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Items: 1 to 20 of 376

1.

Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance.

Gerhard DS, Clemons PA, Shamji AF, Hon C, Wagner BK, Schreiber SL, Krasnitz A, Sordella R, Sander C, Lowe SW, Powers S, Smith K, Aburi M, Iavarone A, Lasorella A, Silva J, Stockwell BR, Califano A, Boehm JS, Vazquez F, Weir BA, Hahn WC, Khuri FR, Moreno CS, Johns M, Fu H, Nikolova O, Mendez E, Gadi VK, Margolin AA, Grandori C, Kemp CJ, Warren EH, Riddell SR, McIntosh MW, Gevaert O, Kuo CJ, Ji HP, Dhruv H, Finlay D, Kiefer J, Kim S, Vuori K, Berens ME, Hangauer M, Boettcher M, Weissman JS, Bivona TG, Bandyopadhyay S, McManus MT, McCormick F, Aksoy O, Simonds EF, Zheng T, Chen J, An Z, Balmain A, Weiss WA, Chen K, Liang H, Scott KL, Mills GB, Posner BA, MacMillan J, Minna J, White M, Roth MG, Jagu S, Mazerik J.

Mol Cancer Res. 2016 Jul 11. pii: molcanres.0090.2016. [Epub ahead of print]

PMID:
27401613
2.

One-Pot Synthesis of 5-Hydroxy-4H-1,3-thiazin-4-ones: Structure Revision, Synthesis, and NMR Shift Dependence of Thiasporine A.

Seitz T, Fu P, Haut FL, Adam L, Habicht M, Lentz D, MacMillan JB, Christmann M.

Org Lett. 2016 Jul 1;18(13):3070-3. doi: 10.1021/acs.orglett.6b01166. Epub 2016 Jun 10.

PMID:
27286418
3.

Rifamycin Biosynthetic Congeners: Isolation and Total Synthesis of Rifsaliniketal and Total Synthesis of Salinisporamycin and Saliniketals A and B.

Feng Y, Liu J, Carrasco YP, MacMillan JB, De Brabander JK.

J Am Chem Soc. 2016 Jun 8;138(22):7130-42. doi: 10.1021/jacs.6b03248. Epub 2016 May 27.

PMID:
27232659
4.

Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR.

Sato S, Jung H, Nakagawa T, Pawlosky R, Takeshima T, Lee WR, Sakiyama H, Laxman S, Wynn RM, Tu BP, MacMillan JB, De Brabander JK, Veech RL, Uyeda K.

J Biol Chem. 2016 May 13;291(20):10515-27. doi: 10.1074/jbc.M115.708982. Epub 2016 Mar 16.

PMID:
26984404
5.

Structure Elucidation of Nigricanoside A Through Enantioselective Total Synthesis.

Chen J, Koswatta P, DeBergh JR, Fu P, Pan E, MacMillan JB, Ready JM.

Chem Sci. 2015 May 1;6(5):2932-2937. Epub 2015 Mar 12.

6.

Discovery, Characterization, and Analogue Synthesis of Bohemamine Dimers Generated by Non-enzymatic Biosynthesis.

Fu P, Legako A, La S, MacMillan JB.

Chemistry. 2016 Mar 1;22(10):3491-3495. doi: 10.1002/chem.201600024. Epub 2016 Feb 2.

PMID:
26834079
7.

Detailed Mechanistic Study of the Non-enzymatic Formation of the Discoipyrrole Family of Natural Products.

Colosimo DA, MacMillan JB.

J Am Chem Soc. 2016 Feb 24;138(7):2383-8. doi: 10.1021/jacs.5b13320. Epub 2016 Feb 11.

PMID:
26824832
8.

Effective number of breeders, effective population size and their relationship with census size in an iteroparous species, Salvelinus fontinalis.

Ruzzante DE, McCracken GR, Parmelee S, Hill K, Corrigan A, MacMillan J, Walde SJ.

Proc Biol Sci. 2016 Jan 27;283(1823). pii: 20152601. doi: 10.1098/rspb.2015.2601.

PMID:
26817773
9.

ICU Bedside Nurses' Involvement in Palliative Care Communication: A Multicenter Survey.

