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Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease.

Allen GI, Amoroso N, Anghel C, Balagurusamy V, Bare CJ, Beaton D, Bellotti R, Bennett DA, Boehme K, Boutros PC, Caberlotto L, Caloian C, Campbell F, Neto EC, Chang YC, Chen B, Chen CY, Chien TY, Clark T, Das S, Davatzikos C, Deng J, Dillenberger D, Dobson RJ, Dong Q, Doshi J, Duma D, Errico R, Erus G, Everett E, Fardo DW, Friend SH, Fröhlich H, Gan J, St George-Hyslop P, Ghosh SS, Glaab E, Green RC, Guan Y, Hong MY, Huang C, Hwang J, Ibrahim J, Inglese P, Jiang Q, Katsumata Y, Kauwe JS, Klein A, Kong D, Krause R, Lalonde E, Lauria M, Lee E, Lin X, Liu Z, Livingstone J, Logsdon BA, Lovestone S, Lyappan A, Ma M, Malhotra A, Mangravite LM, Maxwell TJ, Merrill E, Nagorski J, Namasivayam A, Narayan M, Naz M, Newhouse SJ, Norman TC, Nurtdinov RN, Oyang YJ, Pawitan Y, Peng S, Peters MA, Piccolo SR, Praveen P, Priami C, Sabelnykova VY, Senger P, Shen X, Simmons A, Sotiras A, Stolovitzky G, Tangaro S, Tateo A, Tung YA, Tustison NJ, Varol E, Vradenburg G, Weiner MW, Xiao G, Xie L, Xie Y, Xu J, Yang H, Zhan X, Zhou Y, Zhu F, Zhu H, Zhu S; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2016 Apr 11. pii: S1552-5260(16)00081-9. doi: 10.1016/j.jalz.2016.02.006. [Epub ahead of print]


Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly.

Westwood S, Leoni E, Hye A, Lynham S, Khondoker MR, Ashton NJ, Kiddle SJ, Baird AL, Sainz-Fuertes R, Leung R, Graf J, Hehir CT, Baker D, Cereda C, Bazenet C, Ward M, Thambisetty M, Lovestone S.

J Alzheimers Dis. 2016 Mar 29. [Epub ahead of print]


Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges.

O'Bryant SE, Lista S, Rissman RA, Edwards M, Zhang F, Hall J, Zetterberg H, Lovestone S, Gupta V, Graff-Radford N, Martins R, Jeromin A, Waring S, Oh E, King M, Baker L, Hampel H.

Alzheimers Dement (Amst). 2016;3:27-34.


The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume.

Lupton MK, Strike L, Hansell NK, Wen W, Mather KA, Armstrong NJ, Thalamuthu A, McMahon KL, de Zubicaray GI, Assareh AA, Simmons A, Proitsi P, Powell JF, Montgomery GW, Hibar DP, Westman E, Tsolaki M, Kloszewska I, Soininen H, Mecocci P, Velas B, Lovestone S; Alzheimer's Disease Neuroimaging Initiative, Brodaty H, Ames D, Trollor JN, Martin NG, Thompson PM, Sachdev PS, Wright MJ.

Neurobiol Aging. 2016 Apr;40:68-77. doi: 10.1016/j.neurobiolaging.2015.12.023. Epub 2016 Jan 11.


Are premorbid abnormal personality traits associated with behavioural and psychological symptoms in dementia?

Prior J, Abraham R, Nicholas H, Chan T, Vanvlymen J, Lovestone S, Boothby H.

Int J Geriatr Psychiatry. 2016 Mar 10. doi: 10.1002/gps.4418. [Epub ahead of print]


Correction to "Glycosylation of Human Plasma Clusterin Yields a Novel Candidate Biomarker of Alzheimer's Disease".

Liang HC, Russell C, Mitra V, Chung R, Hye A, Bazenet C, Lovestone S, Pike I, Ward M.

J Proteome Res. 2016 Mar 4;15(3):1114. doi: 10.1021/acs.jproteome.6b00080. Epub 2016 Feb 1. No abstract available.


Blood metabolite markers of neocortical amyloid-β burden: discovery and enrichment using candidate proteins.

Voyle N, Kim M, Proitsi P, Ashton NJ, Baird AL, Bazenet C, Hye A, Westwood S, Chung R, Ward M, Rabinovici GD, Lovestone S, Breen G, Legido-Quigley C, Dobson RJ, Kiddle SJ; Alzheimer's Disease Neuroimaging Initiative.

Transl Psychiatry. 2016 Jan 26;6:e719. doi: 10.1038/tp.2015.205.


Measuring Global Brain Atrophy with the Brain Volume/Cerebrospinal Fluid Index: Normative Values, Cut-Offs and Clinical Associations.

Orellana C, Ferreira D, Muehlboeck JS, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Soininen H, Lovestone S, Simmons A, Wahlund LO, Westman E; AddNeuronMed consortium and for the Alzheimer''s Disease Neuroimaging Initiative.

Neurodegener Dis. 2016;16(1-2):77-86. doi: 10.1159/000442443. Epub 2015 Dec 19.


Development of interventions for the secondary prevention of Alzheimer's dementia: the European Prevention of Alzheimer's Dementia (EPAD) project.

