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Results: 1 to 20 of 95

1.

LX4211 Therapy Reduces Postprandial Glucose Levels in Patients With Type 2 Diabetes Mellitus and Renal Impairment Despite Low Urinary Glucose Excretion.

Zambrowicz B, Lapuerta P, Strumph P, Banks P, Wilson A, Ogbaa I, Sands A, Powell D.

Clin Ther. 2014 Dec 16. pii: S0149-2918(14)00699-7. doi: 10.1016/j.clinthera.2014.10.026. [Epub ahead of print]

PMID:
25529979
[PubMed - as supplied by publisher]
2.

Reply to Lrp5 regulation of bone mass and gut serotonin synthesis.

Cui Y, Niziolek PJ, MacDonald BT, Alenina N, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Powell DR, He X, Bader M, Williams BO, Warman ML, Robling AG.

Nat Med. 2014 Nov 6;20(11):1229-30. doi: 10.1038/nm.3697. No abstract available.

PMID:
25375917
[PubMed - in process]
3.

Reaction profiling by ultra high-pressure liquid chromatography/time-of-flight mass spectrometry in support of the synthesis of DNA-encoded libraries.

Hargiss LO, Zipp GG, Jessop TC, Sun X, Keyes P, Rawlins DB, Liang Z, Park KJ, Gu H.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Nov 15;971:120-5. doi: 10.1016/j.jchromb.2014.09.001. Epub 2014 Sep 23.

PMID:
25282130
[PubMed - in process]
4.

Greater Dose-Ranging Effects on A1C Levels Than on Glucosuria With LX4211, a Dual Inhibitor of Sodium Glucose Transporters SGLT1 and SGLT2, in Type 2 Diabetes on Metformin Monotherapy.

Rosenstock J, Cefalu WT, Lapuerta P, Zambrowicz B, Ogbaa I, Banks P, Sands A.

Diabetes Care. 2014 Sep 11. pii: DC_140890. [Epub ahead of print]

PMID:
25216510
[PubMed - as supplied by publisher]
5.

Nephronophthisis and Retinal Degeneration in Tmem218-/- Mice: A Novel Mouse Model for Senior-Løken Syndrome?

Vogel P, Gelfman CM, Issa T, Payne BJ, Hansen GM, Read RW, Jones C, Pitcher MR, Ding ZM, DaCosta CM, Shadoan MK, Vance RB, Powell DR.

Vet Pathol. 2014 Aug 26. pii: 0300985814547392. [Epub ahead of print]

PMID:
25161209
[PubMed - as supplied by publisher]
6.

Autotaxin, LPA Receptors (1 and 5) Exert Disparate Functions in Tumor Cells Versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis.

Lee SC, Fujiwara Y, Liu J, Yue J, Shimizu Y, Norman DD, Wang Y, Tsukahara R, Szabo E, Patil R, Banerjee S, Miller DD, Balazs L, Ghosh MC, Waters CM, Oravecz T, Tigyi GJ.

Mol Cancer Res. 2014 Aug 26. pii: molcanres.0263.2014. [Epub ahead of print]

PMID:
25158955
[PubMed - as supplied by publisher]
7.

Novel inhibitors of the high-affinity L-proline transporter as potential therapeutic agents for the treatment of cognitive disorders.

Zipp GG, Barbosa J, Green MA, Terranova KM, Fink C, Yu XC, Nouraldeen A, Wilson A, Savelieva K, Lanthorn TH, David Kimball S.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3886-90. doi: 10.1016/j.bmcl.2014.06.049. Epub 2014 Jul 1.

PMID:
25037917
[PubMed - in process]
8.

Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response.

Hu J, Oda SK, Shotts K, Donovan EE, Strauch P, Pujanauski LM, Victorino F, Al-Shami A, Fujiwara Y, Tigyi G, Oravecz T, Pelanda R, Torres RM.

J Immunol. 2014 Jul 1;193(1):85-95. doi: 10.4049/jimmunol.1300429. Epub 2014 Jun 2.

PMID:
24890721
[PubMed - indexed for MEDLINE]
9.

Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.

Salojin KV, Hamman BD, Chang WC, Jhaver KG, Al-Shami A, Crisostomo J, Wilkins C, Digeorge-Foushee AM, Allen J, Patel N, Gopinathan S, Zhou J, Nouraldeen A, Jessop TC, Bagdanoff JT, Augeri DJ, Read R, Vogel P, Swaffield J, Wilson A, Platt KA, Carson KG, Main A, Zambrowicz BP, Oravecz T.

PLoS One. 2014 May 22;9(5):e98151. doi: 10.1371/journal.pone.0098151. eCollection 2014.

PMID:
24852423
[PubMed - in process]
Free PMC Article
10.

Effect of LX4211 on glucose homeostasis and body composition in preclinical models.

