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Results: 1 to 20 of 90

1.

Novel inhibitors of the high-affinity l-proline transporter as potential therapeutic agents for the treatment of cognitive disorders.

Zipp GG, Barbosa J, Green MA, Terranova KM, Fink C, Yu XC, Nouraldeen A, Wilson A, Savelieva K, Lanthorn TH, David Kimball S.

Bioorg Med Chem Lett. 2014 Jul 1. pii: S0960-894X(14)00677-5. doi: 10.1016/j.bmcl.2014.06.049. [Epub ahead of print]

PMID:
25037917
[PubMed - as supplied by publisher]
2.

Telotristat etiprate in carcinoid syndrome not adequately controlled by octreotide.

Kulke MH, O'Dorisio T, Phan A, Bergsland EK, Law L, Banks P, Freiman J, Frazier K, Jackson J, Yao JC, Kvols L, Lapuerta P, Zambrowicz B, Fleming D, Sands A.

Endocr Relat Cancer. 2014 Jul 10. pii: ERC-14-0173. [Epub ahead of print]

PMID:
25012985
[PubMed - as supplied by publisher]
3.

Lysophosphatidic Acid receptor 5 inhibits B cell antigen receptor signaling and antibody response.

Hu J, Oda SK, Shotts K, Donovan EE, Strauch P, Pujanauski LM, Victorino F, Al-Shami A, Fujiwara Y, Tigyi G, Oravecz T, Pelanda R, Torres RM.

J Immunol. 2014 Jul 1;193(1):85-95. doi: 10.4049/jimmunol.1300429. Epub 2014 Jun 2.

PMID:
24890721
[PubMed - in process]
4.

Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.

Salojin KV, Hamman BD, Chang WC, Jhaver KG, Al-Shami A, Crisostomo J, Wilkins C, Digeorge-Foushee AM, Allen J, Patel N, Gopinathan S, Zhou J, Nouraldeen A, Jessop TC, Bagdanoff JT, Augeri DJ, Read R, Vogel P, Swaffield J, Wilson A, Platt KA, Carson KG, Main A, Zambrowicz BP, Oravecz T.

PLoS One. 2014 May 22;9(5):e98151. doi: 10.1371/journal.pone.0098151. eCollection 2014.

PMID:
24852423
[PubMed - in process]
Free PMC Article
5.

Effect of LX4211 on Glucose Homeostasis and Body Composition in Preclinical Models.

Powell DR, DaCosta CM, Smith M, Doree D, Harris A, Buhring L, Heydorn W, Nouraldeen A, Xiong W, Yalamanchili P, Mseeh F, Wilson A, Shadoan M, Zambrowicz B, Ding ZM.

J Pharmacol Exp Ther. 2014 Aug;350(2):232-42. doi: 10.1124/jpet.114.214304. Epub 2014 May 21.

PMID:
24849925
[PubMed - in process]
Free Article
6.

Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit.

Ye GL, Savelieva KV, Vogel P, Baker KB, Mason S, Lanthorn TH, Rajan I.

Behav Brain Res. 2014 Apr 29. pii: S0166-4328(14)00257-5. doi: 10.1016/j.bbr.2014.04.039. [Epub ahead of print]

PMID:
24786331
[PubMed - as supplied by publisher]
7.

One-pot synthesis of 4-substituted 3-amino-2-cyanothiophenes involving O-ethyl thioformate.

Zhang H, Bednarz MS, Lim NK, Hernandez G, Wu W.

Org Lett. 2014 May 2;16(9):2522-5. doi: 10.1021/ol500895t. Epub 2014 Apr 18.

PMID:
24746285
[PubMed - in process]
8.

Malformation of Incisor Teeth in Grem2-/- Mice.

Vogel P, Liu J, Platt KA, Read RW, Thiel M, Vance RB, Brommage R.

Vet Pathol. 2014 May 5. [Epub ahead of print]

PMID:
24686385
[PubMed - as supplied by publisher]
9.

Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression.

Oda SK, Strauch P, Fujiwara Y, Al-Shami A, Oravecz T, Tigyi G, Pelanda R, Torres RM.

Cancer Immunol Res. 2013 Oct;1(4):245-55. doi: 10.1158/2326-6066.CIR-13-0043-T.

PMID:
24455753
[PubMed - in process]
10.

Healthcare transition from pediatric to adult medical homes in diabetes mellitus.

Turner JR, Schatz DA, Cusi K, Strumph P.

Endocr Pract. 2014 Jul 1;20(7):714-20. doi: 10.4158/EP13369.RA.

PMID:
24449671
[PubMed - in process]
11.

Integrin-α FG-GAP repeat-containing protein 2 is critical for normal B cell differentiation and controls disease development in a lupus model.

Al-Shami A, Crisostomo J, Wilkins C, Xu N, Humphries J, Chang WC, Anderson SJ, Oravecz T.

