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Results: 1 to 20 of 228

1.

Exploring the interaction between the antiallergic drug, tranilast and human serum albumin: Insights from calorimetric, spectroscopic and modeling studies.

Tayyab S, Zaroog MS, Feroz SR, Mohamad SB, Malek SN.

Int J Pharm. 2015 Jun 30;491(1-2):352-358. doi: 10.1016/j.ijpharm.2015.06.042. [Epub ahead of print]

PMID:
26142245
2.

Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner.

He S, Malik B, Borkin D, Miao H, Shukla S, Kempinska K, Purohit T, Wang J, Chen L, Parkin B, Malek SN, Danet-Desnoyers G, Muntean AG, Cierpicki T, Grembecka J.

Leukemia. 2015 Jun 18. doi: 10.1038/leu.2015.144. [Epub ahead of print] No abstract available.

PMID:
26084867
3.

Supramolecular interaction of 6-shogaol, a therapeutic agent of Zingiber officinale with human serum albumin as elucidated by spectroscopic, calorimetric and molecular docking methods.

Feroz SR, Mohamad SB, Lee GS, Malek SN, Tayyab S.

Phytomedicine. 2015 Jun 1;22(6):621-30. doi: 10.1016/j.phymed.2015.03.016. Epub 2015 Apr 9.

PMID:
26055127
4.

High-performance infrared light trapping in nano-needle structured p⁺ SnOx (x  ≤  1)/thin film n-Ge photodiodes on Si.

Wang X, Wong A, Malek S, Cai Y, Liu J.

Opt Lett. 2015 Jun 1;40(11):2603-6. doi: 10.1364/OL.40.002603.

PMID:
26030568
5.

Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1.

Gazzard L, Williams K, Chen H, Axford L, Blackwood E, Burton B, Chapman K, Crackett P, Drobnick J, Ellwood C, Epler J, Flagella M, Gancia E, Gill M, Goodacre S, Halladay J, Hewitt J, Hunt H, Kintz S, Lyssikatos J, Macleod C, Major S, Médard G, Narukulla R, Ramiscal J, Schmidt S, Seward E, Wiesmann C, Wu P, Yee S, Yen I, Malek S.

J Med Chem. 2015 Jun 25;58(12):5053-74. doi: 10.1021/acs.jmedchem.5b00464. Epub 2015 Jun 4.

PMID:
25988399
6.

A Quantum Chemical and Statistical Study of Cytotoxic Activity of Compounds Isolated from Curcuma zedoaria.

Hamdi OA, Anouar el H, Shilpi JA, Trabolsy ZB, Zain SB, Zakaria NS, Zulkefeli M, Weber JF, Malek SN, Rahman SN, Awang K.

Int J Mol Sci. 2015 Apr 27;16(5):9450-68. doi: 10.3390/ijms16059450.

7.

Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells.

Jones M, Chase J, Brinkmeier M, Xu J, Weinberg DN, Schira J, Friedman A, Malek S, Grembecka J, Cierpicki T, Dou Y, Camper SA, Maillard I.

J Clin Invest. 2015 May;125(5):2007-20. doi: 10.1172/JCI78124. Epub 2015 Apr 13.

PMID:
25866973
8.

Crystallization of Lennard-Jones nanodroplets: From near melting to deeply supercooled.

Malek SM, Morrow GP, Saika-Voivod I.

J Chem Phys. 2015 Mar 28;142(12):124506. doi: 10.1063/1.4915917.

PMID:
25833595
9.

Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies.

Peterson LF, Sun H, Liu Y, Potu H, Kandarpa M, Ermann M, Courtney SM, Young M, Showalter HD, Sun D, Jakubowiak A, Malek SN, Talpaz M, Donato NJ.

Blood. 2015 Jun 4;125(23):3588-97. doi: 10.1182/blood-2014-10-605584. Epub 2015 Mar 26.

PMID:
25814533
10.
11.

Integrated genomic profiling, therapy response, and survival in adult acute myelogenous leukemia.

Parkin B, Ouillette P, Yildiz M, Saiya-Cork K, Shedden K, Malek SN.

Clin Cancer Res. 2015 May 1;21(9):2045-56. doi: 10.1158/1078-0432.CCR-14-0921. Epub 2015 Feb 4.

