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Results: 1 to 20 of 43

1.

Heterogeneity of glycolysis in cancers and therapeutic opportunities.

Warmoes MO, Locasale JW.

Biochem Pharmacol. 2014 Aug 2. pii: S0006-2952(14)00425-0. doi: 10.1016/j.bcp.2014.07.019. [Epub ahead of print] Review.

PMID:
25093285
[PubMed - as supplied by publisher]
2.

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.

Shestov AA, Liu X, Ser Z, Cluntun AA, Hung YP, Huang L, Kim D, Le A, Yellen G, Albeck JG, Locasale JW.

Elife. 2014 Jul 9:e03342. doi: 10.7554/eLife.03342. [Epub ahead of print]

PMID:
25009227
[PubMed - as supplied by publisher]
Free PMC Article
3.

A strategy for sensitive, large scale quantitative metabolomics.

Liu X, Ser Z, Cluntun AA, Mentch SJ, Locasale JW.

J Vis Exp. 2014 May 27;(87). doi: 10.3791/51358.

PMID:
24894601
[PubMed - in process]
Free PMC Article
4.

A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis.

Dasgupta T, Croll DH, Owen JA, Vander Heiden MG, Locasale JW, Alon U, Cantley LC, Gunawardena J.

J Biol Chem. 2014 May 9;289(19):13010-25. doi: 10.1074/jbc.M113.546515. Epub 2014 Mar 14.

PMID:
24634222
[PubMed - indexed for MEDLINE]
5.

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival.

Sun S, Shi G, Han X, Francisco AB, Ji Y, Mendonça N, Liu X, Locasale JW, Simpson KW, Duhamel GE, Kersten S, Yates JR 3rd, Long Q, Qi L.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):E582-91. doi: 10.1073/pnas.1318114111. Epub 2014 Jan 22. Erratum in: Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6115.

PMID:
24453213
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Development and quantitative evaluation of a high-resolution metabolomics technology.

Liu X, Ser Z, Locasale JW.

Anal Chem. 2014 Feb 18;86(4):2175-84. doi: 10.1021/ac403845u. Epub 2014 Jan 28.

PMID:
24410464
[PubMed - indexed for MEDLINE]
7.

Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.

Parkhitko AA, Priolo C, Coloff JL, Yun J, Wu JJ, Mizumura K, Xu W, Malinowska IA, Yu J, Kwiatkowski DJ, Locasale JW, Asara JM, Choi AM, Finkel T, Henske EP.

Mol Cancer Res. 2014 Jan;12(1):48-57. doi: 10.1158/1541-7786.MCR-13-0258-T. Epub 2013 Dec 2.

PMID:
24296756
[PubMed - in process]
8.

Epigenetics and cancer metabolism.

Johnson C, Warmoes MO, Shen X, Locasale JW.

Cancer Lett. 2013 Oct 11. pii: S0304-3835(13)00715-5. doi: 10.1016/j.canlet.2013.09.043. [Epub ahead of print]

PMID:
24125862
[PubMed - as supplied by publisher]
9.

Computational approaches for understanding energy metabolism.

Shestov AA, Barker B, Gu Z, Locasale JW.

Wiley Interdiscip Rev Syst Biol Med. 2013 Nov-Dec;5(6):733-50. doi: 10.1002/wsbm.1238. Epub 2013 Jul 29.

PMID:
23897661
[PubMed - in process]
10.

Serine, glycine and one-carbon units: cancer metabolism in full circle.

Locasale JW.

Nat Rev Cancer. 2013 Aug;13(8):572-83. doi: 10.1038/nrc3557. Epub 2013 Jul 4. Review.

PMID:
23822983
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Heterogeneity of tumor-induced gene expression changes in the human metabolic network.

Hu J, Locasale JW, Bielas JH, O'Sullivan J, Sheahan K, Cantley LC, Vander Heiden MG, Vitkup D.

Nat Biotechnol. 2013 Jun;31(6):522-9. doi: 10.1038/nbt.2530. Epub 2013 Apr 21.

PMID:
23604282
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.

Baker R, Lewis SM, Sasaki AT, Wilkerson EM, Locasale JW, Cantley LC, Kuhlman B, Dohlman HG, Campbell SL.

Nat Struct Mol Biol. 2013 Jan;20(1):46-52. doi: 10.1038/nsmb.2430. Epub 2012 Nov 25.

PMID:
23178454
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Interactions between epigenetics and metabolism in cancers.

Yun J, Johnson JL, Hanigan CL, Locasale JW.

Front Oncol. 2012 Nov 15;2:163. doi: 10.3389/fonc.2012.00163. eCollection 2012.

PMID:
23162793
[PubMed]
Free PMC Article
14.

Influence of threonine metabolism on S-adenosylmethionine and histone methylation.

Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H, Asara JM, Daley GQ, Cantley LC.

Science. 2013 Jan 11;339(6116):222-6. doi: 10.1126/science.1226603. Epub 2012 Nov 1.

PMID:
23118012
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The consequences of enhanced cell-autonomous glucose metabolism.

Locasale JW.

Trends Endocrinol Metab. 2012 Nov;23(11):545-51. doi: 10.1016/j.tem.2012.07.005. Epub 2012 Aug 21.

PMID:
22920571
[PubMed - indexed for MEDLINE]
16.

Metabolic rewiring drives resistance to targeted cancer therapy.

Locasale JW.

Mol Syst Biol. 2012 Jul 17;8:597. doi: 10.1038/msb.2012.30. No abstract available.

PMID:
22806144
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, DePinho RA.

Cell. 2012 Apr 27;149(3):656-70. doi: 10.1016/j.cell.2012.01.058.

PMID:
22541435
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Metabolic pathway alterations that support cell proliferation.

Vander Heiden MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM, Locasale JW.

Cold Spring Harb Symp Quant Biol. 2011;76:325-34. doi: 10.1101/sqb.2012.76.010900. Epub 2012 Jan 19. Review.

PMID:
22262476
[PubMed - indexed for MEDLINE]
19.

Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma.

Locasale JW, Melman T, Song S, Yang X, Swanson KD, Cantley LC, Wong ET, Asara JM.

Mol Cell Proteomics. 2012 Jun;11(6):M111.014688. doi: 10.1074/mcp.M111.014688. Epub 2012 Jan 12.

PMID:
22240505
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Human pluripotent stem cells decouple respiration from energy production.

Shyh-Chang N, Zheng Y, Locasale JW, Cantley LC.

EMBO J. 2011 Dec 14;30(24):4851-2. doi: 10.1038/emboj.2011.436. No abstract available.

PMID:
22166995
[PubMed - indexed for MEDLINE]
Free PMC Article

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