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Assessment of infarct-specific cardiac motion dysfunction using modeling and multimodal magnetic resonance merging.

Leong CO, Liew YM, Bilgen M, Abdul Aziz YF, Chee KH, Chiam YK, Lim E.

J Magn Reson Imaging. 2016 Jul 15. doi: 10.1002/jmri.25390. [Epub ahead of print]


Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival.

Tiong KH, Tan BS, Choo HL, Chung FF, Hii LW, Tan SH, Khor NT, Wong SF, See SJ, Tan YF, Rosli R, Cheong SK, Leong CO.

Oncotarget. 2016 May 12. doi: 10.18632/oncotarget.9328. [Epub ahead of print]


Cytochrome P450 2W1 (CYP2W1) in Colorectal Cancers.

Chung FF, Mai CW, Ng PY, Leong CO.

Curr Cancer Drug Targets. 2016;16(1):71-8.


Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery.

Stone EL, Citossi F, Singh R, Kaur B, Gaskell M, Farmer PB, Monks A, Hose C, Stevens MF, Leong CO, Stocks M, Kellam B, Marlow M, Bradshaw TD.

Bioorg Med Chem. 2015 Nov 1;23(21):6891-9. doi: 10.1016/j.bmc.2015.09.052. Epub 2015 Oct 3.


Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells.

Soo JS, Ng CH, Tan SH, Malik RA, Teh YC, Tan BS, Ho GF, See MH, Taib NA, Yip CH, Chung FF, Hii LW, Teo SH, Leong CO.

Apoptosis. 2015 Oct;20(10):1373-87. doi: 10.1007/s10495-015-1158-5.


Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity.

Voon YL, Ahmad M, Wong PF, Husaini R, Ng WT, Leong CO, Lane DP, Khoo AS.

Oncol Rep. 2015 Oct;34(4):1692-700. doi: 10.3892/or.2015.4177. Epub 2015 Aug 5.


Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF).

Tan BS, Tiong KH, Choo HL, Chung FF, Hii LW, Tan SH, Yap IK, Pani S, Khor NT, Wong SF, Rosli R, Cheong SK, Leong CO.

Cell Death Dis. 2015 Jul 16;6:e1826. doi: 10.1038/cddis.2015.191.


Regional assessment of LV wall in infarcted heart using tagged MRI and cardiac modelling.

Jahanzad Z, Liew YM, Bilgen M, McLaughlin RA, Leong CO, Chee KH, Aziz YF, Ung NM, Lai KW, Ng SC, Lim E.

Phys Med Biol. 2015 May 21;60(10):4015-31. doi: 10.1088/0031-9155/60/10/4015. Epub 2015 Apr 28.


Orofacial pain of muscular origin is not associated with herpes virus-6 infection: a pilot study.

Shoji Y, Choo HL, Leong CO, Oo AL, Townsend G.

J Oral Facial Pain Headache. 2014 Fall;28(4):346-9. doi: 10.11607/ofph.1095.


Toxicity of single-walled carbon nanotubes.

Ong LC, Chung FF, Tan YF, Leong CO.

Arch Toxicol. 2016 Jan;90(1):103-18. doi: 10.1007/s00204-014-1376-6. Epub 2014 Oct 2.


Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2/M cell cycle arrest targeting microtubules.

Raja VJ, Lim KH, Leong CO, Kam TS, Bradshaw TD.

Invest New Drugs. 2014 Oct;32(5):838-50. doi: 10.1007/s10637-014-0126-1. Epub 2014 Jun 15.


Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers.

Tiong KH, Mah LY, Leong CO.

Apoptosis. 2013 Dec;18(12):1447-68. doi: 10.1007/s10495-013-0886-7. Review.


6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor ╬│ (PPAR╬│).

Tan BS, Kang O, Mai CW, Tiong KH, Khoo AS, Pichika MR, Bradshaw TD, Leong CO.

Cancer Lett. 2013 Aug 9;336(1):127-39. doi: 10.1016/j.canlet.2013.04.014. Epub 2013 Apr 21.


Triple-negative breast cancer is associated with EGFR, CK5/6 and c-KIT expression in Malaysian women.

Kanapathy Pillai SK, Tay A, Nair S, Leong CO.

BMC Clin Pathol. 2012 Sep 26;12:18. doi: 10.1186/1472-6890-12-18.


Suppression of BCL-2 synergizes cisplatin sensitivity in nasopharyngeal carcinoma cells.

Low SY, Tan BS, Choo HL, Tiong KH, Khoo AS, Leong CO.

Cancer Lett. 2012 Jan 28;314(2):166-75. doi: 10.1016/j.canlet.2011.09.025. Epub 2011 Oct 8.


CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells.

Tan BS, Tiong KH, Muruhadas A, Randhawa N, Choo HL, Bradshaw TD, Stevens MF, Leong CO.

Mol Cancer Ther. 2011 Oct;10(10):1982-92. doi: 10.1158/1535-7163.MCT-11-0391. Epub 2011 Aug 10.


BRCA1-associated epigenetic regulation of p73 mediates an effector pathway for chemosensitivity in ovarian carcinoma.

Ibrahim N, He L, Leong CO, Xing D, Karlan BY, Swisher EM, Rueda BR, Orsulic S, Ellisen LW.

Cancer Res. 2010 Sep 15;70(18):7155-65. doi: 10.1158/0008-5472.CAN-10-0668. Epub 2010 Aug 31.


Rapamycin synergizes cisplatin sensitivity in basal-like breast cancer cells through up-regulation of p73.

Wong SW, Tiong KH, Kong WY, Yue YC, Chua CH, Lim JY, Lee CY, Quah SI, Fow C, Chung C, So I, Tan BS, Choo HL, Rosli R, Cheong SK, Leong CO.

Breast Cancer Res Treat. 2011 Jul;128(2):301-13. doi: 10.1007/s10549-010-1055-0. Epub 2010 Aug 5.


Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer.

Silver DP, Richardson AL, Eklund AC, Wang ZC, Szallasi Z, Li Q, Juul N, Leong CO, Calogrias D, Buraimoh A, Fatima A, Gelman RS, Ryan PD, Tung NM, De Nicolo A, Ganesan S, Miron A, Colin C, Sgroi DC, Ellisen LW, Winer EP, Garber JE.

J Clin Oncol. 2010 Mar 1;28(7):1145-53. doi: 10.1200/JCO.2009.22.4725. Epub 2010 Jan 25.


Mutant p53 mediates survival of breast cancer cells.

Lim LY, Vidnovic N, Ellisen LW, Leong CO.

Br J Cancer. 2009 Nov 3;101(9):1606-12. doi: 10.1038/sj.bjc.6605335. Epub 2009 Sep 22.

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