-34. doi: 10.1021/jm500147k. Epub 2014 Apr 18.

PMID:
24720377
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Retraction: Branched tricarboxylic acid metabolism in Plasmodium falciparum.

Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M.

Nature. 2013 May 30;497(7451):652. doi: 10.1038/nature12164. Epub 2013 Apr 24. No abstract available.

PMID:
23615611
[PubMed - indexed for MEDLINE]
3.

Quinolone-3-diarylethers: a new class of antimalarial drug.

Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE, Morrisey JM, Steuten J, Mutka T, Li Y, Wirjanata G, Ryan E, Duffy S, Kelly JX, Sebayang BF, Zeeman AM, Noviyanti R, Sinden RE, Kocken CH, Price RN, Avery VM, Angulo-Barturen I, Jiménez-Díaz MB, Ferrer S, Herreros E, Sanz LM, Gamo FJ, Bathurst I, Burrows JN, Siegl P, Guy RK, Winter RW, Vaidya AB, Charman SA, Kyle DE, Manetsch R, Riscoe MK.

Sci Transl Med. 2013 Mar 20;5(177):177ra37. doi: 10.1126/scitranslmed.3005029.

PMID:
23515079
[PubMed - indexed for MEDLINE]
Free Article
4.

Mitochondrial RNA polymerase is an essential enzyme in erythrocytic stages of Plasmodium falciparum.

Ke H, Morrisey JM, Ganesan SM, Mather MW, Vaidya AB.

Mol Biochem Parasitol. 2012 Sep;185(1):48-51. doi: 10.1016/j.molbiopara.2012.05.001. Epub 2012 May 26.

PMID:
22640832
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control.

Coyne RS, Hannick L, Shanmugam D, Hostetler JB, Brami D, Joardar VS, Johnson J, Radune D, Singh I, Badger JH, Kumar U, Saier M, Wang Y, Cai H, Gu J, Mather MW, Vaidya AB, Wilkes DE, Rajagopalan V, Asai DJ, Pearson CG, Findly RC, Dickerson HW, Wu M, Martens C, Van de Peer Y, Roos DS, Cassidy-Hanley DM, Clark TG.

Genome Biol. 2011 Oct 17;12(10):R100. doi: 10.1186/gb-2011-12-10-r100.

PMID:
22004680
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrial membranes and resistance to genetic disruption.

Balabaskaran Nina P, Morrisey JM, Ganesan SM, Ke H, Pershing AM, Mather MW, Vaidya AB.

J Biol Chem. 2011 Dec 2;286(48):41312-22. doi: 10.1074/jbc.M111.290973. Epub 2011 Oct 7.

PMID:
21984828
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function.

Ke H, Morrisey JM, Ganesan SM, Painter HJ, Mather MW, Vaidya AB.

Eukaryot Cell. 2011 Aug;10(8):1053-61. doi: 10.1128/EC.05049-11. Epub 2011 Jun 17.

PMID:
21685321
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.

Ganesan SM, Morrisey JM, Ke H, Painter HJ, Laroiya K, Phillips MA, Rathod PK, Mather MW, Vaidya AB.

Mol Biochem Parasitol. 2011 May;177(1):29-34. doi: 10.1016/j.molbiopara.2011.01.004. Epub 2011 Jan 18.

PMID:
21251930
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Branched tricarboxylic acid metabolism in Plasmodium falciparum.

Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M.

Nature. 2010 Aug 5;466(7307):774-8. doi: 10.1038/nature09301. Erratum in: Nature. 2011 Jan 20;469(7330):432. Retraction in: Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M. Nature. 2013 May 30;497(7451):652.

PMID:
20686576
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies.

Mather MW, Morrisey JM, Vaidya AB.

Mol Biochem Parasitol. 2010 Dec;174(2):150-3. doi: 10.1016/j.molbiopara.2010.07.006. Epub 2010 Jul 30.

PMID:
20674615
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Highly divergent mitochondrial ATP synthase complexes in Tetrahymena thermophila.

Balabaskaran Nina P, Dudkina NV, Kane LA, van Eyk JE, Boekema EJ, Mather MW, Vaidya AB.

PLoS Biol. 2010 Jul 13;8(7):e1000418. doi: 10.1371/journal.pbio.1000418.

PMID:
20644710
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Mitochondrial evolution and functions in malaria parasites.

Vaidya AB, Mather MW.

Annu Rev Microbiol. 2009;63:249-67. doi: 10.1146/annurev.micro.091208.073424. Review.

PMID:
19575561
[PubMed - indexed for MEDLINE]
13.

Mitochondria in malaria and related parasites: ancient, diverse and streamlined.

Mather MW, Vaidya AB.

J Bioenerg Biomembr. 2008 Oct;40(5):425-33. doi: 10.1007/s10863-008-9176-4. Epub 2008 Sep 24. Review.

PMID:
18814021
[PubMed - indexed for MEDLINE]
14.

The validity of mitochondrial dehydrogenases as antimalarial drug targets.

Vaidya AB, Painter HJ, Morrisey JM, Mather MW.

Trends Parasitol. 2008 Jan;24(1):8-9. Epub 2007 Nov 26. No abstract available.

PMID:
18023619
[PubMed - indexed for MEDLINE]
15.

Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum.

Painter HJ, Morrisey JM, Mather MW, Vaidya AB.

Nature. 2007 Mar 1;446(7131):88-91.

PMID:
17330044
[PubMed - indexed for MEDLINE]
16.

Mitochondrial drug targets in apicomplexan parasites.

Mather MW, Henry KW, Vaidya AB.

Curr Drug Targets. 2007 Jan;8(1):49-60. Review.

PMID:
17266530
[PubMed - indexed for MEDLINE]
17.

A post-genomic view of the mitochondrion in malaria parasites.

Vaidya AB, Mather MW.

Curr Top Microbiol Immunol. 2005;295:233-50. Review.

PMID:
16265893
[PubMed - indexed for MEDLINE]
18.

Uncovering the molecular mode of action of the antimalarial drug atovaquone using a bacterial system.

Mather MW, Darrouzet E, Valkova-Valchanova M, Cooley JW, McIntosh MT, Daldal F, Vaidya AB.

J Biol Chem. 2005 Jul 22;280(29):27458-65. Epub 2005 May 24.

PMID:
15917236
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Genome sequence of the human malaria parasite Plasmodium falciparum.

Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B.

Nature. 2002 Oct 3;419(6906):498-511.

PMID:
12368864
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The inhibition of calcium signaling in T lymphocytes from old mice results from enhanced activation of the mitochondrial permeability transition pore.

Mather MW, Rottenberg H.

Mech Ageing Dev. 2002 Mar 31;123(6):707-24.

PMID:
11850032
[PubMed - indexed for MEDLINE]

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