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Results: 1 to 20 of 217

1.

Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism.

Murray-Stewart T, Hanigan CL, Woster PM, Marton LJ, Casero RA Jr.

Mol Cancer Ther. 2013 Oct;12(10):2088-99. doi: 10.1158/1535-7163.MCT-13-0418. Epub 2013 Aug 13.

2.

Scanning the topography of polyamine blocker binding in an inwardly rectifying potassium channel.

Kurata HT, Akrouh A, Li JB, Marton LJ, Nichols CG.

J Biol Chem. 2013 Mar 1;288(9):6591-601. doi: 10.1074/jbc.M112.383794. Epub 2013 Jan 8.

3.

Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes.

Wu Y, Steinbergs N, Murray-Stewart T, Marton LJ, Casero RA.

Biochem J. 2012 Mar 15;442(3):693-701. doi: 10.1042/BJ20111271.

4.

Subtype and pathway specific responses to anticancer compounds in breast cancer.

Heiser LM, Sadanandam A, Kuo WL, Benz SC, Goldstein TC, Ng S, Gibb WJ, Wang NJ, Ziyad S, Tong F, Bayani N, Hu Z, Billig JI, Dueregger A, Lewis S, Jakkula L, Korkola JE, Durinck S, Pepin F, Guan Y, Purdom E, Neuvial P, Bengtsson H, Wood KW, Smith PG, Vassilev LT, Hennessy BT, Greshock J, Bachman KE, Hardwicke MA, Park JW, Marton LJ, Wolf DM, Collisson EA, Neve RM, Mills GB, Speed TP, Feiler HS, Wooster RF, Haussler D, Stuart JM, Gray JW, Spellman PT.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2724-9. doi: 10.1073/pnas.1018854108. Epub 2011 Oct 14.

5.

Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells.

Zhu Q, Huang Y, Marton LJ, Woster PM, Davidson NE, Casero RA Jr.

Amino Acids. 2012 Feb;42(2-3):887-98. doi: 10.1007/s00726-011-1004-1. Epub 2011 Jul 30.

6.

Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047.

Cirenajwis H, Smiljanic S, Honeth G, Hegardt C, Marton LJ, Oredsson SM.

Anticancer Drugs. 2010 Nov;21(10):897-906. doi: 10.1097/CAD.0b013e32833f2f77.

PMID:
20838207
7.

Polyamine analogues targeting epigenetic gene regulation.

Huang Y, Marton LJ, Woster PM, Casero RA.

Essays Biochem. 2009 Nov 4;46:95-110. doi: 10.1042/bse0460007. Review.

8.

A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047.

Kuo WL, Das D, Ziyad S, Bhattacharya S, Gibb WJ, Heiser LM, Sadanandam A, Fontenay GV, Hu Z, Wang NJ, Bayani N, Feiler HS, Neve RM, Wyrobek AJ, Spellman PT, Marton LJ, Gray JW.

BMC Med. 2009 Dec 14;7:77. doi: 10.1186/1741-7015-7-77.

9.

Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes.

Huang Y, Stewart TM, Wu Y, Baylin SB, Marton LJ, Perkins B, Jones RJ, Woster PM, Casero RA Jr.

Clin Cancer Res. 2009 Dec 1;15(23):7217-28. doi: 10.1158/1078-0432.CCR-09-1293. Epub 2009 Nov 24.

10.

The polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer.

Dredge K, Kink JA, Johnson RM, Bytheway I, Marton LJ.

Cancer Chemother Pharmacol. 2009 Dec;65(1):191-5. doi: 10.1007/s00280-009-1105-7. Epub 2009 Aug 15.

PMID:
19685053
11.

Gene expression analysis of HCT116 colon tumor-derived cells treated with the polyamine analog PG-11047.

Ignatenko NA, Yerushalmi HF, Pandey R, Kachel KL, Stringer DE, Marton LJ, Gerner EW.

Cancer Genomics Proteomics. 2009 May-Jun;6(3):161-75.

12.

Therapeutic evaluation of polyamine analogue drug candidates against Enterocytozoon bieneusi in a SCID mouse model.

Feng X, Reddy VK, Mayanja-Kizza H, Weiss LM, Marton LJ, Tzipori S.

Antimicrob Agents Chemother. 2009 Jun;53(6):2417-23. doi: 10.1128/AAC.01113-08. Epub 2009 Mar 16.

13.

K+ binding in the G-loop and water cavity facilitates Ba2+ movement in the Kir2.1 channel.

Chang HK, Marton LJ, Liang KK, Shieh RC.

Biochim Biophys Acta. 2009 Feb;1788(2):500-6. doi: 10.1016/j.bbamem.2008.10.016. Epub 2008 Nov 5.

14.

Blocker protection by short spermine analogs: refined mapping of the spermine binding site in a Kir channel.

Kurata HT, Diraviyam K, Marton LJ, Nichols CG.

Biophys J. 2008 Oct;95(8):3827-39. doi: 10.1529/biophysj.108.133256. Epub 2008 Jul 18.

15.

The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib.

Carew JS, Nawrocki ST, Reddy VK, Bush D, Rehg JE, Goodwin A, Houghton JA, Casero RA Jr, Marton LJ, Cleveland JL.

Cancer Res. 2008 Jun 15;68(12):4783-90. doi: 10.1158/0008-5472.CAN-07-6483.

16.

In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells.

Hacker A, Marton LJ, Sobolewski M, Casero RA Jr.

Cancer Chemother Pharmacol. 2008 Dec;63(1):45-53. doi: 10.1007/s00280-008-0706-x. Epub 2008 Feb 27.

17.

Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases.

Casero RA Jr, Marton LJ.

Nat Rev Drug Discov. 2007 May;6(5):373-90. Review.

PMID:
17464296
18.
19.

Antizyme and antizyme inhibitor activities influence cellular responses to polyamine analogs.

Mitchell JL, Thane TK, Sequeira JM, Marton LJ, Thokala R.

Amino Acids. 2007 Aug;33(2):291-7. Epub 2007 Apr 6.

PMID:
17410332
20.

Cryptosporidium parvum spermidine/spermine N1-acetyltransferase exhibits different characteristics from the host enzyme.

Yarlett N, Wu G, Waters WR, Harp JA, Wannemuehler MJ, Morada M, Athanasopoulos D, Martinez MP, Upton SJ, Marton LJ, Frydman BJ.

Mol Biochem Parasitol. 2007 Apr;152(2):170-80. Epub 2007 Jan 9.

PMID:
17289169
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