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Results: 1 to 20 of 30

1.

A Kinetic Model Explains Why Shorter and Less Affine Enzyme-recruiting Oligonucleotides Can Be More Potent.

Pedersen L, Hagedorn PH, Lindholm MW, Lindow M.

Mol Ther Nucleic Acids. 2014 Feb 18;3:e149. doi: 10.1038/mtna.2013.72.

2.

Quantum mechanical studies of DNA and LNA.

Koch T, Shim I, Lindow M, Ørum H, Bohr HG.

Nucleic Acid Ther. 2014 Apr;24(2):139-48. doi: 10.1089/nat.2013.0465. Epub 2014 Feb 3.

3.

microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus.

Leucci E, Patella F, Waage J, Holmstrøm K, Lindow M, Porse B, Kauppinen S, Lund AH.

Sci Rep. 2013;3:2535. doi: 10.1038/srep02535.

4.

Hepatotoxic potential of therapeutic oligonucleotides can be predicted from their sequence and modification pattern.

Hagedorn PH, Yakimov V, Ottosen S, Kammler S, Nielsen NF, Høg AM, Hedtjärn M, Meldgaard M, Møller MR, Orum H, Koch T, Lindow M.

Nucleic Acid Ther. 2013 Oct;23(5):302-10. doi: 10.1089/nat.2013.0436. Epub 2013 Aug 16.

5.

Discovering the first microRNA-targeted drug.

Lindow M, Kauppinen S.

J Cell Biol. 2012 Oct 29;199(3):407-12. doi: 10.1083/jcb.201208082.

6.

Assessing unintended hybridization-induced biological effects of oligonucleotides.

Lindow M, Vornlocher HP, Riley D, Kornbrust DJ, Burchard J, Whiteley LO, Kamens J, Thompson JD, Nochur S, Younis H, Bartz S, Parry J, Ferrari N, Henry SP, Levin AA.

Nat Biotechnol. 2012 Oct;30(10):920-3. doi: 10.1038/nbt.2376. No abstract available.

PMID:
23051805
7.

MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis.

Corsten MF, Papageorgiou A, Verhesen W, Carai P, Lindow M, Obad S, Summer G, Coort SL, Hazebroek M, van Leeuwen R, Gijbels MJ, Wijnands E, Biessen EA, De Winther MP, Stassen FR, Carmeliet P, Kauppinen S, Schroen B, Heymans S.

Circ Res. 2012 Aug 3;111(4):415-25. doi: 10.1161/CIRCRESAHA.112.267443. Epub 2012 Jun 19.

8.

Inhibition of microRNA function by antimiR oligonucleotides.

Stenvang J, Petri A, Lindow M, Obad S, Kauppinen S.

Silence. 2012 Jan 9;3(1):1. doi: 10.1186/1758-907X-3-1.

9.

mRNA expression profiling reveals conserved and non-conserved miR-140 targets.

Nicolas FE, Pais H, Schwach F, Lindow M, Kauppinen S, Moulton V, Dalmay T.

RNA Biol. 2011 Jul-Aug;8(4):607-15. doi: 10.4161/rna.8.4.15390. Epub 2011 Jul 1.

10.

Silencing of microRNA families by seed-targeting tiny LNAs.

Obad S, dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C, Lindow M, Stenvang J, Straarup EM, Hansen HF, Koch T, Pappin D, Hannon GJ, Kauppinen S.

Nat Genet. 2011 Mar 20;43(4):371-8. doi: 10.1038/ng.786.

11.

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice.

Castoldi M, Vujic Spasic M, Altamura S, Elmén J, Lindow M, Kiss J, Stolte J, Sparla R, D'Alessandro LA, Klingmüller U, Fleming RE, Longerich T, Gröne HJ, Benes V, Kauppinen S, Hentze MW, Muckenthaler MU.

J Clin Invest. 2011 Apr;121(4):1386-96. doi: 10.1172/JCI44883.

12.

Prediction of targets for microRNAs.

Lindow M.

Methods Mol Biol. 2011;703:311-7. doi: 10.1007/978-1-59745-248-9_21.

PMID:
21125499
13.

miRMaid: a unified programming interface for microRNA data resources.

Jacobsen A, Krogh A, Kauppinen S, Lindow M.

BMC Bioinformatics. 2010 Jan 14;11:29. doi: 10.1186/1471-2105-11-29.

14.

Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection.

Lanford RE, Hildebrandt-Eriksen ES, Petri A, Persson R, Lindow M, Munk ME, Kauppinen S, Ørum H.

Science. 2010 Jan 8;327(5962):198-201. doi: 10.1126/science.1178178. Epub 2009 Dec 3.

