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Items: 19


Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders.

van Schouwenburg PA, Davenport EE, Kienzler AK, Marwah I, Wright B, Lucas M, Malinauskas T, Martin HC; WGS500 Consortium, Lockstone HE, Cazier JB, Chapel HM, Knight JC, Patel SY.

Clin Immunol. 2015 Oct;160(2):301-14. doi: 10.1016/j.clim.2015.05.020. Epub 2015 Jun 26.


Nutrigenomics of high fat diet induced obesity in mice suggests relationships between susceptibility to fatty liver disease and the proteasome.

Waller-Evans H, Hue C, Fearnside J, Rothwell AR, Lockstone HE, Caldérari S, Wilder SP, Cazier JB, Scott J, Gauguier D.

PLoS One. 2013 Dec 6;8(12):e82825. doi: 10.1371/journal.pone.0082825. eCollection 2013.


DOCK8 is critical for the survival and function of NKT cells.

Crawford G, Enders A, Gileadi U, Stankovic S, Zhang Q, Lambe T, Crockford TL, Lockstone HE, Freeman A, Arkwright PD, Smart JM, Ma CS, Tangye SG, Goodnow CC, Cerundolo V, Godfrey DI, Su HC, Randall KL, Cornall RJ.

Blood. 2013 Sep 19;122(12):2052-61. doi: 10.1182/blood-2013-02-482331. Epub 2013 Aug 8.


Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain.

Vernes SC, Oliver PL, Spiteri E, Lockstone HE, Puliyadi R, Taylor JM, Ho J, Mombereau C, Brewer A, Lowy E, Nicod J, Groszer M, Baban D, Sahgal N, Cazier JB, Ragoussis J, Davies KE, Geschwind DH, Fisher SE.

PLoS Genet. 2011 Jul;7(7):e1002145. doi: 10.1371/journal.pgen.1002145. Epub 2011 Jul 7.


Pervasive haplotypic variation in the spliceo-transcriptome of the human major histocompatibility complex.

Vandiedonck C, Taylor MS, Lockstone HE, Plant K, Taylor JM, Durrant C, Broxholme J, Fairfax BP, Knight JC.

Genome Res. 2011 Jul;21(7):1042-54. doi: 10.1101/gr.116681.110. Epub 2011 May 31.


Exon array data analysis using Affymetrix power tools and R statistical software.

Lockstone HE.

Brief Bioinform. 2011 Nov;12(6):634-44. doi: 10.1093/bib/bbq086. Epub 2011 Apr 15.


Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes.

Herrera BM, Lockstone HE, Taylor JM, Ria M, Barrett A, Collins S, Kaisaki P, Argoud K, Fernandez C, Travers ME, Grew JP, Randall JC, Gloyn AL, Gauguier D, McCarthy MI, Lindgren CM.

Diabetologia. 2010 Jun;53(6):1099-109. doi: 10.1007/s00125-010-1667-2. Epub 2010 Mar 3.


Gene set analysis of lung samples provides insight into pathogenesis of progressive, fibrotic pulmonary sarcoidosis.

Lockstone HE, Sanderson S, Kulakova N, Baban D, Leonard A, Kok WL, McGowan S, McMichael AJ, Ho LP.

Am J Respir Crit Care Med. 2010 Jun 15;181(12):1367-75. doi: 10.1164/rccm.200912-1855OC. Epub 2010 Mar 1.


Variability of gene expression profiles in human blood and lymphoblastoid cell lines.

Min JL, Barrett A, Watts T, Pettersson FH, Lockstone HE, Lindgren CM, Taylor JM, Allen M, Zondervan KT, McCarthy MI.

BMC Genomics. 2010 Feb 8;11:96. doi: 10.1186/1471-2164-11-96.


Expression profiling of fibroblasts identifies cell cycle abnormalities in schizophrenia.

Wang L, Lockstone HE, Guest PC, Levin Y, Palotás A, Pietsch S, Schwarz E, Rahmoune H, Harris LW, Ma D, Bahn S.

J Proteome Res. 2010 Jan;9(1):521-7. doi: 10.1021/pr900867x.


MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes.

Herrera BM, Lockstone HE, Taylor JM, Wills QF, Kaisaki PJ, Barrett A, Camps C, Fernandez C, Ragoussis J, Gauguier D, McCarthy MI, Lindgren CM.

BMC Med Genomics. 2009 Aug 18;2:54. doi: 10.1186/1755-8794-2-54.


Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia.

Harris LW, Lockstone HE, Khaitovich P, Weickert CS, Webster MJ, Bahn S.

BMC Med Genomics. 2009 May 20;2:28. doi: 10.1186/1755-8794-2-28.


Antipsychotic treatment alters protein expression associated with presynaptic function and nervous system development in rat frontal cortex.

Ma D, Chan MK, Lockstone HE, Pietsch SR, Jones DN, Cilia J, Hill MD, Robbins MJ, Benzel IM, Umrania Y, Guest PC, Levin Y, Maycox PR, Bahn S.

J Proteome Res. 2009 Jul;8(7):3284-97. doi: 10.1021/pr800983p.


Metabolic changes in schizophrenia and human brain evolution.

Khaitovich P, Lockstone HE, Wayland MT, Tsang TM, Jayatilaka SD, Guo AJ, Zhou J, Somel M, Harris LW, Holmes E, Pääbo S, Bahn S.

Genome Biol. 2008;9(8):R124. doi: 10.1186/gb-2008-9-8-r124. Epub 2008 Aug 5.


Gene expression profiling in the adult Down syndrome brain.

Lockstone HE, Harris LW, Swatton JE, Wayland MT, Holland AJ, Bahn S.

Genomics. 2007 Dec;90(6):647-60. Epub 2007 Oct 22.


Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues.

Huang JT, Wang L, Prabakaran S, Wengenroth M, Lockstone HE, Koethe D, Gerth CW, Gross S, Schreiber D, Lilley K, Wayland M, Oxley D, Leweke FM, Bahn S.

Mol Psychiatry. 2008 Dec;13(12):1118-28. Epub 2007 Oct 16.


Altered T-cell function in schizophrenia: a cellular model to investigate molecular disease mechanisms.

Craddock RM, Lockstone HE, Rider DA, Wayland MT, Harris LJ, McKenna PJ, Bahn S.

PLoS One. 2007 Aug 1;2(8):e692.


2-D DIGE analysis of liver and red blood cells provides further evidence for oxidative stress in schizophrenia.

Prabakaran S, Wengenroth M, Lockstone HE, Lilley K, Leweke FM, Bahn S.

J Proteome Res. 2007 Jan;6(1):141-9.


Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes.

Ryan MM, Lockstone HE, Huffaker SJ, Wayland MT, Webster MJ, Bahn S.

Mol Psychiatry. 2006 Oct;11(10):965-78. Epub 2006 Aug 8.

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