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Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data. An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).

Cooper C, Bardin T, Brandi ML, Cacoub P, Caminis J, Civitelli R, Cutolo M, Dere W, Devogelaer JP, Diez-Perez A, Einhorn TA, Emonts P, Ethgen O, Kanis JA, Kaufman JM, Kvien TK, Lems WF, McCloskey E, Miossec P, Reiter S, Ringe J, Rizzoli R, Saag K, Reginster JY.

Aging Clin Exp Res. 2016 Feb;28(1):1-16. doi: 10.1007/s40520-015-0522-1. Epub 2016 Jan 8.


Erosions in the foot at baseline are predictive of orthopaedic shoe use after 10 years of treat to target therapy in patients with recent onset rheumatoid arthritis.

Bergstra SA, Markusse IM, Akdemir G, Ronday HK, Han KH, Lems WF, Kerstens PJ, van den Berg R, Landewé RB, Allaart CF.

Clin Rheumatol. 2015 Dec 22. [Epub ahead of print]


Systemic lupus erythematosus and fractures.

Bultink IE, Lems WF.

RMD Open. 2015 Aug 15;1(Suppl 1):e000069. doi: 10.1136/rmdopen-2015-000069. eCollection 2015.


Glucocorticoids: bad or safe for the bones?

Lems WF.

RMD Open. 2015 Aug 15;1(Suppl 1):e000050. doi: 10.1136/rmdopen-2015-000050. eCollection 2015.


Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.

Verbrugge SE, Al M, Assaraf YG, Kammerer S, Chandrupatla DM, Honeywell R, Musters RP, Giovannetti E, O'Toole T, Scheffer GL, Krige D, de Gruijl TD, Niessen HW, Lems WF, Kramer PA, Scheper RJ, Cloos J, Ossenkoppele GJ, Peters GJ, Jansen G.

Oncotarget. 2015 Oct 19. doi: 10.18632/oncotarget.6169. [Epub ahead of print]


Fracture risk estimation may facilitate the treatment gap in osteoporosis.

Lems WF.

Ann Rheum Dis. 2015 Nov;74(11):1943-5. doi: 10.1136/annrheumdis-2015-208245. Epub 2015 Sep 25. No abstract available.


Subclinical synovitis detected by macrophage PET, but not MRI, is related to short-term flare of clinical disease activity in early RA patients: an exploratory study.

Gent YY, Ter Wee MM, Voskuyl AE, den Uyl D, Ahmadi N, Dowling C, van Kuijk C, Hoekstra OS, Boers M, Lems WF, van der Laken CJ.

Arthritis Res Ther. 2015 Sep 25;17:266. doi: 10.1186/s13075-015-0770-7.


Disease flares in rheumatoid arthritis are associated with joint damage progression and disability: 10-year results from the BeSt study.

Markusse IM, Dirven L, Gerards AH, van Groenendael JH, Ronday HK, Kerstens PJ, Lems WF, Huizinga TW, Allaart CF.

Arthritis Res Ther. 2015 Aug 31;17:232. doi: 10.1186/s13075-015-0730-2.


Prognosis of pain and physical functioning in patients with knee osteoarthritis: Systematic review and meta-analysis.

de Rooij M, van der Leeden M, Heymans MW, Holla JF, Häkkinen A, Lems WF, Roorda LD, Veenhof C, Sanchez-Ramirez DC, de Vet HC, Dekker J.

Arthritis Care Res (Hoboken). 2015 Aug 28. doi: 10.1002/acr.22693. [Epub ahead of print]


[Dose-reduction of TNF-α blockers in patients with rheumatoid arthritis].

Lems WF.

Ned Tijdschr Geneeskd. 2015;159:A9341. Dutch.


Optimization of analgesics allows patients with knee osteoarthritis and severe pain to participate in exercise therapy - a feasibility study.

van Tunen JA, van der Leeden M, Bos WH, Cheung J, van der Esch M, Gerritsen M, Peter WF, Roorda LD, Tijhuis GJ, Voorneman RE, Lems WF, Dekker J.

Arthritis Care Res (Hoboken). 2015 Aug 3. doi: 10.1002/acr.22682. [Epub ahead of print]


Evaluating adherence to a treat-to-target protocol in recent-onset rheumatoid arthritis: Reasons for compliance and hesitation.

Markusse IM, Dirven L, Han KH, Ronday HK, de Sonnaville PB, Kerstens PJ, Lems WF, Huizinga TW, Allaart CF.

Arthritis Care Res (Hoboken). 2015 Aug 3. doi: 10.1002/acr.22681. [Epub ahead of print]


Effective Treatment for Rapid Improvement of Both Disease Activity and Self-Reported Physical Activity in Early Rheumatoid Arthritis.

Konijn NP, van Tuyl LH, Boers M, den Uyl D, Ter Wee MM, Kerstens P, Voskuyl AE, Nurmohamed M, van Schaardenburg D, Lems WF.

Arthritis Care Res (Hoboken). 2016 Feb;68(2):280-4. doi: 10.1002/acr.22668.


Low grade inflammation is associated with lower velocity of sound and broadband ultrasound attenuation in older men, but not with bone loss or fracture risk in a longitudinal aging study.

den Uyl D, van Schoor NM, Bravenboer N, Lips P, Lems WF.

Bone. 2015 Dec;81:270-6. doi: 10.1016/j.bone.2015.07.017. Epub 2015 Jul 16.


Response to 'Feasibility of tailored treatment based on risk stratification in patients with early rheumatoid arthritis'--authors' reply.

Markusse IM, Lems WF, Huizinga TW, Allaart CF.

Arthritis Res Ther. 2015 Jul 2;17:171. doi: 10.1186/s13075-015-0681-7. No abstract available.


CXCL8 and CCL20 Enhance Osteoclastogenesis via Modulation of Cytokine Production by Human Primary Osteoblasts.

Pathak JL, Bakker AD, Verschueren P, Lems WF, Luyten FP, Klein-Nulend J, Bravenboer N.

PLoS One. 2015 Jun 23;10(6):e0131041. doi: 10.1371/journal.pone.0131041. eCollection 2015.


Increased knee muscle strength is associated with decreased activity limitations in established knee osteoarthritis: Two-year follow-up study in the Amsterdam osteoarthritis cohort.

Sanchez-Ramirez DC, van der Leeden M, van der Esch M, Roorda LD, Verschueren S, van Dieën J, Lems WF, Dekker J.

J Rehabil Med. 2015 Aug 18;47(7):647-54. doi: 10.2340/16501977-1973.


Bisphosphonates and glucocorticoid-induced osteoporosis: cons.

Lems WF, Saag K.

Endocrine. 2015 Aug;49(3):628-34. doi: 10.1007/s12020-015-0639-1. Epub 2015 Jun 4.


Mechanical loading reduces inflammation-induced human osteocyte-to-osteoclast communication.

Pathak JL, Bravenboer N, Luyten FP, Verschueren P, Lems WF, Klein-Nulend J, Bakker AD.

Calcif Tissue Int. 2015 Aug;97(2):169-78. doi: 10.1007/s00223-015-9999-z. Epub 2015 May 13.

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