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Neutrophil gelatinase associated lipocalin in acute kidney injury.
Peacock WF 4th, Maisel A, Kim J, Ronco C. Peacock WF 4th, et al. Among authors: maisel a. Postgrad Med. 2013 Nov;125(6):82-93. doi: 10.3810/pgm.2013.11.2715. Postgrad Med. 2013. PMID: 24200764 Review.
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is a member of the lipocalin family of proteins. Usually, NGAL is produced and secreted by kidney tubule cells at low levels, but the amount produced and secreted into the urine and serum increases dramat …
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is a member of the lipocalin family of proteins. Usually, NGAL i …
Neutrophil gelatinase-associated lipocalin as a biomarker of cardiovascular disease: a systematic review.
Cruz DN, Gaiao S, Maisel A, Ronco C, Devarajan P. Cruz DN, et al. Among authors: maisel a. Clin Chem Lab Med. 2012;50(9):1533-45. doi: 10.1515/cclm-2012-0307. Clin Chem Lab Med. 2012. PMID: 23089611 Free PMC article. Review.
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury (AKI). Recently, elevated NGAL levels have also been reported in heart failure, coronary heart disease, and stroke. ...Our aim was to synthesize the current evidence …
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury (AKI). Recently, elevated NGAL
The appropriate use of biomarkers in heart failure.
Chowdhury P, Choudhary R, Maisel A. Chowdhury P, et al. Among authors: maisel a. Med Clin North Am. 2012 Sep;96(5):901-13. doi: 10.1016/j.mcna.2012.07.002. Med Clin North Am. 2012. PMID: 22980054 Review.
Natriuretic peptides and troponins have been extensively studied and used in heart failure, and their value has been extensively discussed. Renal markers, such as cystasin-C, NGAL, and KIM-1, have shown growing utility in heart failure. The activation of compensatory pathw …
Natriuretic peptides and troponins have been extensively studied and used in heart failure, and their value has been extensively discussed. …
Proenkephalin (PENK) as a Novel Biomarker for Kidney Function.
Beunders R, Struck J, Wu AHB, Zarbock A, Di Somma S, Mehta RL, Koyner JL, Nadim MK, Maisel AS, Murray PT, Neath SX, Jaffe A, Pickkers P. Beunders R, et al. Among authors: maisel as. J Appl Lab Med. 2017 Nov 1;2(3):400-412. doi: 10.1373/jalm.2017.023598. J Appl Lab Med. 2017. PMID: 33636859
In recent years, several biomarkers have been put forward (e.g., NGAL, KIM-1, TIMP-2*IGFBP-7), but clinical implementation is limited up to now. ...
In recent years, several biomarkers have been put forward (e.g., NGAL, KIM-1, TIMP-2*IGFBP-7), but clinical implementation is limited …
Neutrophil gelatinase-associated lipocalin as diagnostic and prognostic tool for cardiovascular disease and heart failure.
Iqbal N, Choudhary R, Chan J, Wentworth B, Higginbotham E, Maisel AS. Iqbal N, et al. Among authors: maisel as. Expert Opin Med Diagn. 2013 Mar;7(2):209-20. doi: 10.1517/17530059.2013.763795. Epub 2013 Jan 25. Expert Opin Med Diagn. 2013. PMID: 23530890 Review.
EXPERT OPINION: The authors believe that NGAL should be used as a clinical diagnostic tool to predict outcomes in patients with CVD. Growing evidence has illustrated the biological role that neutrophils, such as NGAL, play in inflammation and atherosclerosis. Furthe …
EXPERT OPINION: The authors believe that NGAL should be used as a clinical diagnostic tool to predict outcomes in patients with CVD. …
The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure.
Horiuchi YU, Wettersten N, Vanveldhuisen DJ, Mueller C, Nowak R, Hogan C, Kontos MC, Cannon CM, Birkhahn R, Vilke GM, Mahon N, Nuñez J, Briguori C, Duff S, Murray PT, Maisel A. Horiuchi YU, et al. Among authors: maisel a. J Card Fail. 2023 Aug;29(8):1121-1131. doi: 10.1016/j.cardfail.2023.03.029. Epub 2023 Apr 29. J Card Fail. 2023. PMID: 37127240
METHODS AND RESULTS: B-type natriuretic peptide (BNP), high-sensitivity cardiac troponin I (hs-cTnI), galectin-3, serum neutrophil gelatinase-associated lipocalin (sNGAL), and urine NGAL were measured serially in patients with AHF during hospitalization in the AKINESIS (Ac …
METHODS AND RESULTS: B-type natriuretic peptide (BNP), high-sensitivity cardiac troponin I (hs-cTnI), galectin-3, serum neutrophil gelatinas …
Neutrophil Gelatinase-Associated Lipocalin for Acute Kidney Injury During Acute Heart Failure Hospitalizations: The AKINESIS Study.
