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Molecular landscape of acquired resistance to targeted therapy combinations in BRAF mutant colorectal cancer.

Oddo D, Sennott EM, Barault L, Valtorta E, Arena S, Cassingena A, Filiciotto G, Marzolla G, Elez E, van Geel RM, Bartolini A, Crisafulli G, Boscaro V, Godfrey JT, Buscarino M, Cancelliere C, Linnebacher M, Corti G, Truini M, Siravegna G, Grasselli J, Gallicchio M, Bernards R, Schellens JH, Tabernero J, Engelman JA, Sartore-Bianchi A, Bardelli A, Siena S, Corcoran RB, Di Nicolantonio F.

Cancer Res. 2016 Jun 16. pii: canres.0396.2016. [Epub ahead of print]


Generation, Characterization and Application of Antibodies Directed against HERV-H Gag Protein in Colorectal Samples.

Mullins CS, Hühns M, Krohn M, Peters S, Cheynet V, Oriol G, Guillotte M, Ducrot S, Mallet F, Linnebacher M.

PLoS One. 2016 Apr 27;11(4):e0153349. doi: 10.1371/journal.pone.0153349. eCollection 2016.


After Intestinal Transplantation Kidney Function Is Impaired by Downregulation of Epithelial Ion Transporters in the Ileum.

Reiner J, Hsieh CJ, Straarup C, Bodammer P, Schäffler H, Graepler F, Stüker D, Kratt T, Linnebacher M, Nadalin S, Witte M, Königsrainer A, Lamprecht G.

Transplant Proc. 2016 Mar;48(2):499-506. doi: 10.1016/j.transproceed.2015.12.068.


Establishment and characterization of HROC69 - a Crohn´s related colonic carcinoma cell line and its matched patient-derived xenograft.

Kuehn F, Mullins CS, Krohn M, Harnack C, Ramer R, Krämer OH, Klar E, Huehns M, Linnebacher M.

Sci Rep. 2016 Apr 18;6:24671. doi: 10.1038/srep24671.


Functional Characterization and Drug Response of Freshly Established Patient-Derived Tumor Models with CpG Island Methylator Phenotype.

Maletzki C, Huehns M, Knapp P, Waukosin N, Klar E, Prall F, Linnebacher M.

PLoS One. 2015 Nov 30;10(11):e0143194. doi: 10.1371/journal.pone.0143194. eCollection 2015.


Expression of young HERV-H loci in the course of colorectal carcinoma and correlation with molecular subtypes.

Pérot P, Mullins CS, Naville M, Bressan C, Hühns M, Gock M, Kühn F, Volff JN, Trillet-Lenoir V, Linnebacher M, Mallet F.

Oncotarget. 2015 Nov 24;6(37):40095-111. doi: 10.18632/oncotarget.5539.


Celecoxib increases lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1.

Schellhorn M, Haustein M, Frank M, Linnebacher M, Hinz B.

Oncotarget. 2015 Nov 17;6(36):39342-56. doi: 10.18632/oncotarget.5745.


Optimizing the process of nucleofection for professional antigen presenting cells.

Mullins CS, Wegner T, Klar E, Classen CF, Linnebacher M.

BMC Res Notes. 2015 Sep 24;8:472. doi: 10.1186/s13104-015-1446-8.


Stage-specific frequency and prognostic significance of aneuploidy in patients with sporadic colorectal cancer--a meta-analysis and current overview.

Laubert T, Freitag-Wolf S, Linnebacher M, König A, Vollmar B, Habermann JK; North German Tumorbank of Colorectal Cancer (ColoNet) consortium.

Int J Colorectal Dis. 2015 Aug;30(8):1015-28. doi: 10.1007/s00384-015-2259-x. Epub 2015 Jun 9. Review.


Assessing quality and functionality of DNA isolated from FFPE tissues through external quality assessment in tissue banks.