J Immunol. 2013 Oct 1;191(7):3789-98. doi: 10.4049/jimmunol.1203534. Epub 2013 Aug 30.

PMID:
23997217
[PubMed - indexed for MEDLINE]
12.

Effects of LX4211, a dual sodium-dependent glucose cotransporters 1 and 2 inhibitor, on postprandial glucose, insulin, glucagon-like peptide 1, and peptide tyrosine tyrosine in a dose-timing study in healthy subjects.

Zambrowicz B, Ogbaa I, Frazier K, Banks P, Turnage A, Freiman J, Boehm KA, Ruff D, Powell D, Sands A.

Clin Ther. 2013 Aug;35(8):1162-1173.e8. doi: 10.1016/j.clinthera.2013.06.011. Epub 2013 Jul 31.

PMID:
23911260
[PubMed - indexed for MEDLINE]
Free Article
13.

Study design and rationale of a dose-ranging trial of LX4211, a dual inhibitor of SGLT1 and SGLT2, in type 2 diabetes inadequately controlled on metformin monotherapy.

Lapuerta P, Rosenstock J, Zambrowicz B, Powell DR, Ogbaa I, Freiman J, Cefalu WT, Banks P, Frazier K, Kelly M, Sands A.

Clin Cardiol. 2013 Jul;36(7):367-71. doi: 10.1002/clc.22125. Epub 2013 Apr 29.

PMID:
23630033
[PubMed - indexed for MEDLINE]
14.

In vivo toxicology of excipients commonly employed in drug discovery in rats.

Gopinathan S, O'Neill E, Rodriguez LA, Champ R, Phillips M, Nouraldeen A, Wendt M, Wilson AG, Kramer JA.

J Pharmacol Toxicol Methods. 2013 Sep-Oct;68(2):284-95. doi: 10.1016/j.vascn.2013.02.009. Epub 2013 Mar 14.

PMID:
23499653
[PubMed - indexed for MEDLINE]
15.

LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose.

Powell DR, Smith M, Greer J, Harris A, Zhao S, DaCosta C, Mseeh F, Shadoan MK, Sands A, Zambrowicz B, Ding ZM.

J Pharmacol Exp Ther. 2013 May;345(2):250-9. doi: 10.1124/jpet.113.203364. Epub 2013 Mar 13.

PMID:
23487174
[PubMed - indexed for MEDLINE]
Free Article
16.

Effects of LX4211, a dual SGLT1/SGLT2 inhibitor, plus sitagliptin on postprandial active GLP-1 and glycemic control in type 2 diabetes.

Zambrowicz B, Ding ZM, Ogbaa I, Frazier K, Banks P, Turnage A, Freiman J, Smith M, Ruff D, Sands A, Powell D.

Clin Ther. 2013 Mar;35(3):273-285.e7. doi: 10.1016/j.clinthera.2013.01.010. Epub 2013 Feb 21.

PMID:
23433601
[PubMed - indexed for MEDLINE]
17.

Improved glycemic control in mice lacking Sglt1 and Sglt2.

Powell DR, DaCosta CM, Gay J, Ding ZM, Smith M, Greer J, Doree D, Jeter-Jones S, Mseeh F, Rodriguez LA, Harris A, Buhring L, Platt KA, Vogel P, Brommage R, Shadoan MK, Sands AT, Zambrowicz B.

Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E117-30. doi: 10.1152/ajpendo.00439.2012. Epub 2012 Nov 13.

PMID:
23149623
[PubMed - indexed for MEDLINE]
Free Article
18.

Keratinocyte migration in the developing eyelid requires LIMK2.

Rice DS, Hansen GM, Liu F, Crist MJ, Newhouse MM, Potter D, Xu N, Abuin A, Vogel PJ, Zambrowicz BP.

PLoS One. 2012;7(10):e47168. doi: 10.1371/journal.pone.0047168. Epub 2012 Oct 5.

PMID:
23071748
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Characterization of PTPRG in knockdown and phosphatase-inactive mutant mice and substrate trapping analysis of PTPRG in mammalian cells.

Zhang W, Savelieva KV, Tran DT, Pogorelov VM, Cullinan EB, Baker KB, Platt KA, Hu S, Rajan I, Xu N, Lanthorn TH.

PLoS One. 2012;7(9):e45500. doi: 10.1371/journal.pone.0045500. Epub 2012 Sep 20.

PMID:
23029056
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Evaluation of transporter-mediated hepatic uptake in a non-radioactive high-throughput assay: a study of kinetics, species difference and plasma protein effect.

Li L, Nouraldeen A, Wilson AG.

Xenobiotica. 2013 Mar;43(3):253-62. doi: 10.3109/00498254.2012.713146. Epub 2012 Aug 28.

PMID:
22928802
[PubMed - indexed for MEDLINE]

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