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Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice.

Stout MB, Swindell WR, Zhi X, Rohde K, List EO, Berryman DE, Kopchick JJ, Gesing A, Fang Y, Masternak MM.

Oncotarget. 2015 Sep 29;6(29):26702-15. doi: 10.18632/oncotarget.5760.


Growth Hormone Receptor Antagonist Transgenic Mice Have Increased Subcutaneous Adipose Tissue Mass, Altered Glucose Homeostasis and No Change in White Adipose Tissue Cellular Senescence.

Comisford R, Lubbers ER, Householder LA, Suer O, Tchkonia T, Kirkland JL, List EO, Kopchick JJ, Berryman DE.

Gerontology. 2015 Sep 16. [Epub ahead of print]


Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice.

Sadagurski M, Landeryou T, Cady G, Kopchick JJ, List EO, Berryman DE, Bartke A, Miller RA.

Aging Cell. 2015 Aug 12. doi: 10.1111/acel.12382. [Epub ahead of print]


Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice.

List EO, Berryman DE, Ikeno Y, Hubbard GB, Funk K, Comisford R, Young JA, Stout MB, Tchkonia T, Masternak MM, Bartke A, Kirkland JL, Miller RA, Kopchick JJ.

Aging (Albany NY). 2015 Jul;7(7):500-12.


Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice.

Cordoba-Chacon J, Majumdar N, List EO, Diaz-Ruiz A, Frank SJ, Manzano A, Bartrons R, Puchowicz M, Kopchick JJ, Kineman RD.

Diabetes. 2015 Sep;64(9):3093-103. doi: 10.2337/db15-0370. Epub 2015 May 26.


GH action influences adipogenesis of mouse adipose tissue-derived mesenchymal stem cells.

Olarescu NC, Berryman DE, Householder LA, Lubbers ER, List EO, Benencia F, Kopchick JJ, Bollerslev J.

J Endocrinol. 2015 Jul;226(1):13-23. doi: 10.1530/JOE-15-0012. Epub 2015 May 5.


Glucose and Fat Metabolism in Acromegaly: From Mice Models to Patient Care.

Dal J, List EO, Jørgensen JO, Berryman DE.

Neuroendocrinology. 2015 Apr 29. [Epub ahead of print]


Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver.

Zawada I, Masternak MM, List EO, Stout MB, Berryman DE, Lewinski A, Kopchick JJ, Bartke A, Karbownik-Lewinska M, Gesing A.

Aging (Albany NY). 2015 Mar;7(3):195-204.


Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength.

Lim SV, Marenzana M, Hopkinson M, List EO, Kopchick JJ, Pereira M, Javaheri B, Roux JP, Chavassieux P, Korbonits M, Chenu C.

Endocrinology. 2015 Apr;156(4):1362-71. doi: 10.1210/en.2014-1572. Epub 2015 Feb 3.


Male bovine GH transgenic mice have decreased adiposity with an adipose depot-specific increase in immune cell populations.

Benencia F, Harshman S, Duran-Ortiz S, Lubbers ER, List EO, Householder L, Al-Naeeli M, Liang X, Welch L, Kopchick JJ, Berryman DE.

Endocrinology. 2015 May;156(5):1794-803. doi: 10.1210/en.2014-1794. Epub 2014 Dec 18.


Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice.

Dominick G, Berryman DE, List EO, Kopchick JJ, Li X, Miller RA, Garcia GG.

Endocrinology. 2015 Feb;156(2):565-75. doi: 10.1210/en.2014-1690. Epub 2014 Dec 2.


Growth hormone receptor antagonist transgenic mice are protected from hyperinsulinemia and glucose intolerance despite obesity when placed on a HF diet.

Yang T, Householder LA, Lubbers ER, List EO, Troike K, Vesel C, Duran-Ortiz S, Kopchick JJ, Berryman DE.

Endocrinology. 2015 Feb;156(2):555-64. doi: 10.1210/en.2014-1617. Epub 2014 Nov 18.


The absence of GH signaling affects the susceptibility to high-fat diet-induced hypothalamic inflammation in male mice.

Baquedano E, Ruiz-Lopez AM, Sustarsic EG, Herpy J, List EO, Chowen JA, Frago LM, Kopchick JJ, Argente J.

Endocrinology. 2014 Dec;155(12):4856-67. doi: 10.1210/en.2014-1367. Epub 2014 Sep 19.


Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.

Stout MB, Tchkonia T, Pirtskhalava T, Palmer AK, List EO, Berryman DE, Lubbers ER, Escande C, Spong A, Masternak MM, Oberg AL, LeBrasseur NK, Miller RA, Kopchick JJ, Bartke A, Kirkland JL.

Aging (Albany NY). 2014 Jul;6(7):575-86.


Expression of apoptosis-related genes in liver-specific growth hormone receptor gene-disrupted mice is sex dependent.

Gesing A, Wang F, List EO, Berryman DE, Masternak MM, Lewinski A, Karbownik-Lewinska M, Kopchick JJ, Bartke A.

J Gerontol A Biol Sci Med Sci. 2015 Jan;70(1):44-52. doi: 10.1093/gerona/glu008. Epub 2014 Feb 18.


Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles.

List EO, Berryman DE, Funk K, Jara A, Kelder B, Wang F, Stout MB, Zhi X, Sun L, White TA, LeBrasseur NK, Pirtskhalava T, Tchkonia T, Jensen EA, Zhang W, Masternak MM, Kirkland JL, Miller RA, Bartke A, Kopchick JJ.

Endocrinology. 2014 May;155(5):1793-805. doi: 10.1210/en.2013-2086. Epub 2014 Feb 11.


Elevated systolic blood pressure in male GH transgenic mice is age dependent.

Jara A, Benner CM, Sim D, Liu X, List EO, Householder LA, Berryman DE, Kopchick JJ.

Endocrinology. 2014 Mar;155(3):975-86. doi: 10.1210/en.2013-1899. Epub 2013 Jan 1.


Repression of GH signaling: one extended life to live!

Berryman DE, List EO, Kopchick JJ.

Aging (Albany NY). 2013 Oct;5(10):723-4. No abstract available.


Chronic alterations in growth hormone/insulin-like growth factor-I signaling lead to changes in mouse tendon structure.

Nielsen RH, Clausen NM, Schjerling P, Larsen JO, Martinussen T, List EO, Kopchick JJ, Kjaer M, Heinemeier KM.

Matrix Biol. 2014 Feb;34:96-104. doi: 10.1016/j.matbio.2013.09.005. Epub 2013 Sep 28.


Evaluation of growth hormone (GH) action in mice: discovery of GH receptor antagonists and clinical indications.

Kopchick JJ, List EO, Kelder B, Gosney ES, Berryman DE.

Mol Cell Endocrinol. 2014 Apr 5;386(1-2):34-45. doi: 10.1016/j.mce.2013.09.004. Epub 2013 Sep 11. Review.

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