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Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex.

Chang HH, Lieber MR.

Nucleic Acids Res. 2016 Jun 20;44(11):4991-7. doi: 10.1093/nar/gkw456. Epub 2016 May 19.


The repetitive portion of the Xenopus IgH Mu switch region mediates orientation-dependent class switch recombination.

Zhang ZZ, Pannunzio NR, Lu Z, Hsu E, Yu K, Lieber MR.

Mol Immunol. 2015 Oct;67(2 Pt B):524-31. doi: 10.1016/j.molimm.2015.07.039. Epub 2015 Aug 12.


Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia.

Swaminathan S, Klemm L, Park E, Papaemmanuil E, Ford A, Kweon SM, Trageser D, Hasselfeld B, Henke N, Mooster J, Geng H, Schwarz K, Kogan SC, Casellas R, Schatz DG, Lieber MR, Greaves MF, Müschen M.

Nat Immunol. 2015 Jul;16(7):766-74. doi: 10.1038/ni.3160. Epub 2015 May 18.


Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair.

Reid DA, Keegan S, Leo-Macias A, Watanabe G, Strande NT, Chang HH, Oksuz BA, Fenyo D, Lieber MR, Ramsden DA, Rothenberg E.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2575-84. doi: 10.1073/pnas.1420115112. Epub 2015 May 4.


Effect of CpG dinucleotides within IgH switch region repeats on immunoglobulin class switch recombination.

Zhang ZZ, Hsieh CL, Okitsu CY, Han L, Yu K, Lieber MR.

Mol Immunol. 2015 Aug;66(2):284-9. doi: 10.1016/j.molimm.2015.04.005. Epub 2015 Apr 18.


Complexities due to single-stranded RNA during antibody detection of genomic rna:dna hybrids.

Zhang ZZ, Pannunzio NR, Hsieh CL, Yu K, Lieber MR.

BMC Res Notes. 2015 Apr 8;8:127. doi: 10.1186/s13104-015-1092-1.


Human lymphoid translocation fragile zones are hypomethylated and have accessible chromatin.

Lu Z, Lieber MR, Tsai AG, Pardo CE, Müschen M, Kladde MP, Hsieh CL.

Mol Cell Biol. 2015 Apr;35(7):1209-22. doi: 10.1128/MCB.01085-14. Epub 2015 Jan 26.


The role of G-density in switch region repeats for immunoglobulin class switch recombination.

Zhang ZZ, Pannunzio NR, Hsieh CL, Yu K, Lieber MR.

Nucleic Acids Res. 2014 Dec 1;42(21):13186-93. doi: 10.1093/nar/gku1100. Epub 2014 Nov 6.


The strength of an Ig switch region is determined by its ability to drive R loop formation and its number of WGCW sites.

Zhang ZZ, Pannunzio NR, Han L, Hsieh CL, Yu K, Lieber MR.

Cell Rep. 2014 Jul 24;8(2):557-69. doi: 10.1016/j.celrep.2014.06.021. Epub 2014 Jul 10.


Modeling of the RAG reaction mechanism.

Askary A, Shimazaki N, Bayat N, Lieber MR.

Cell Rep. 2014 Apr 24;7(2):307-15. doi: 10.1016/j.celrep.2014.03.005. Epub 2014 Apr 3.


Non-homologous end joining often uses microhomology: implications for alternative end joining.

Pannunzio NR, Li S, Watanabe G, Lieber MR.

DNA Repair (Amst). 2014 May;17:74-80. doi: 10.1016/j.dnarep.2014.02.006. Epub 2014 Mar 7. Review.


Evidence that the DNA endonuclease ARTEMIS also has intrinsic 5'-exonuclease activity.

Li S, Chang HH, Niewolik D, Hedrick MP, Pinkerton AB, Hassig CA, Schwarz K, Lieber MR.

J Biol Chem. 2014 Mar 14;289(11):7825-34. doi: 10.1074/jbc.M113.544874. Epub 2014 Feb 5.


Reproducibility and reliability of SNP analysis using human cellular DNA at or near nanogram levels.

Okitsu CY, Van Den Berg DJ, Lieber MR, Hsieh CL.

BMC Res Notes. 2013 Dec 6;6:515. doi: 10.1186/1756-0500-6-515.


BCL6 breaks occur at different AID sequence motifs in Ig-BCL6 and non-Ig-BCL6 rearrangements.

Lu Z, Tsai AG, Akasaka T, Ohno H, Jiang Y, Melnick AM, Greisman HA, Lieber MR.

Blood. 2013 May 30;121(22):4551-4. doi: 10.1182/blood-2012-10-464958. Epub 2013 Mar 8.


A noncatalytic function of the ligation complex during nonhomologous end joining.

Cottarel J, Frit P, Bombarde O, Salles B, Négrel A, Bernard S, Jeggo PA, Lieber MR, Modesti M, Calsou P.

J Cell Biol. 2013 Jan 21;200(2):173-86. doi: 10.1083/jcb.201203128.


Both CpG methylation and activation-induced deaminase are required for the fragility of the human bcl-2 major breakpoint region: implications for the timing of the breaks in the t(14;18) translocation.

Cui X, Lu Z, Kurosawa A, Klemm L, Bagshaw AT, Tsai AG, Gemmell N, Müschen M, Adachi N, Hsieh CL, Lieber MR.

Mol Cell Biol. 2013 Mar;33(5):947-57. doi: 10.1128/MCB.01436-12. Epub 2012 Dec 21.


IgH partner breakpoint sequences provide evidence that AID initiates t(11;14) and t(8;14) chromosomal breaks in mantle cell and Burkitt lymphomas.

Greisman HA, Lu Z, Tsai AG, Greiner TC, Yi HS, Lieber MR.

Blood. 2012 Oct 4;120(14):2864-7. doi: 10.1182/blood-2012-02-412791. Epub 2012 Aug 20.


Mechanistic basis for RAG discrimination between recombination sites and the off-target sites of human lymphomas.

Shimazaki N, Askary A, Swanson PC, Lieber MR.

Mol Cell Biol. 2012 Jan;32(2):365-75. doi: 10.1128/MCB.06187-11. Epub 2011 Nov 7.


Polynucleotide kinase and aprataxin-like forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3' exonuclease and can participate in DNA end joining in a biochemical system.

Li S, Kanno S, Watanabe R, Ogiwara H, Kohno T, Watanabe G, Yasui A, Lieber MR.

J Biol Chem. 2011 Oct 21;286(42):36368-77. doi: 10.1074/jbc.M111.287797. Epub 2011 Sep 1.


Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma.

Nambiar M, Goldsmith G, Moorthy BT, Lieber MR, Joshi MV, Choudhary B, Hosur RV, Raghavan SC.

Nucleic Acids Res. 2011 Feb;39(3):936-48. doi: 10.1093/nar/gkq824. Epub 2010 Sep 29.

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