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Items: 1 to 20 of 96

1.

Altered oncomodules underlie chromatin regulatory factors driver mutations.

Frigola J, Iturbide A, Lopez-Bigas N, Peiro S, Gonzalez-Perez A.

Oncotarget. 2016 Apr 15. doi: 10.18632/oncotarget.8752. [Epub ahead of print]

2.

Nucleotide excision repair is impaired by binding of transcription factors to DNA.

Sabarinathan R, Mularoni L, Deu-Pons J, Gonzalez-Perez A, López-Bigas N.

Nature. 2016 Apr 14;532(7598):264-7. doi: 10.1038/nature17661.

PMID:
27075101
3.

Corrigendum: Notch signal strength controls cell fate in the haemogenic endothelium.

Gama-Norton L, Ferrando E, Ruiz-Herguido C, Liu Z, Guiu J, Islam AB, Lee SU, Yan M, Guidos CJ, López-Bigas N, Maeda T, Espinosa L, Kopan R, Bigas A.

Nat Commun. 2016 Mar 4;7:10978. doi: 10.1038/ncomms10978. No abstract available.

4.

Notch signal strength controls cell fate in the haemogenic endothelium.

Gama-Norton L, Ferrando E, Ruiz-Herguido C, Liu Z, Guiu J, Islam AB, Lee SU, Yan M, Guidos CJ, López-Bigas N, Maeda T, Espinosa L, Kopan R, Bigas A.

Nat Commun. 2015 Oct 14;6:8510. doi: 10.1038/ncomms9510.

5.

Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells.

Váraljai R, Islam AB, Beshiri ML, Rehman J, Lopez-Bigas N, Benevolenskaya EV.

Genes Dev. 2015 Sep 1;29(17):1817-34. doi: 10.1101/gad.264036.115. Epub 2015 Aug 27.

6.

Non-coding recurrent mutations in chronic lymphocytic leukaemia.

Puente XS, Beà S, Valdés-Mas R, Villamor N, Gutiérrez-Abril J, Martín-Subero JI, Munar M, Rubio-Pérez C, Jares P, Aymerich M, Baumann T, Beekman R, Belver L, Carrio A, Castellano G, Clot G, Colado E, Colomer D, Costa D, Delgado J, Enjuanes A, Estivill X, Ferrando AA, Gelpí JL, González B, González S, González M, Gut M, Hernández-Rivas JM, López-Guerra M, Martín-García D, Navarro A, Nicolás P, Orozco M, Payer ÁR, Pinyol M, Pisano DG, Puente DA, Queirós AC, Quesada V, Romeo-Casabona CM, Royo C, Royo R, Rozman M, Russiñol N, Salaverría I, Stamatopoulos K, Stunnenberg HG, Tamborero D, Terol MJ, Valencia A, López-Bigas N, Torrents D, Gut I, López-Guillermo A, López-Otín C, Campo E.

Nature. 2015 Oct 22;526(7574):519-24. doi: 10.1038/nature14666. Epub 2015 Jul 22.

PMID:
26200345
7.

Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance.

Gallardo F, Padrón A, Garcia-Carbonell R, Rius C, González-Perez A, Arumí-Uria M, Iglesias M, Nonell L, Bellosillo B, Segura S, Pujol RM, Lopez-Bigas N, Bertran J, Bigas A, Espinosa L.

Oncotarget. 2015 Apr 20;6(11):9284-94.

8.

In silico prescription of anticancer drugs to cohorts of 28 tumor types reveals targeting opportunities.

Rubio-Perez C, Tamborero D, Schroeder MP, Antolín AA, Deu-Pons J, Perez-Llamas C, Mestres J, Gonzalez-Perez A, Lopez-Bigas N.

Cancer Cell. 2015 Mar 9;27(3):382-96. doi: 10.1016/j.ccell.2015.02.007.

9.

The transcriptional repressor HDAC7 promotes apoptosis and c-Myc downregulation in particular types of leukemia and lymphoma.

Barneda-Zahonero B, Collazo O, Azagra A, Fernández-Duran I, Serra-Musach J, Islam AB, Vega-García N, Malatesta R, Camós M, Gómez A, Román-González L, Vidal A, López-Bigas N, Villanueva A, Esteller M, Parra M.

Cell Death Dis. 2015 Feb 12;6:e1635. doi: 10.1038/cddis.2014.594.

10.

Chromatin-wide profiling of DYRK1A reveals a role as a gene-specific RNA polymerase II CTD kinase.

Di Vona C, Bezdan D, Islam AB, Salichs E, López-Bigas N, Ossowski S, de la Luna S.

Mol Cell. 2015 Feb 5;57(3):506-20. doi: 10.1016/j.molcel.2014.12.026. Epub 2015 Jan 22.

