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Results: 1 to 20 of 83

1.

Malformation of Incisor Teeth in Grem2-/- Mice.

Vogel P, Liu J, Platt KA, Read RW, Thiel M, Vance RB, Brommage R.

Vet Pathol. 2014 Mar 31. [Epub ahead of print]

PMID:
24686385
[PubMed - as supplied by publisher]
2.

LYSOPHOSPHATIDIC ACID INHIBITS CD8 T CELL ACTIVATION AND CONTROL OF TUMOR PROGRESSION.

Oda SK, Strauch P, Fujiwara Y, Al-Shami A, Oravecz T, Tigyi G, Pelanda R, Torres RM.

Cancer Immunol Res. 2013 Oct;1:245-255.

PMID:
24455753
[PubMed]
3.

Healthcare Transition from Pediatric to Adult Medical Homes in Diabetes Mellitus.

Turner JR, Schatz DA, Cusi K, Strumph P.

Endocr Pract. 2014 Jan 21:1-25. [Epub ahead of print]

PMID:
24449671
[PubMed - as supplied by publisher]
4.

Integrin-α FG-GAP repeat-containing protein 2 is critical for normal B cell differentiation and controls disease development in a lupus model.

Al-Shami A, Crisostomo J, Wilkins C, Xu N, Humphries J, Chang WC, Anderson SJ, Oravecz T.

J Immunol. 2013 Oct 1;191(7):3789-98. doi: 10.4049/jimmunol.1203534. Epub 2013 Aug 30.

PMID:
23997217
[PubMed - indexed for MEDLINE]
5.

Effects of LX4211, a dual sodium-dependent glucose cotransporters 1 and 2 inhibitor, on postprandial glucose, insulin, glucagon-like peptide 1, and peptide tyrosine tyrosine in a dose-timing study in healthy subjects.

Zambrowicz B, Ogbaa I, Frazier K, Banks P, Turnage A, Freiman J, Boehm KA, Ruff D, Powell D, Sands A.

Clin Ther. 2013 Aug;35(8):1162-1173.e8. doi: 10.1016/j.clinthera.2013.06.011. Epub 2013 Jul 31.

PMID:
23911260
[PubMed - indexed for MEDLINE]
6.

Study design and rationale of a dose-ranging trial of LX4211, a dual inhibitor of SGLT1 and SGLT2, in type 2 diabetes inadequately controlled on metformin monotherapy.

Lapuerta P, Rosenstock J, Zambrowicz B, Powell DR, Ogbaa I, Freiman J, Cefalu WT, Banks P, Frazier K, Kelly M, Sands A.

Clin Cardiol. 2013 Jul;36(7):367-71. doi: 10.1002/clc.22125. Epub 2013 Apr 29.

PMID:
23630033
[PubMed - indexed for MEDLINE]
7.

In vivo toxicology of excipients commonly employed in drug discovery in rats.

Gopinathan S, O'Neill E, Rodriguez LA, Champ R, Phillips M, Nouraldeen A, Wendt M, Wilson AG, Kramer JA.

J Pharmacol Toxicol Methods. 2013 Sep-Oct;68(2):284-95. doi: 10.1016/j.vascn.2013.02.009. Epub 2013 Mar 14.

PMID:
23499653
[PubMed - indexed for MEDLINE]
8.

LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose.

Powell DR, Smith M, Greer J, Harris A, Zhao S, DaCosta C, Mseeh F, Shadoan MK, Sands A, Zambrowicz B, Ding ZM.

J Pharmacol Exp Ther. 2013 May;345(2):250-9. doi: 10.1124/jpet.113.203364. Epub 2013 Mar 13.

PMID:
23487174
[PubMed - indexed for MEDLINE]
9.

Effects of LX4211, a dual SGLT1/SGLT2 inhibitor, plus sitagliptin on postprandial active GLP-1 and glycemic control in type 2 diabetes.

Zambrowicz B, Ding ZM, Ogbaa I, Frazier K, Banks P, Turnage A, Freiman J, Smith M, Ruff D, Sands A, Powell D.

Clin Ther. 2013 Mar;35(3):273-285.e7. doi: 10.1016/j.clinthera.2013.01.010. Epub 2013 Feb 21.

PMID:
23433601
[PubMed - indexed for MEDLINE]
10.

Improved glycemic control in mice lacking Sglt1 and Sglt2.

Powell DR, DaCosta CM, Gay J, Ding ZM, Smith M, Greer J, Doree D, Jeter-Jones S, Mseeh F, Rodriguez LA, Harris A, Buhring L, Platt KA, Vogel P, Brommage R, Shadoan MK, Sands AT, Zambrowicz B.

Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E117-30. doi: 10.1152/ajpendo.00439.2012. Epub 2012 Nov 13.

PMID:
23149623
[PubMed - indexed for MEDLINE]
Free Article
11.

Keratinocyte migration in the developing eyelid requires LIMK2.

Rice DS, Hansen GM, Liu F, Crist MJ, Newhouse MM, Potter D, Xu N, Abuin A, Vogel PJ, Zambrowicz BP.

PLoS One. 2012;7(10):e47168. doi: 10.1371/journal.pone.0047168. Epub 2012 Oct 5.

PMID:
23071748
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Characterization of PTPRG in knockdown and phosphatase-inactive mutant mice and substrate trapping analysis of PTPRG in mammalian cells.

Zhang W, Savelieva KV, Tran DT, Pogorelov VM, Cullinan EB, Baker KB, Platt KA, Hu S, Rajan I, Xu N, Lanthorn TH.

PLoS One. 2012;7(9):e45500. doi: 10.1371/journal.pone.0045500. Epub 2012 Sep 20.

PMID:
23029056
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Evaluation of transporter-mediated hepatic uptake in a non-radioactive high-throughput assay: a study of kinetics, species difference and plasma protein effect.

Li L, Nouraldeen A, Wilson AG.

Xenobiotica. 2013 Mar;43(3):253-62. doi: 10.3109/00498254.2012.713146. Epub 2012 Aug 28.

PMID:
22928802
[PubMed - indexed for MEDLINE]
14.

LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial.

Zambrowicz B, Freiman J, Brown PM, Frazier KS, Turnage A, Bronner J, Ruff D, Shadoan M, Banks P, Mseeh F, Rawlins DB, Goodwin NC, Mabon R, Harrison BA, Wilson A, Sands A, Powell DR.

Clin Pharmacol Ther. 2012 Aug;92(2):158-69. doi: 10.1038/clpt.2012.58. Epub 2012 Jul 4.

PMID:
22739142
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Amelogenesis imperfecta and other biomineralization defects in Fam20a and Fam20c null mice.

Vogel P, Hansen GM, Read RW, Vance RB, Thiel M, Liu J, Wronski TJ, Smith DD, Jeter-Jones S, Brommage R.

Vet Pathol. 2012 Nov;49(6):998-1017. doi: 10.1177/0300985812453177. Epub 2012 Jun 25.

PMID:
22732358
[PubMed - in process]
Free Article
16.

Congenital hydrocephalus in genetically engineered mice.

Vogel P, Read RW, Hansen GM, Payne BJ, Small D, Sands AT, Zambrowicz BP.

Vet Pathol. 2012 Jan;49(1):166-81. doi: 10.1177/0300985811415708. Epub 2011 Jul 11.

PMID:
21746835
[PubMed - in process]
Free Article
17.

Frizzled 4 is required for retinal angiogenesis and maintenance of the blood-retina barrier.

Paes KT, Wang E, Henze K, Vogel P, Read R, Suwanichkul A, Kirkpatrick LL, Potter D, Newhouse MM, Rice DS.

Invest Ophthalmol Vis Sci. 2011 Aug 16;52(9):6452-61. doi: 10.1167/iovs.10-7146.

PMID:
21743011
[PubMed - indexed for MEDLINE]
Free Article
18.

The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome.

Brown PM, Drossman DA, Wood AJ, Cline GA, Frazier KS, Jackson JI, Bronner J, Freiman J, Zambrowicz B, Sands A, Gershon MD.

Gastroenterology. 2011 Aug;141(2):507-16. doi: 10.1053/j.gastro.2011.05.005. Epub 2011 May 18.

PMID:
21684281
[PubMed - indexed for MEDLINE]
19.

Cardiomyopathy in α-Kinase 3 (ALPK3)-Deficient Mice.

Van Sligtenhorst I, Ding ZM, Shi ZZ, Read RW, Hansen G, Vogel P.

Vet Pathol. 2012 Jan;49(1):131-41. doi: 10.1177/0300985811402841. Epub 2011 Mar 25.

PMID:
21441111
[PubMed - in process]
Free Article
20.

The role of pharmacokinetic and pharmacokinetic/pharmacodynamic modeling in drug discovery and development.

Yu XQ, Wilson AG.

Future Med Chem. 2010 Jun;2(6):923-8. doi: 10.4155/fmc.10.181. No abstract available.

PMID:
21426110
[PubMed - indexed for MEDLINE]
Free Article

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