Ritchie CW, Molinuevo JL, Truyen L, Satlin A, Van der Geyten S, Lovestone S; European Prevention of Alzheimer's Dementia (EPAD) Consortium.

Lancet Psychiatry. 2016 Feb;3(2):179-86. doi: 10.1016/S2215-0366(15)00454-X. Epub 2015 Dec 10. Review.


Blood-Based Proteomic Biomarkers of Alzheimer's Disease Pathology.

Baird AL, Westwood S, Lovestone S.

Front Neurol. 2015 Nov 16;6:236. doi: 10.3389/fneur.2015.00236. eCollection 2015. Review.


Longitudinal Protein Changes in Blood Plasma Associated with the Rate of Cognitive Decline in Alzheimer's Disease.

Sattlecker M, Khondoker M, Proitsi P, Williams S, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Dobson RJ.

J Alzheimers Dis. 2015 Nov 23;49(4):1105-14. doi: 10.3233/JAD-140669.


Quantitative validation of a visual rating scale for frontal atrophy: associations with clinical status, APOE e4, CSF biomarkers and cognition.

Ferreira D, Cavallin L, Granberg T, Lindberg O, Aguilar C, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Soininen H, Lovestone S, Simmons A, Wahlund LO, Westman E; AddNeuroMed consortium and for the Alzheimer’s Disease Neuroimaging Initiative*.

Eur Radiol. 2015 Nov 11. [Epub ahead of print]


Glycosylation of Human Plasma Clusterin Yields a Novel Candidate Biomarker of Alzheimer's Disease.

Liang HC, Russell C, Mitra V, Chung R, Hye A, Bazenet C, Lovestone S, Pike I, Ward M.

J Proteome Res. 2015 Dec 4;14(12):5063-76. doi: 10.1021/acs.jproteome.5b00892. Epub 2015 Nov 4.


A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis.

Voyle N, Keohane A, Newhouse S, Lunnon K, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Hodges A, Kiddle S, Dobson RJ.

J Alzheimers Dis. 2015 Oct 15;49(3):659-69. doi: 10.3233/JAD-150440.


The Effect of Age Correction on Multivariate Classification in Alzheimer's Disease, with a Focus on the Characteristics of Incorrectly and Correctly Classified Subjects.

Falahati F, Ferreira D, Soininen H, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Lovestone S, Eriksdotter M, Wahlund LO, Simmons A, Westman E; AddNeuroMed consortium and the Alzheimer’s Disease Neuroimaging Initiative.

Brain Topogr. 2016 Mar;29(2):296-307. doi: 10.1007/s10548-015-0455-1. Epub 2015 Oct 6.


Precompetitive Data Sharing as a Catalyst to Address Unmet Needs in Parkinson's Disease.

Stephenson D, Hu MT, Romero K, Breen K, Burn D, Ben-Shlomo Y, Bhattaram A, Isaac M, Venuto C, Kubota K, Little MA, Friend S, Lovestone S, Morris HR, Grosset D, Sutherland M, Gallacher J, Williams-Gray C, Bain LJ, Avilés E, Marek K, Toga AW, Stark Y, Forrest Gordon M, Ford S.

J Parkinsons Dis. 2015;5(3):581-94. doi: 10.3233/JPD-150570.


Tract Based Spatial Statistic Reveals No Differences in White Matter Microstructural Organization between Carriers and Non-Carriers of the APOE ɛ4 and ɛ2 Alleles in Young Healthy Adolescents.

Dell'Acqua F, Khan W, Gottlieb N, Giampietro V, Ginestet C, Bouls D, Newhouse S, Dobson R, Banaschewski T, Barker GJ, Bokde AL, Büchel C, Conrod P, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Lemaítre H, Nees F, Paus T, Pausova Z, Rietschel M, Smolka MN, Ströhle A, Gallinat J, Westman E, Schumann G, Lovestone S, Simmons A; IMAGEN consortium (

J Alzheimers Dis. 2015;47(4):977-84. doi: 10.3233/JAD-140519.


No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease.

Chiam JT, Lunnon K, Voyle N, Proitsi P, Coppola G, Geschwind D, Nelson S, Johnston C, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Hodges A, Lovestone S, Newhouse S, Dobson RJ, Kiddle SJ, Sattlecker M.

J Alzheimers Dis. 2015;47(3):741-50. doi: 10.3233/JAD-150289.


A Subset of Cerebrospinal Fluid Proteins from a Multi-Analyte Panel Associated with Brain Atrophy, Disease Classification and Prediction in Alzheimer's Disease.

Khan W, Aguilar C, Kiddle SJ, Doyle O, Thambisetty M, Muehlboeck S, Sattlecker M, Newhouse S, Lovestone S, Dobson R, Giampietro V, Westman E, Simmons A; Alzheimer’s Disease Neuroimaging Initiative.

PLoS One. 2015 Aug 18;10(8):e0134368. doi: 10.1371/journal.pone.0134368. eCollection 2015.


Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions.

Andrieu S, Coley N, Lovestone S, Aisen PS, Vellas B.

Lancet Neurol. 2015 Sep;14(9):926-44. doi: 10.1016/S1474-4422(15)00153-2. Epub 2015 Jul 23. Review.

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