11.

Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes.

Leiserson MD, Vandin F, Wu HT, Dobson JR, Eldridge JV, Thomas JL, Papoutsaki A, Kim Y, Niu B, McLellan M, Lawrence MS, Gonzalez-Perez A, Tamborero D, Cheng Y, Ryslik GA, Lopez-Bigas N, Getz G, Ding L, Raphael BJ.

Nat Genet. 2015 Feb;47(2):106-14. doi: 10.1038/ng.3168. Epub 2014 Dec 15.

12.

Independent component analysis uncovers the landscape of the bladder tumor transcriptome and reveals insights into luminal and basal subtypes.

Biton A, Bernard-Pierrot I, Lou Y, Krucker C, Chapeaublanc E, Rubio-Pérez C, López-Bigas N, Kamoun A, Neuzillet Y, Gestraud P, Grieco L, Rebouissou S, de Reyniès A, Benhamou S, Lebret T, Southgate J, Barillot E, Allory Y, Zinovyev A, Radvanyi F.

Cell Rep. 2014 Nov 20;9(4):1235-45. doi: 10.1016/j.celrep.2014.10.035. Epub 2014 Nov 13.

13.

Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence.

Guiu J, Bergen DJ, De Pater E, Islam AB, Ayllón V, Gama-Norton L, Ruiz-Herguido C, González J, López-Bigas N, Menendez P, Dzierzak E, Espinosa L, Bigas A.

J Exp Med. 2014 Nov 17;211(12):2411-23. doi: 10.1084/jem.20131857. Epub 2014 Nov 10.

14.

NF-κB directly mediates epigenetic deregulation of common microRNAs in Epstein-Barr virus-mediated transformation of B-cells and in lymphomas.

Vento-Tormo R, Rodríguez-Ubreva J, Lisio LD, Islam AB, Urquiza JM, Hernando H, López-Bigas N, Shannon-Lowe C, Martínez N, Montes-Moreno S, Piris MA, Ballestar E.

Nucleic Acids Res. 2014;42(17):11025-39. doi: 10.1093/nar/gku826. Epub 2014 Sep 8.

15.

Fast randomization of large genomic datasets while preserving alteration counts.

Gobbi A, Iorio F, Dawson KJ, Wedge DC, Tamborero D, Alexandrov LB, Lopez-Bigas N, Garnett MJ, Jurman G, Saez-Rodriguez J.

Bioinformatics. 2014 Sep 1;30(17):i617-23. doi: 10.1093/bioinformatics/btu474.

16.

OncodriveROLE classifies cancer driver genes in loss of function and activating mode of action.

Schroeder MP, Rubio-Perez C, Tamborero D, Gonzalez-Perez A, Lopez-Bigas N.

Bioinformatics. 2014 Sep 1;30(17):i549-55. doi: 10.1093/bioinformatics/btu467.

17.

Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin.

Hoadley KA, Yau C, Wolf DM, Cherniack AD, Tamborero D, Ng S, Leiserson MD, Niu B, McLellan MD, Uzunangelov V, Zhang J, Kandoth C, Akbani R, Shen H, Omberg L, Chu A, Margolin AA, Van't Veer LJ, Lopez-Bigas N, Laird PW, Raphael BJ, Ding L, Robertson AG, Byers LA, Mills GB, Weinstein JN, Van Waes C, Chen Z, Collisson EA; Cancer Genome Atlas Research Network, Benz CC, Perou CM, Stuart JM.

Cell. 2014 Aug 14;158(4):929-44. doi: 10.1016/j.cell.2014.06.049. Epub 2014 Aug 7.

18.

An intronic microRNA links Rb/E2F and EGFR signaling.

Truscott M, Islam AB, Lightfoot J, López-Bigas N, Frolov MV.

PLoS Genet. 2014 Jul 24;10(7):e1004493. doi: 10.1371/journal.pgen.1004493. eCollection 2014 Jul.

19.

Regulation of plant stem cell quiescence by a brassinosteroid signaling module.

Vilarrasa-Blasi J, González-García MP, Frigola D, Fàbregas N, Alexiou KG, López-Bigas N, Rivas S, Jauneau A, Lohmann JU, Benfey PN, Ibañes M, Caño-Delgado AI.

Dev Cell. 2014 Jul 14;30(1):36-47. doi: 10.1016/j.devcel.2014.05.020. Epub 2014 Jun 26. Erratum in: Dev Cell. 2015 Apr 20;33(2):238.

20.

jHeatmap: an interactive heatmap viewer for the web.

Deu-Pons J, Schroeder MP, Lopez-Bigas N.

Bioinformatics. 2014 Jun 15;30(12):1757-8. doi: 10.1093/bioinformatics/btu094. Epub 2014 Feb 23.

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