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Items: 1 to 20 of 72

1.

Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense.

Graf FE, Ludin P, Arquint C, Schmidt RS, Schaub N, Kunz Renggli C, Munday JC, Krezdorn J, Baker N, Horn D, Balmer O, Caccone A, de Koning HP, Mäser P.

Cell Mol Life Sci. 2016 Mar 14. [Epub ahead of print]

PMID:
26973180
2.

A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes.

Wenzler T, Schumann Burkard G, Schmidt RS, Mäser P, Bergner A, Roditi I, Brun R.

Sci Rep. 2016 Mar 2;6:22451. doi: 10.1038/srep22451.

3.

Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel).

Jourdan J, Matile H, Reift E, Biehlmaier O, Dong Y, Wang X, Mäser P, Vennerstrom JL, Wittlin S.

ACS Infect Dis. 2016 Jan 8;2(1):54-61. Epub 2015 Sep 28.

4.

Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning.

Kaiser M, Mäser P, Tadoori LP, Ioset JR, Brun R.

PLoS One. 2015 Aug 13;10(8):e0135556. doi: 10.1371/journal.pone.0135556. eCollection 2015.

5.

Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates.

Graf FE, Baker N, Munday JC, de Koning HP, Horn D, Mäser P.

Int J Parasitol Drugs Drug Resist. 2015 May 7;5(2):65-8. doi: 10.1016/j.ijpddr.2015.04.002. eCollection 2015 Aug.

6.

An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei.

de Macêdo JP, Schumann Burkard G, Niemann M, Barrett MP, Vial H, Mäser P, Roditi I, Schneider A, Bütikofer P.

PLoS Pathog. 2015 May 6;11(5):e1004875. doi: 10.1371/journal.ppat.1004875. eCollection 2015 May.

7.

A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes.

Steinmann ME, González-Salgado A, Bütikofer P, Mäser P, Sigel E.

FASEB J. 2015 Aug;29(8):3228-37. doi: 10.1096/fj.15-271353. Epub 2015 Apr 13.

PMID:
25868728
8.

Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities.

Witschel MC, Rottmann M, Schwab A, Leartsakulpanich U, Chitnumsub P, Seet M, Tonazzi S, Schwertz G, Stelzer F, Mietzner T, McNamara C, Thater F, Freymond C, Jaruwat A, Pinthong C, Riangrungroj P, Oufir M, Hamburger M, Mäser P, Sanz-Alonso LM, Charman S, Wittlin S, Yuthavong Y, Chaiyen P, Diederich F.

J Med Chem. 2015 Apr 9;58(7):3117-30. doi: 10.1021/jm501987h. Epub 2015 Mar 18.

PMID:
25785478
9.

Match-making for posaconazole through systems thinking.

Fügi MA, Kaiser M, Tanner M, Schneiter R, Mäser P, Guan XL.

Trends Parasitol. 2015 Feb;31(2):46-51. doi: 10.1016/j.pt.2014.11.004. Epub 2014 Dec 6.

PMID:
25486978
10.

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.

Shameer S, Logan-Klumpler FJ, Vinson F, Cottret L, Merlet B, Achcar F, Boshart M, Berriman M, Breitling R, Bringaud F, Bütikofer P, Cattanach AM, Bannerman-Chukualim B, Creek DJ, Crouch K, de Koning HP, Denise H, Ebikeme C, Fairlamb AH, Ferguson MA, Ginger ML, Hertz-Fowler C, Kerkhoven EJ, Mäser P, Michels PA, Nayak A, Nes DW, Nolan DP, Olsen C, Silva-Franco F, Smith TK, Taylor MC, Tielens AG, Urbaniak MD, van Hellemond JJ, Vincent IM, Wilkinson SR, Wyllie S, Opperdoes FR, Barrett MP, Jourdan F.

Nucleic Acids Res. 2015 Jan;43(Database issue):D637-44. doi: 10.1093/nar/gku944. Epub 2014 Oct 9.

11.

Comparative genomics reveals multiple genetic backgrounds of human pathogenicity in the Trypanosoma brucei complex.

Sistrom M, Evans B, Bjornson R, Gibson W, Balmer O, Mäser P, Aksoy S, Caccone A.

Genome Biol Evol. 2014 Oct 5;6(10):2811-9. doi: 10.1093/gbe/evu222.

12.

Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids.

Mathieu C, González Salgado A, Wirdnam C, Meier S, Grotemeyer MS, Inbar E, Mäser P, Zilberstein D, Sigel E, Bütikofer P, Rentsch D.

Biochem J. 2014 Oct 1;463(1):9-18. doi: 10.1042/BJ20140719.

PMID:
24988048
13.

Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack.

Fügi MA, Gunasekera K, Ochsenreiter T, Guan X, Wenk MR, Mäser P.

J Lipid Res. 2014 May;55(5):929-38. doi: 10.1194/jlr.M048017. Epub 2014 Mar 13.

14.

Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity.

Lüscher A, Lamprea-Burgunder E, Graf FE, de Koning HP, Mäser P.

Int J Parasitol Drugs Drug Resist. 2013 Dec 19;4(1):55-63. doi: 10.1016/j.ijpddr.2013.12.001. eCollection 2014 Apr.

15.

Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors.

Wang T, Bisson WH, Mäser P, Scapozza L, Picard D.

J Med Chem. 2014 Mar 27;57(6):2524-35. doi: 10.1021/jm401801t. Epub 2014 Mar 3.

PMID:
24580531
16.

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.

Munday JC, Eze AA, Baker N, Glover L, Clucas C, Aguinaga Andrés D, Natto MJ, Teka IA, McDonald J, Lee RS, Graf FE, Ludin P, Burchmore RJ, Turner CM, Tait A, MacLeod A, Mäser P, Barrett MP, Horn D, De Koning HP.

J Antimicrob Chemother. 2014 Mar;69(3):651-63. doi: 10.1093/jac/dkt442. Epub 2013 Nov 13.

17.

Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol.

Graf FE, Ludin P, Wenzler T, Kaiser M, Brun R, Pyana PP, Büscher P, de Koning HP, Horn D, Mäser P.

PLoS Negl Trop Dis. 2013 Oct 10;7(10):e2475. doi: 10.1371/journal.pntd.0002475. eCollection 2013.

18.

In silico ionomics segregates parasitic from free-living eukaryotes.

Greganova E, Steinmann M, Mäser P, Fankhauser N.

Genome Biol Evol. 2013;5(10):1902-9. doi: 10.1093/gbe/evt134.

19.

Characterization of choline uptake in Trypanosoma brucei procyclic and bloodstream forms.

Macêdo JP, Schmidt RS, Mäser P, Rentsch D, Vial HJ, Sigel E, Bütikofer P.

Mol Biochem Parasitol. 2013 Jul;190(1):16-22. doi: 10.1016/j.molbiopara.2013.05.007. Epub 2013 Jun 6.

PMID:
23747277
20.

Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story.

Baker N, de Koning HP, Mäser P, Horn D.

Trends Parasitol. 2013 Mar;29(3):110-8. doi: 10.1016/j.pt.2012.12.005. Epub 2013 Jan 30. Review.

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