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Items: 1 to 20 of 36


Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction.

Milde R, Ritter J, Tennent GA, Loesch A, Martinez FO, Gordon S, Pepys MB, Verschoor A, Helming L.

Cell Rep. 2015 Dec 1;13(9):1937-48. doi: 10.1016/j.celrep.2015.10.065. Epub 2015 Nov 25.


Inflammation activation and resolution in human tendon disease.

Dakin SG, Martinez FO, Yapp C, Wells G, Oppermann U, Dean BJ, Smith RD, Wheway K, Watkins B, Roche L, Carr AJ.

Sci Transl Med. 2015 Oct 28;7(311):311ra173. doi: 10.1126/scitranslmed.aac4269.


G3BP1 restricts HIV-1 replication in macrophages and T-cells by sequestering viral RNA.

Cobos Jiménez V, Martinez FO, Booiman T, van Dort KA, van de Klundert MA, Gordon S, Geijtenbeek TB, Kootstra NA.

Virology. 2015 Dec;486:94-104. doi: 10.1016/j.virol.2015.09.007. Epub 2015 Sep 29.


CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.

Hammitzsch A, Tallant C, Fedorov O, O'Mahony A, Brennan PE, Hay DA, Martinez FO, Al-Mossawi MH, de Wit J, Vecellio M, Wells C, Wordsworth P, Müller S, Knapp S, Bowness P.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10768-73. doi: 10.1073/pnas.1501956112. Epub 2015 Aug 10.


Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription.

Alasoo K, Martinez FO, Hale C, Gordon S, Powrie F, Dougan G, Mukhopadhyay S, Gaffney DJ.

Sci Rep. 2015 Jul 30;5:12524. doi: 10.1038/srep12524.


Cholesterol loading reprograms the microRNA-143/145-myocardin axis to convert aortic smooth muscle cells to a dysfunctional macrophage-like phenotype.

Vengrenyuk Y, Nishi H, Long X, Ouimet M, Savji N, Martinez FO, Cassella CP, Moore KJ, Ramsey SA, Miano JM, Fisher EA.

Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):535-46. doi: 10.1161/ATVBAHA.114.304029. Epub 2015 Jan 8.


The evolution of our understanding of macrophages and translation of findings toward the clinic.

Martinez FO, Gordon S.

Expert Rev Clin Immunol. 2015 Jan;11(1):5-13. doi: 10.1586/1744666X.2015.985658. Epub 2014 Dec 1. Review.


Hepatic Localization of Macrophage Phenotypes during Fibrogenesis and Resolution of Fibrosis in Mice and Humans.

Beljaars L, Schippers M, Reker-Smit C, Martinez FO, Helming L, Poelstra K, Melgert BN.

Front Immunol. 2014 Sep 8;5:430. doi: 10.3389/fimmu.2014.00430. eCollection 2014.


Macrophage activation and polarization: nomenclature and experimental guidelines.

Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, Natoli G, Saeij JP, Schultze JL, Shirey KA, Sica A, Suttles J, Udalova I, van Ginderachter JA, Vogel SN, Wynn TA.

Immunity. 2014 Jul 17;41(1):14-20. doi: 10.1016/j.immuni.2014.06.008.


The M1 and M2 paradigm of macrophage activation: time for reassessment.

Martinez FO, Gordon S.

F1000Prime Rep. 2014 Mar 3;6:13. doi: 10.12703/P6-13. eCollection 2014. Review.


Chronic exposure to glucocorticoids shapes gene expression and modulates innate and adaptive activation pathways in macrophages with distinct changes in leukocyte attraction.

van de Garde MD, Martinez FO, Melgert BN, Hylkema MN, Jonkers RE, Hamann J.

J Immunol. 2014 Feb 1;192(3):1196-208. doi: 10.4049/jimmunol.1302138. Epub 2014 Jan 6.


WT1 regulates the expression of inhibitory chemokines during heart development.

Velecela V, Lettice LA, Chau YY, Slight J, Berry RL, Thornburn A, Gunst QD, van den Hoff M, Reina M, Martínez FO, Hastie ND, Martínez-Estrada OM.

Hum Mol Genet. 2013 Dec 20;22(25):5083-95. doi: 10.1093/hmg/ddt358. Epub 2013 Jul 29.


Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences.

Martinez FO, Helming L, Milde R, Varin A, Melgert BN, Draijer C, Thomas B, Fabbri M, Crawshaw A, Ho LP, Ten Hacken NH, Cobos Jiménez V, Kootstra NA, Hamann J, Greaves DR, Locati M, Mantovani A, Gordon S.

Blood. 2013 Feb 28;121(9):e57-69. doi: 10.1182/blood-2012-06-436212. Epub 2013 Jan 4.


Analysis of gene expression and gene silencing in human macrophages.

Martinez FO.

Curr Protoc Immunol. 2012 Feb;Chapter 14:Unit 14.28.1-23. doi: 10.1002/0471142735.im1428s96.


Regulators of macrophage activation.

Martinez FO.

Eur J Immunol. 2011 Jun;41(6):1531-4. doi: 10.1002/eji.201141670. Epub 2011 May 24.


Alternative activation of macrophages: mechanism and functions.

Gordon S, Martinez FO.

Immunity. 2010 May 28;32(5):593-604. doi: 10.1016/j.immuni.2010.05.007. Review.


The transcriptome of human monocyte subsets begins to emerge.

Martinez FO.

J Biol. 2009;8(11):99. doi: 10.1186/jbiol206. Epub 2009 Dec 23. Review.


Alternative activation of macrophages: an immunologic functional perspective.

Martinez FO, Helming L, Gordon S.

Annu Rev Immunol. 2009;27:451-83. doi: 10.1146/annurev.immunol.021908.132532. Review.


Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis.

Heinsbroek SE, Taylor PR, Martinez FO, Martinez-Pomares L, Brown GD, Gordon S.

PLoS Pathog. 2008 Nov;4(11):e1000218. doi: 10.1371/journal.ppat.1000218. Epub 2008 Nov 28.


Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.

Helming L, Tomasello E, Kyriakides TR, Martinez FO, Takai T, Gordon S, Vivier E.

Sci Signal. 2008 Oct 28;1(43):ra11. doi: 10.1126/scisignal.1159665.

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