15.

Identification and analysis of miRNAs in human breast cancer and teratoma samples using deep sequencing.

Nygaard S, Jacobsen A, Lindow M, Eriksen J, Balslev E, Flyger H, Tolstrup N, Møller S, Krogh A, Litman T.

BMC Med Genomics. 2009 Jun 9;2:35. doi: 10.1186/1755-8794-2-35.

16.

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.

FANTOM Consortium, Suzuki H, Forrest AR, van Nimwegen E, Daub CO, Balwierz PJ, Irvine KM, Lassmann T, Ravasi T, Hasegawa Y, de Hoon MJ, Katayama S, Schroder K, Carninci P, Tomaru Y, Kanamori-Katayama M, Kubosaki A, Akalin A, Ando Y, Arner E, Asada M, Asahara H, Bailey T, Bajic VB, Bauer D, Beckhouse AG, Bertin N, Björkegren J, Brombacher F, Bulger E, Chalk AM, Chiba J, Cloonan N, Dawe A, Dostie J, Engström PG, Essack M, Faulkner GJ, Fink JL, Fredman D, Fujimori K, Furuno M, Gojobori T, Gough J, Grimmond SM, Gustafsson M, Hashimoto M, Hashimoto T, Hatakeyama M, Heinzel S, Hide W, Hofmann O, Hörnquist M, Huminiecki L, Ikeo K, Imamoto N, Inoue S, Inoue Y, Ishihara R, Iwayanagi T, Jacobsen A, Kaur M, Kawaji H, Kerr MC, Kimura R, Kimura S, Kimura Y, Kitano H, Koga H, Kojima T, Kondo S, Konno T, Krogh A, Kruger A, Kumar A, Lenhard B, Lennartsson A, Lindow M, Lizio M, Macpherson C, Maeda N, Maher CA, Maqungo M, Mar J, Matigian NA, Matsuda H, Mattick JS, Meier S, Miyamoto S, Miyamoto-Sato E, Nakabayashi K, Nakachi Y, Nakano M, Nygaard S, Okayama T, Okazaki Y, Okuda-Yabukami H, Orlando V, Otomo J, Pachkov M, Petrovsky N, Plessy C, Quackenbush J, Radovanovic A, Rehli M, Saito R, Sandelin A, Schmeier S, Schönbach C, Schwartz AS, Semple CA, Sera M, Severin J, Shirahige K, Simons C, St Laurent G, Suzuki M, Suzuki T, Sweet MJ, Taft RJ, Takeda S, Takenaka Y, Tan K, Taylor MS, Teasdale RD, Tegnér J, Teichmann S, Valen E, Wahlestedt C, Waki K, Waterhouse A, Wells CA, Winther O, Wu L, Yamaguchi K, Yanagawa H, Yasuda J, Zavolan M, Hume DA; Riken Omics Science Center, Arakawa T, Fukuda S, Imamura K, Kai C, Kaiho A, Kawashima T, Kawazu C, Kitazume Y, Kojima M, Miura H, Murakami K, Murata M, Ninomiya N, Nishiyori H, Noma S, Ogawa C, Sano T, Simon C, Tagami M, Takahashi Y, Kawai J, Hayashizaki Y.

Nat Genet. 2009 May;41(5):553-62. doi: 10.1038/ng.375. Epub 2009 Apr 19.

PMID:
19377474
17.

MicroRNA silencing in primates: towards development of novel therapeutics.

Petri A, Lindow M, Kauppinen S.

Cancer Res. 2009 Jan 15;69(2):393-5. doi: 10.1158/0008-5472.CAN-08-2749. Review.

18.

Targeting of microRNAs for therapeutics.

Stenvang J, Lindow M, Kauppinen S.

Biochem Soc Trans. 2008 Dec;36(Pt 6):1197-200. doi: 10.1042/BST0361197.

PMID:
19021524
19.

Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140.

Nicolas FE, Pais H, Schwach F, Lindow M, Kauppinen S, Moulton V, Dalmay T.

RNA. 2008 Dec;14(12):2513-20. doi: 10.1261/rna.1221108. Epub 2008 Oct 22.

20.

LNA-mediated microRNA silencing in non-human primates.

Elmén J, Lindow M, Schütz S, Lawrence M, Petri A, Obad S, Lindholm M, Hedtjärn M, Hansen HF, Berger U, Gullans S, Kearney P, Sarnow P, Straarup EM, Kauppinen S.

Nature. 2008 Apr 17;452(7189):896-9. doi: 10.1038/nature06783. Epub 2008 Mar 26.

PMID:
18368051
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