Anderson WG, Puntillo K, Boyle D, Barbour S, Turner K, Cimino J, Moore E, Noort J, MacMillan J, Pearson D, Grywalski M, Liao S, Ferrell B, Meyer J, O'Neil-Page E, Cain J, Herman H, Mitchell W, Pantilat S.

J Pain Symptom Manage. 2016 Mar;51(3):589-596.e2. doi: 10.1016/j.jpainsymman.2015.11.003. Epub 2015 Nov 18.

PMID:
26596882
10.

Physiologically based modeling of lead kinetics: a pilot study using data from a Canadian population.

MacMillan JW, Behinaein S, Chettle DR, Inskip M, McNeill FE, Manton WI, Healey N, Fisher M, Arbuckle TE, Fleming DE.

Environ Sci Process Impacts. 2015 Dec;17(12):2122-33. doi: 10.1039/c5em00517e.

PMID:
26565959
11.

1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus.

Fu P, La S, MacMillan JB.

J Nat Prod. 2016 Mar 25;79(3):455-62. doi: 10.1021/acs.jnatprod.5b00604. Epub 2015 Oct 21.

PMID:
26489038
12.

AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival.

Fisher KW, Das B, Kim HS, Clymer BK, Gehring D, Smith DR, Costanzo-Garvey DL, Fernandez MR, Brattain MG, Kelly DL, MacMillan J, White MA, Lewis RE.

Mol Cell Biol. 2015 Nov;35(22):3866-79. doi: 10.1128/MCB.00528-15. Epub 2015 Sep 8.

13.

Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2.

Scheuermann TH, Stroud D, Sleet CE, Bayeh L, Shokri C, Wang H, Caldwell CG, Longgood J, MacMillan JB, Bruick RK, Gardner KH, Tambar UK.

J Med Chem. 2015 Aug 13;58(15):5930-41. doi: 10.1021/acs.jmedchem.5b00529. Epub 2015 Jul 30.

PMID:
26226049
14.

Total Syntheses and Biological Evaluation of Both Enantiomers of Several Hydroxylated Dimeric Nuphar Alkaloids.

Korotkov A, Li H, Chapman CW, Xue H, MacMillan JB, Eastman A, Wu J.

Angew Chem Int Ed Engl. 2015 Sep 1;54(36):10604-7. doi: 10.1002/anie.201503934. Epub 2015 Jul 16.

PMID:
26205039
15.

Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived Streptomyces spinoverrucosus.

Fu P, MacMillan JB.

Org Lett. 2015 Jun 19;17(12):3046-9. doi: 10.1021/acs.orglett.5b01328. Epub 2015 May 29.

16.

Palliative and End-of-Life Ethical Dilemmas in the Intensive Care Unit.

Wiegand DL, MacMillan J, dos Santos MR, Bousso RS.

AACN Adv Crit Care. 2015 Apr-Jun;26(2):142-50. doi: 10.1097/NCI.0000000000000085.

PMID:
25898882
17.

Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B.

Potts MB, McMillan EA, Rosales TI, Kim HS, Ou YH, Toombs JE, Brekken RA, Minden MD, MacMillan JB, White MA.

Nat Chem Biol. 2015 Jun;11(6):401-8. doi: 10.1038/nchembio.1797. Epub 2015 Apr 13.

18.

Structural and mechanistic roles of novel chemical ligands on the SdiA quorum-sensing transcription regulator.

Nguyen Y, Nguyen NX, Rogers JL, Liao J, MacMillan JB, Jiang Y, Sperandio V.

MBio. 2015 Mar 31;6(2). pii: e02429-14. doi: 10.1128/mBio.02429-14.

19.

Thiasporines A-C, thiazine and thiazole derivatives from a marine-derived Actinomycetospora chlora.

Fu P, MacMillan JB.

J Nat Prod. 2015 Mar 27;78(3):548-51. doi: 10.1021/np500929z. Epub 2015 Jan 13.

20.

Novel mutations in the DYNC1H1 tail domain refine the genetic and clinical spectrum of dyneinopathies.

Peeters K, Bervoets S, Chamova T, Litvinenko I, De Vriendt E, Bichev S, Kancheva D, Mitev V, Kennerson M, Timmerman V, De Jonghe P, Tournev I, MacMillan J, Jordanova A.

Hum Mutat. 2015 Mar;36(3):287-91. doi: 10.1002/humu.22744.

PMID:
25512093
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