Powell DR, DaCosta CM, Smith M, Doree D, Harris A, Buhring L, Heydorn W, Nouraldeen A, Xiong W, Yalamanchili P, Mseeh F, Wilson A, Shadoan M, Zambrowicz B, Ding ZM.

J Pharmacol Exp Ther. 2014 Aug;350(2):232-42. doi: 10.1124/jpet.114.214304. Epub 2014 May 21.

PMID:
24849925
[PubMed - indexed for MEDLINE]
11.

Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit.

Ye GL, Savelieva KV, Vogel P, Baker KB, Mason S, Lanthorn TH, Rajan I.

Behav Brain Res. 2015 Jan 1;276:99-110. doi: 10.1016/j.bbr.2014.04.039. Epub 2014 Apr 29.

PMID:
24786331
[PubMed - in process]
12.

One-pot synthesis of 4-substituted 3-amino-2-cyanothiophenes involving O-ethyl thioformate.

Zhang H, Bednarz MS, Lim NK, Hernandez G, Wu W.

Org Lett. 2014 May 2;16(9):2522-5. doi: 10.1021/ol500895t. Epub 2014 Apr 18.

PMID:
24746285
[PubMed - indexed for MEDLINE]
13.

Malformation of Incisor Teeth in Grem2-/- Mice.

Vogel P, Liu J, Platt KA, Read RW, Thiel M, Vance RB, Brommage R.

Vet Pathol. 2014 May 5. [Epub ahead of print]

PMID:
24686385
[PubMed - as supplied by publisher]
14.

Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression.

Oda SK, Strauch P, Fujiwara Y, Al-Shami A, Oravecz T, Tigyi G, Pelanda R, Torres RM.

Cancer Immunol Res. 2013 Oct;1(4):245-55. doi: 10.1158/2326-6066.CIR-13-0043-T.

PMID:
24455753
[PubMed - in process]
Free PMC Article
15.

Healthcare transition from pediatric to adult medical homes in diabetes mellitus.

Turner JR, Schatz DA, Cusi K, Strumph P.

Endocr Pract. 2014 Jul;20(7):714-20. doi: 10.4158/EP13369.RA.

PMID:
24449671
[PubMed - in process]
16.

Integrin-α FG-GAP repeat-containing protein 2 is critical for normal B cell differentiation and controls disease development in a lupus model.

Al-Shami A, Crisostomo J, Wilkins C, Xu N, Humphries J, Chang WC, Anderson SJ, Oravecz T.

J Immunol. 2013 Oct 1;191(7):3789-98. doi: 10.4049/jimmunol.1203534. Epub 2013 Aug 30.

PMID:
23997217
[PubMed - indexed for MEDLINE]
Free Article
17.

Effects of LX4211, a dual sodium-dependent glucose cotransporters 1 and 2 inhibitor, on postprandial glucose, insulin, glucagon-like peptide 1, and peptide tyrosine tyrosine in a dose-timing study in healthy subjects.

Zambrowicz B, Ogbaa I, Frazier K, Banks P, Turnage A, Freiman J, Boehm KA, Ruff D, Powell D, Sands A.

Clin Ther. 2013 Aug;35(8):1162-1173.e8. doi: 10.1016/j.clinthera.2013.06.011. Epub 2013 Jul 31.

PMID:
23911260
[PubMed - indexed for MEDLINE]
18.

Study design and rationale of a dose-ranging trial of LX4211, a dual inhibitor of SGLT1 and SGLT2, in type 2 diabetes inadequately controlled on metformin monotherapy.

Lapuerta P, Rosenstock J, Zambrowicz B, Powell DR, Ogbaa I, Freiman J, Cefalu WT, Banks P, Frazier K, Kelly M, Sands A.

Clin Cardiol. 2013 Jul;36(7):367-71. doi: 10.1002/clc.22125. Epub 2013 Apr 29.

PMID:
23630033
[PubMed - indexed for MEDLINE]
19.

In vivo toxicology of excipients commonly employed in drug discovery in rats.

Gopinathan S, O'Neill E, Rodriguez LA, Champ R, Phillips M, Nouraldeen A, Wendt M, Wilson AG, Kramer JA.

J Pharmacol Toxicol Methods. 2013 Sep-Oct;68(2):284-95. doi: 10.1016/j.vascn.2013.02.009. Epub 2013 Mar 14.

PMID:
23499653
[PubMed - indexed for MEDLINE]
20.

LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose.

Powell DR, Smith M, Greer J, Harris A, Zhao S, DaCosta C, Mseeh F, Shadoan MK, Sands A, Zambrowicz B, Ding ZM.

J Pharmacol Exp Ther. 2013 May;345(2):250-9. doi: 10.1124/jpet.113.203364. Epub 2013 Mar 13.

PMID:
23487174
[PubMed - indexed for MEDLINE]
Free Article

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