PMID:
25652455
12.

A comparative analysis on the binding characteristics of various mammalian albumins towards a multitherapeutic agent, pinostrobin.

Feroz SR, Sumi RA, Malek SN, Tayyab S.

Exp Anim. 2015;64(2):101-8. doi: 10.1538/expanim.14-0053. Epub 2014 Dec 16.

13.

Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase.

Fauber BP, Dragovich PS, Chen J, Corson LB, Ding CZ, Eigenbrot C, Labadie S, Malek S, Peterson D, Purkey HE, Robarge K, Sideris S, Ultsch M, Wei B, Yen I, Yue Q, Zhou A.

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5683-7. doi: 10.1016/j.bmcl.2014.10.067. Epub 2014 Oct 27.

PMID:
25467161
14.

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.

Labadie S, Dragovich PS, Chen J, Fauber BP, Boggs J, Corson LB, Ding CZ, Eigenbrot C, Ge H, Ho Q, Lai KW, Ma S, Malek S, Peterson D, Purkey HE, Robarge K, Salphati L, Sideris S, Ultsch M, VanderPorten E, Wei B, Xu Q, Yen I, Yue Q, Zhang H, Zhang X, Zhou A.

Bioorg Med Chem Lett. 2015 Jan 1;25(1):75-82. Epub 2014 Nov 10.

PMID:
25466195
15.

Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1.

Gazzard L, Appleton B, Chapman K, Chen H, Clark K, Drobnick J, Goodacre S, Halladay J, Lyssikatos J, Schmidt S, Sideris S, Wiesmann C, Williams K, Wu P, Yen I, Malek S.

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5704-9. doi: 10.1016/j.bmcl.2014.10.063. Epub 2014 Oct 27.

PMID:
25453805
16.

Activating STAT6 mutations in follicular lymphoma.

Yildiz M, Li H, Bernard D, Amin NA, Ouillette P, Jones S, Saiya-Cork K, Parkin B, Jacobi K, Shedden K, Wang S, Chang AE, Kaminski MS, Malek SN.

Blood. 2015 Jan 22;125(4):668-79. doi: 10.1182/blood-2014-06-582650. Epub 2014 Nov 26.

PMID:
25428220
17.

Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation.

Hanan EJ, Eigenbrot C, Bryan MC, Burdick DJ, Chan BK, Chen Y, Dotson J, Heald RA, Jackson PS, La H, Lainchbury MD, Malek S, Purkey HE, Schaefer G, Schmidt S, Seward EM, Sideris S, Tam C, Wang S, Yeap SK, Yen I, Yin J, Yu C, Zilberleyb I, Heffron TP.

J Med Chem. 2014 Dec 11;57(23):10176-91. doi: 10.1021/jm501578n. Epub 2014 Nov 20.

PMID:
25383627
18.

A questionnaire examining attitudes of collegiate athletes toward doping and pharmacists as information providers.

Malek S, Taylor J, Mansell K.

Can Pharm J (Ott). 2014 Nov;147(6):352-8. doi: 10.1177/1715163514552559.

19.

Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling.

Haling JR, Sudhamsu J, Yen I, Sideris S, Sandoval W, Phung W, Bravo BJ, Giannetti AM, Peck A, Masselot A, Morales T, Smith D, Brandhuber BJ, Hymowitz SG, Malek S.

Cancer Cell. 2014 Sep 8;26(3):402-13. doi: 10.1016/j.ccr.2014.07.007. Epub 2014 Aug 21.

PMID:
25155755
20.

Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.

Dragovich PS, Fauber BP, Boggs J, Chen J, Corson LB, Ding CZ, Eigenbrot C, Ge H, Giannetti AM, Hunsaker T, Labadie S, Li C, Liu Y, Liu Y, Ma S, Malek S, Peterson D, Pitts KE, Purkey HE, Robarge K, Salphati L, Sideris S, Ultsch M, VanderPorten E, Wang J, Wei B, Xu Q, Yen I, Yue Q, Zhang H, Zhang X, Zhou A.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3764-71. doi: 10.1016/j.bmcl.2014.06.076. Epub 2014 Jul 1.

PMID:
25037916
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