Ahmad-Nejad P, Duda A, Sucker A, Werner M, Bronsert P, Stickeler E, Reifenberger G, Malzkorn B, Oberländer M, Habermann JK, Bruch HP, Linnebacher M, Schadendorf D, Neumaier M.

Clin Chem Lab Med. 2015 Nov;53(12):1927-34. doi: 10.1515/cclm-2014-1202.


The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Medico E, Russo M, Picco G, Cancelliere C, Valtorta E, Corti G, Buscarino M, Isella C, Lamba S, Martinoglio B, Veronese S, Siena S, Sartore-Bianchi A, Beccuti M, Mottolese M, Linnebacher M, Cordero F, Di Nicolantonio F, Bardelli A.

Nat Commun. 2015 Apr 30;6:7002. doi: 10.1038/ncomms8002.


Arginine deprivation by arginine deiminase of Streptococcus pyogenes controls primary glioblastoma growth in vitro and in vivo.

Fiedler T, Strauss M, Hering S, Redanz U, William D, Rosche Y, Classen CF, Kreikemeyer B, Linnebacher M, Maletzki C.

Cancer Biol Ther. 2015;16(7):1047-55. doi: 10.1080/15384047.2015.1026478. Epub 2015 Mar 16.


MicroRNA-mRNA interactions in colorectal cancer and their role in tumor progression.

Amirkhah R, Schmitz U, Linnebacher M, Wolkenhauer O, Farazmand A.

Genes Chromosomes Cancer. 2015 Mar;54(3):129-41. doi: 10.1002/gcc.22231. Review.


Reactivity against microsatellite instability-induced frameshift mutations in patients with inflammatory bowel disease.

Kuehn F, Klar E, Bliemeister A, Linnebacher M.

World J Gastroenterol. 2015 Jan 7;21(1):221-8. doi: 10.3748/wjg.v21.i1.221.


Establishment and characterization of cell lines from chromosomal instable colorectal cancer.

Maletzki C, Gock M, Randow M, Klar E, Huehns M, Prall F, Linnebacher M.

World J Gastroenterol. 2015 Jan 7;21(1):164-76. doi: 10.3748/wjg.v21.i1.164.


E7080 (lenvatinib), a multi-targeted tyrosine kinase inhibitor, demonstrates antitumor activities against colorectal cancer xenografts.

Wiegering A, Korb D, Thalheimer A, Kämmerer U, Allmanritter J, Matthes N, Linnebacher M, Schlegel N, Klein I, Ergün S, Germer CT, Otto C.

Neoplasia. 2014 Nov 20;16(11):972-81. doi: 10.1016/j.neo.2014.09.008. eCollection 2014 Nov.


Biological and molecular effects of small molecule kinase inhibitors on low-passage human colorectal cancer cell lines.

Lange F, Franz B, Maletzki C, Linnebacher M, Hühns M, Jaster R.

Biomed Res Int. 2014;2014:568693. doi: 10.1155/2014/568693. Epub 2014 Sep 17.


Accounting for randomness in measurement and sampling in studying cancer cell population dynamics.

Ghavami S, Wolkenhauer O, Lahouti F, Ullah M, Linnebacher M.

IET Syst Biol. 2014 Oct;8(5):230-41. doi: 10.1049/iet-syb.2013.0031.


Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1.

Haustein M, Ramer R, Linnebacher M, Manda K, Hinz B.

Biochem Pharmacol. 2014 Nov 15;92(2):312-25. doi: 10.1016/j.bcp.2014.07.014. Epub 2014 Jul 25.


The impact of pyrvinium pamoate on colon cancer cell viability.

Wiegering A, Uthe FW, Hüttenrauch M, Mühling B, Linnebacher M, Krummenast F, Germer CT, Thalheimer A, Otto C.

Int J Colorectal Dis. 2014 Oct;29(10):1189-98. doi: 10.1007/s00384-014-1975-y. Epub 2014 Jul 26.

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