Maisel AS, Wettersten N, van Veldhuisen DJ, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos MC, Cannon CM, Müller GA, Birkhahn R, Clopton P, Taub P, Vilke GM, McDonald K, Mahon N, Nuñez J, Briguori C, Passino C, Murray PT. Maisel AS, et al. J Am Coll Cardiol. 2016 Sep 27;68(13):1420-1431. doi: 10.1016/j.jacc.2016.06.055. J Am Coll Cardiol. 2016. PMID: 27659464 Free article.
There were 235 adverse events in 144 subjects. The first NGAL was a better predictor than peak NGAL, but similar to the first creatinine (areas under the curve: 0.691, 0.653, and 0.686, respectively). ...The use of plasma NGAL to diagnose acute kidney injury …
There were 235 adverse events in 144 subjects. The first NGAL was a better predictor than peak NGAL, but similar to the first …
Short-term prognostic implications of serum and urine neutrophil gelatinase-associated lipocalin in acute heart failure: findings from the AKINESIS study.
Wettersten N, Horiuchi Y, van Veldhuisen DJ, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos MC, Cannon CM, Müeller GA, Birkhahn R, Taub P, Vilke GM, Barnett O, McDonald K, Mahon N, Nuñez J, Briguori C, Passino C, Maisel A, Murray PT. Wettersten N, et al. Among authors: maisel a. Eur J Heart Fail. 2020 Feb;22(2):251-263. doi: 10.1002/ejhf.1642. Epub 2019 Dec 21. Eur J Heart Fail. 2020. PMID: 31863682 Free article.
The present study aimed to determine if serum NGAL (sNGAL) or urine NGAL (uNGAL) is superior to creatinine for predicting short-term outcomes in AHF. ...NGAL was not predictive of the composite endpoint in multivariate analysis. ...
The present study aimed to determine if serum NGAL (sNGAL) or urine NGAL (uNGAL) is superior to creatinine for predicting shor …
B-type natriuretic peptide trend predicts clinical significance of worsening renal function in acute heart failure.
Wettersten N, Horiuchi Y, van Veldhuisen DJ, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos MC, Cannon CM, Müeller GA, Birkhahn R, Taub P, Vilke GM, Barnett O, McDonald K, Mahon N, Nuñez J, Briguori C, Passino C, Murray PT, Maisel A. Wettersten N, et al. Among authors: maisel a. Eur J Heart Fail. 2019 Dec;21(12):1553-1560. doi: 10.1002/ejhf.1627. Epub 2019 Nov 25. Eur J Heart Fail. 2019. PMID: 31769140 Free article.
We investigated the relationship between WRF and a decrease in BNP with in-hospital and 1-year mortality in AHF. METHODS AND RESULTS: The Acute Kidney Injury NGAL Evaluation of Symptomatic heart faIlure Study (AKINESIS) was a prospective, international, multicentre study o …
We investigated the relationship between WRF and a decrease in BNP with in-hospital and 1-year mortality in AHF. METHODS AND RESULTS: The Ac …
Opinion paper on utility of point-of-care biomarkers in the emergency department pathways decision making.
Di Somma S, Zampini G, Vetrone F, Soto-Ruiz KM, Magrini L, Cardelli P, Ronco C, Maisel A, Peacock FW. Di Somma S, et al. Among authors: maisel a. Clin Chem Lab Med. 2014 Oct;52(10):1401-7. doi: 10.1515/cclm-2014-0267. Clin Chem Lab Med. 2014. PMID: 24864300 Free article.
With improvements in technology, point-of-care testing (POCT) systems facilitate the efficient and high-throughput evaluation of biomarkers, such as troponin (cTn), brain natriuretic peptide (BNP) and neutrophil gelatinase-associated lipocalin (NGAL). In this context, POCT …
With improvements in technology, point-of-care testing (POCT) systems facilitate the efficient and high-throughput evaluation of biomarkers, …
15 results