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TGF-β/BMP proteins as therapeutic targets in renal fibrosis. Where have we arrived after 25years of trials and tribulations?

Muñoz-Félix JM, González-Núñez M, Martínez-Salgado C, López-Novoa JM.

Pharmacol Ther. 2015 Oct 19. pii: S0163-7258(15)00184-9. doi: 10.1016/j.pharmthera.2015.10.003. [Epub ahead of print] Review.


Increased Klk9 Urinary Excretion Is Associated to Hypertension-Induced Cardiovascular Damage and Renal Alterations.

Blázquez-Medela AM, García-Sánchez O, Quirós Y, Blanco-Gozalo V, Prieto-García L, Sancho-Martínez SM, Romero M, Duarte JM, López-Hernández FJ, López-Novoa JM, Martínez-Salgado C.

Medicine (Baltimore). 2015 Oct;94(41):e1617. doi: 10.1097/MD.0000000000001617.


Plasma Cardiotrophin-1 as a Marker of Hypertension and Diabetes-Induced Target Organ Damage and Cardiovascular Risk.

Gamella-Pozuelo L, Fuentes-Calvo I, Gómez-Marcos MA, Recio-Rodriguez JI, Agudo-Conde C, Fernández-Martín JL, Cannata-Andía JB, López-Novoa JM, García-Ortiz L, Martínez-Salgado C.

Medicine (Baltimore). 2015 Jul;94(30):e1218. doi: 10.1097/MD.0000000000001218.


L-Endoglin overexpression increases renal fibrosis after unilateral ureteral obstruction.

Oujo B, Muñoz-Félix JM, Arévalo M, Núñez-Gómez E, Pérez-Roque L, Pericacho M, González-Núñez M, Langa C, Martínez-Salgado C, Perez-Barriocanal F, Bernabeu C, Lopez-Novoa JM.

PLoS One. 2014 Oct 14;9(10):e110365. doi: 10.1371/journal.pone.0110365. eCollection 2014.


Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats.

Blázquez-Medela AM, García-Sánchez O, Blanco-Gozalo V, Quiros Y, Montero MJ, Martínez-Salgado C, López-Novoa JM, López-Hernández FJ.

PLoS One. 2014 Aug 22;9(8):e105988. doi: 10.1371/journal.pone.0105988. eCollection 2014.


[The place of the individual in the field of health: lessons from qualitative investigation].

Martínez-Salgado C.

Cien Saude Colet. 2014 Apr;19(4):1095-102. Spanish.


Relationship between target organ damage and blood pressure, retinal vessel calibre, oxidative stress and polymorphisms in VAV-2 and VAV-3 genes in patients with hypertension: a case-control study protocol (LOD-Hipertension).

Gomez-Marcos MA, Gonzalez-Sarmiento R, Recio-Rodríguez JI, Agudo-Conde C, Gamella-Pozuelo L, Perretta-Tejedor N, Martínez-Salgado C, García-Ortiz L.

BMJ Open. 2014 Apr 3;4(4):e005112. doi: 10.1136/bmjopen-2014-005112.


ALK1 heterozygosity increases extracellular matrix protein expression, proliferation and migration in fibroblasts.

Muñoz-Félix JM, Perretta-Tejedor N, Eleno N, López-Novoa JM, Martínez-Salgado C.

Biochim Biophys Acta. 2014 Jun;1843(6):1111-22. doi: 10.1016/j.bbamcr.2014.02.017. Epub 2014 Mar 1.


Influence of body mass index on the association of weight changes with mortality in hemodialysis patients.

Cabezas-Rodriguez I, Carrero JJ, Zoccali C, Qureshi AR, Ketteler M, Floege J, London G, Locatelli F, Gorriz JL, Rutkowski B, Memmos D, Ferreira A, Covic A, Teplan V, Bos WJ, Kramar R, Pavlovic D, Goldsmith D, Nagy J, Benedik M, Verbeelen D, Tielemans C, Wüthrich RP, Martin PY, Martínez-Salgado C, Fernández-Martín JL, Cannata-Andia JB.

Clin J Am Soc Nephrol. 2013 Oct;8(10):1725-33. doi: 10.2215/CJN.10951012. Epub 2013 Sep 5.


