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Intracellular chromobody delivery by mesoporous silica nanoparticles for antigen targeting and visualization in real time.

Chiu HY, Deng W, Engelke H, Helma J, Leonhardt H, Bein T.

Sci Rep. 2016 May 13;6:25019. doi: 10.1038/srep25019.


Visualization of Genomic Loci in Living Cells with a Fluorescent CRISPR/Cas9 System.

Anton T, Leonhardt H, Markaki Y.

Methods Mol Biol. 2016;1411:407-17. doi: 10.1007/978-1-4939-3530-7_25.


Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network.

Crevenna AH, Blank B, Maiser A, Emin D, Prescher J, Beck G, Kienzle C, Bartnik K, Habermann B, Pakdel M, Leonhardt H, Lamb DC, von Blume J.

J Cell Biol. 2016 May 9;213(3):305-14. doi: 10.1083/jcb.201601089. Epub 2016 May 2.


Poly(ADP-ribosyl)ation of methyl CpG binding protein 2 regulates chromatin structure.

Becker A, Zhang P, Allmann L, Meilinger D, Bertulat B, Eck D, Hofstaetter M, Bartolomei G, Hottiger MO, Schreiber V, Leonhardt H, Cardoso MC.

J Biol Chem. 2016 Apr 22;291(17):9382. doi: 10.1074/jbc.A115.698357. No abstract available.


4D Visualization of replication foci in mammalian cells corresponding to individual replicons.

Chagin VO, Casas-Delucchi CS, Reinhart M, Schermelleh L, Markaki Y, Maiser A, Bolius JJ, Bensimon A, Fillies M, Domaing P, Rozanov YM, Leonhardt H, Cardoso MC.

Nat Commun. 2016 Apr 7;7:11231. doi: 10.1038/ncomms11231.


Current Status: Site-Specific Antibody Drug Conjugates.

Schumacher D, Hackenberger CP, Leonhardt H, Helma J.

J Clin Immunol. 2016 Mar 22. [Epub ahead of print]


Cell-substrate impedance fluctuations of single amoeboid cells encode cell-shape and adhesion dynamics.

Leonhardt H, Gerhardt M, Höppner N, Krüger K, Tarantola M, Beta C.

Phys Rev E. 2016 Jan;93(1):012414. doi: 10.1103/PhysRevE.93.012414. Epub 2016 Jan 25.


Poly(ADP-ribosyl)ation of Methyl CpG Binding Domain Protein 2 Regulates Chromatin Structure.

Becker A, Zhang P, Allmann L, Meilinger D, Bertulat B, Eck D, Hofstaetter M, Bartolomei G, Hottiger MO, Schreiber V, Leonhardt H, Cardoso MC.

J Biol Chem. 2016 Mar 4;291(10):4873-81. doi: 10.1074/jbc.M115.698357. Epub 2016 Jan 15. Erratum in: J Biol Chem. 2016 Apr 22;291(17):9382.


Generation of an alpaca-derived nanobody recognizing γ-H2AX.

Rajan M, Mortusewicz O, Rothbauer U, Hastert FD, Schmidthals K, Rapp A, Leonhardt H, Cardoso MC.

FEBS Open Bio. 2015 Sep 21;5:779-88. doi: 10.1016/j.fob.2015.09.005. eCollection 2015.


Versatile and Efficient Site-Specific Protein Functionalization by Tubulin Tyrosine Ligase.

Schumacher D, Helma J, Mann FA, Pichler G, Natale F, Krause E, Cardoso MC, Hackenberger CP, Leonhardt H.

Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13787-91. doi: 10.1002/anie.201505456. Epub 2015 Sep 25.


Energy profile of nanobody-GFP complex under force.

Klamecka K, Severin PM, Milles LF, Gaub HE, Leonhardt H.

Phys Biol. 2015 Sep 10;12(5):056009. doi: 10.1088/1478-3975/12/5/056009.


DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination.

Qin W, Wolf P, Liu N, Link S, Smets M, La Mastra F, Forné I, Pichler G, Hörl D, Fellinger K, Spada F, Bonapace IM, Imhof A, Harz H, Leonhardt H.

Cell Res. 2015 Aug;25(8):911-29. doi: 10.1038/cr.2015.72. Epub 2015 Jun 12.


Nanobodies and recombinant binders in cell biology.

Helma J, Cardoso MC, Muyldermans S, Leonhardt H.

J Cell Biol. 2015 Jun 8;209(5):633-44. doi: 10.1083/jcb.201409074. Review.


A modular open platform for systematic functional studies under physiological conditions.

Mulholland CB, Smets M, Schmidtmann E, Leidescher S, Markaki Y, Hofweber M, Qin W, Manzo M, Kremmer E, Thanisch K, Bauer C, Rombaut P, Herzog F, Leonhardt H, Bultmann S.

Nucleic Acids Res. 2015 Sep 30;43(17):e112. doi: 10.1093/nar/gkv550. Epub 2015 May 24.


EGFR/ERBB receptors differentially modulate sebaceous lipogenesis.

Dahlhoff M, Camera E, Ludovici M, Picardo M, Müller U, Leonhardt H, Zouboulis CC, Schneider MR.

FEBS Lett. 2015 May 22;589(12):1376-82. doi: 10.1016/j.febslet.2015.04.003. Epub 2015 Apr 15.


The CENP-T C-terminus is exclusively proximal to H3.1 and not to H3.2 or H3.3.

Abendroth C, Hofmeister A, Hake SB, Kamweru PK, Miess E, Dornblut C, Küffner I, Deng W, Leonhardt H, Orthaus S, Hoischen C, Diekmann S.

Int J Mol Sci. 2015 Mar 12;16(3):5839-63. doi: 10.3390/ijms16035839.


An intracellular nanotrap redirects proteins and organelles in live bacteria.

Borg S, Popp F, Hofmann J, Leonhardt H, Rothbauer U, Schüler D.

MBio. 2015 Jan 13;6(1). pii: e02117-14. doi: 10.1128/mBio.02117-14.


Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT).

Bauer C, Göbel K, Nagaraj N, Colantuoni C, Wang M, Müller U, Kremmer E, Rottach A, Leonhardt H.

J Biol Chem. 2015 Feb 20;290(8):4801-12. doi: 10.1074/jbc.M114.605881. Epub 2015 Jan 7.


Parallel force assay for protein-protein interactions.

Aschenbrenner D, Pippig DA, Klamecka K, Limmer K, Leonhardt H, Gaub HE.

PLoS One. 2014 Dec 29;9(12):e115049. doi: 10.1371/journal.pone.0115049. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0119695.


Serum anti-Müllerian hormone and ovarian morphology assessed by magnetic resonance imaging in response to acupuncture and exercise in women with polycystic ovary syndrome: secondary analyses of a randomized controlled trial.

Leonhardt H, Hellström M, Gull B, Lind AK, Nilsson L, Janson PO, Stener-Victorin E.

Acta Obstet Gynecol Scand. 2015 Mar;94(3):279-87. doi: 10.1111/aogs.12571. Epub 2015 Jan 28.

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