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Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects.

Karunadharma PP, Basisty N, Dai DF, Chiao YA, Quarles EK, Hsieh EJ, Crispin D, Bielas JH, Ericson NG, Beyer RP, MacKay VL, MacCoss MJ, Rabinovitch PS.

Aging Cell. 2015 Aug;14(4):547-57. doi: 10.1111/acel.12317. Epub 2015 Mar 23.


The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1.

O'Leary MN, Schreiber KH, Zhang Y, Duc AC, Rao S, Hale JS, Academia EC, Shah SR, Morton JF, Holstein CA, Martin DB, Kaeberlein M, Ladiges WC, Fink PJ, Mackay VL, Wiest DL, Kennedy BK.

PLoS Genet. 2013;9(8):e1003708. doi: 10.1371/journal.pgen.1003708. Epub 2013 Aug 22.


Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo.

Garelick MG, Mackay VL, Yanagida A, Academia EC, Schreiber KH, Ladiges WC, Kennedy BK.

Cell Cycle. 2013 Aug 1;12(15):2493-504. doi: 10.4161/cc.25512. Epub 2013 Jul 1.


Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

Ramos FJ, Chen SC, Garelick MG, Dai DF, Liao CY, Schreiber KH, MacKay VL, An EH, Strong R, Ladiges WC, Rabinovitch PS, Kaeberlein M, Kennedy BK.

Sci Transl Med. 2012 Jul 25;4(144):144ra103. doi: 10.1126/scitranslmed.3003802.


Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae.

Steffen KK, McCormick MA, Pham KM, MacKay VL, Delaney JR, Murakami CJ, Kaeberlein M, Kennedy BK.

Genetics. 2012 May;191(1):107-18. doi: 10.1534/genetics.111.136549. Epub 2012 Feb 29.


Translate this ... during dietary restriction.

Kennedy BK, Mackay VL.

Cell Metab. 2009 Oct;10(4):247-8. doi: 10.1016/j.cmet.2009.09.004.


Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.

Steffen KK, MacKay VL, Kerr EO, Tsuchiya M, Hu D, Fox LA, Dang N, Johnston ED, Oakes JA, Tchao BN, Pak DN, Fields S, Kennedy BK, Kaeberlein M.

Cell. 2008 Apr 18;133(2):292-302. doi: 10.1016/j.cell.2008.02.037.


The undertranslated transcriptome reveals widespread translational silencing by alternative 5' transcript leaders.

Law GL, Bickel KS, MacKay VL, Morris DR.

Genome Biol. 2005;6(13):R111. Epub 2006 Jan 3.


Gene expression analyzed by high-resolution state array analysis and quantitative proteomics: response of yeast to mating pheromone.

MacKay VL, Li X, Flory MR, Turcott E, Law GL, Serikawa KA, Xu XL, Lee H, Goodlett DR, Aebersold R, Zhao LP, Morris DR.

Mol Cell Proteomics. 2004 May;3(5):478-89. Epub 2004 Feb 6.


The transcriptome and its translation during recovery from cell cycle arrest in Saccharomyces cerevisiae.

Serikawa KA, Xu XL, MacKay VL, Law GL, Zong Q, Zhao LP, Bumgarner R, Morris DR.

Mol Cell Proteomics. 2003 Mar;2(3):191-204. Epub 2003 Apr 7.


A functionally compromised intermediate in extrathymic CD8+ T cell deletion.

Dillon SR, MacKay VL, Fink PJ.

Immunity. 1995 Sep;3(3):321-33.


Clathrin-dependent localization of alpha 1,3 mannosyltransferase to the Golgi complex of Saccharomyces cerevisiae.

Graham TR, Seeger M, Payne GS, MacKay VL, Emr SD.

J Cell Biol. 1994 Nov;127(3):667-78.


Cloning and analysis of the Saccharomyces cerevisiae MNN9 and MNN1 genes required for complex glycosylation of secreted proteins.

Yip CL, Welch SK, Klebl F, Gilbert T, Seidel P, Grant FJ, O'Hara PJ, MacKay VL.

Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2723-7.


Characterization of the Bar proteinase, an extracellular enzyme from the yeast Saccharomyces cerevisiae.

MacKay VL, Armstrong J, Yip C, Welch S, Walker K, Osborn S, Sheppard P, Forstrom J.

Adv Exp Med Biol. 1991;306:161-72. No abstract available.


Superimposition of temperature regulation on yeast promoters.

Sledziewski AZ, Bell A, Yip C, Kelsay K, Grant FJ, MacKay VL.

Methods Enzymol. 1990;185:351-66. No abstract available.


The STE4 and STE18 genes of yeast encode potential beta and gamma subunits of the mating factor receptor-coupled G protein.

Whiteway M, Hougan L, Dignard D, Thomas DY, Bell L, Saari GC, Grant FJ, O'Hara P, MacKay VL.

Cell. 1989 Feb 10;56(3):467-77.


Function of the STE4 and STE18 genes in mating pheromone signal transduction in Saccharomyces cerevisiae.

Whiteway M, Hougan L, Dignard D, Bell L, Saari G, Grant F, O'Hara P, MacKay VL, Thomas DY.

Cold Spring Harb Symp Quant Biol. 1988;53 Pt 2:585-90. No abstract available.


The Saccharomyces cerevisiae BAR1 gene encodes an exported protein with homology to pepsin.

MacKay VL, Welch SK, Insley MY, Manney TR, Holly J, Saari GC, Parker ML.

Proc Natl Acad Sci U S A. 1988 Jan;85(1):55-9.

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