Stomatin-domain protein interactions with acid-sensing ion channels modulate nociceptor mechanosensitivity.

Moshourab RA, Wetzel C, Martinez-Salgado C, Lewin GR.

J Physiol. 2013 Nov 15;591(Pt 22):5555-74. doi: 10.1113/jphysiol.2013.261180. Epub 2013 Aug 19.


Concerted action of ANP and dopamine D1-receptor to regulate sodium homeostasis in nephrotic syndrome.

Fernandes-Cerqueira C, Sampaio-Maia B, Quelhas-Santos J, Moreira-Rodrigues M, Simões-Silva L, Blazquez-Medela AM, Martinez-Salgado C, Lopez-Novoa JM, Pestana M.

Biomed Res Int. 2013;2013:397391. doi: 10.1155/2013/397391. Epub 2013 Jul 15.


Heterozygous disruption of activin receptor-like kinase 1 is associated with increased renal fibrosis in a mouse model of obstructive nephropathy.

Muñoz-Félix JM, López-Novoa JM, Martínez-Salgado C.

Kidney Int. 2014 Feb;85(2):319-32. doi: 10.1038/ki.2013.292. Epub 2013 Aug 14.


The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts.

Fuentes-Calvo I, Crespo P, Santos E, López-Novoa JM, Martínez-Salgado C.

Biochim Biophys Acta. 2013 Dec;1833(12):2734-44. doi: 10.1016/j.bbamcr.2013.07.008. Epub 2013 Jul 18.


TNF-related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras-dependent proliferation of cultured renal fibroblast.

Ucero AC, Benito-Martin A, Fuentes-Calvo I, Santamaria B, Blanco J, Lopez-Novoa JM, Ruiz-Ortega M, Egido J, Burkly LC, Martinez-Salgado C, Ortiz A.

Biochim Biophys Acta. 2013 Oct;1832(10):1744-55. doi: 10.1016/j.bbadis.2013.05.032. Epub 2013 Jun 6.


Functional specific roles of H-ras and N-ras. A proteomic approach using knockout cell lines.

Ferreira L, Fuentes-Calvo I, Muñoz-Félix JM, Muñiz-Martín C, Sánchez-Juanes F, Raposo C, González-Buitrago JM, López-Novoa JM, Martínez-Salgado C.

Electrophoresis. 2012 May;33(9-10):1385-96. doi: 10.1002/elps.201100606.


[Sampling in qualitative research: basic principles and some controversies].

Martínez-Salgado C.

Cien Saude Colet. 2012 Mar;17(3):613-9. Spanish.


H-Ras isoform modulates extracellular matrix synthesis, proliferation, and migration in fibroblasts.

Fuentes-Calvo I, Blázquez-Medela AM, Eleno N, Santos E, López-Novoa JM, Martínez-Salgado C.

Am J Physiol Cell Physiol. 2012 Feb 15;302(4):C686-97. doi: 10.1152/ajpcell.00103.2011. Epub 2011 Nov 16.


Osteoprotegerin is associated with cardiovascular risk in hypertension and/or diabetes.

Blázquez-Medela AM, García-Ortiz L, Gómez-Marcos MA, Recio-Rodriguez JI, Sánchez-Rodríguez A, López-Novoa JM, Martínez-Salgado C.

Eur J Clin Invest. 2012 May;42(5):548-56. doi: 10.1111/j.1365-2362.2011.02619.x. Epub 2011 Nov 4.


Osteoprotegerin and diabetes-associated pathologies.

Blázquez-Medela AM, López-Novoa JM, Martínez-Salgado C.

Curr Mol Med. 2011 Jul;11(5):401-16. Review.


Peripheral and central arterial pressure and its relationship to vascular target organ damage in carotid artery, retina and arterial stiffness. Development and validation of a tool. The Vaso risk study.

Garcia-Ortiz L, Ramos-Delgado E, Recio-Rodriguez JI, Agudo-Conde C, Martínez-Salgado C, Patino-Alonso MC, Rodriguez-Sanchez E, Gomez-Marcos MA; Vaso risk group.

BMC Public Health. 2011 Apr 27;11:266. doi: 10.1186/1471-2458-11-266.

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