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Results: 1 to 20 of 117

1.

The EGFR family: not so prototypical receptor tyrosine kinases.

Lemmon MA, Schlessinger J, Ferguson KM.

Cold Spring Harb Perspect Biol. 2014 Apr 1;6(4):a020768. doi: 10.1101/cshperspect.a020768.

PMID:
24691965
[PubMed - in process]
2.

Mechanism for activation of mutated epidermal growth factor receptors in lung cancer.

Red Brewer M, Yun CH, Lai D, Lemmon MA, Eck MJ, Pao W.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):E3595-604. doi: 10.1073/pnas.1220050110. Epub 2013 Sep 9. Erratum in: Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20344.

PMID:
24019492
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Receptor tyrosine kinases with intracellular pseudokinase domains.

Mendrola JM, Shi F, Park JH, Lemmon MA.

Biochem Soc Trans. 2013 Aug;41(4):1029-36. doi: 10.1042/BST20130104. Review.

PMID:
23863174
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain.

Park JH, Liu Y, Lemmon MA, Radhakrishnan R.

Biochem J. 2012 Dec 15;448(3):417-23. doi: 10.1042/BJ20121513.

PMID:
23101586
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family.

Artim SC, Mendrola JM, Lemmon MA.

Biochem J. 2012 Dec 1;448(2):213-20. doi: 10.1042/BJ20121365.

PMID:
22992069
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Occupy EGFR.

Park JH, Lemmon MA.

Cancer Discov. 2012 May;2(5):398-400. doi: 10.1158/2159-8290.CD-12-0144.

PMID:
22588876
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma.

Carpenter EL, Haglund EA, Mace EM, Deng D, Martinez D, Wood AC, Chow AK, Weiser DA, Belcastro LT, Winter C, Bresler SC, Vigny M, Mazot P, Asgharzadeh S, Seeger RC, Zhao H, Guo R, Christensen JG, Orange JS, Pawel BR, Lemmon MA, Mossé YP.

Oncogene. 2012 Nov 15;31(46):4859-67. doi: 10.1038/onc.2011.647. Epub 2012 Jan 23. Erratum in: Oncogene. 2012 Nov 15;31(46):4888. Vigny, M [added]; Mazot, P [added].

PMID:
22266870
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Finding the missing links in EGFR.

Bessman NJ, Lemmon MA.

Nat Struct Mol Biol. 2012 Jan 5;19(1):1-3. doi: 10.1038/nsmb.2221. No abstract available.

PMID:
22218287
[PubMed - indexed for MEDLINE]
9.

Conditional peripheral membrane proteins: facing up to limited specificity.

Moravcevic K, Oxley CL, Lemmon MA.

Structure. 2012 Jan 11;20(1):15-27. doi: 10.1016/j.str.2011.11.012. Epub 2011 Dec 21. Review.

PMID:
22193136
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma.

Bresler SC, Wood AC, Haglund EA, Courtright J, Belcastro LT, Plegaria JS, Cole K, Toporovskaya Y, Zhao H, Carpenter EL, Christensen JG, Maris JM, Lemmon MA, Mossé YP.

Sci Transl Med. 2011 Nov 9;3(108):108ra114. doi: 10.1126/scitranslmed.3002950.

PMID:
22072639
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic.

Watt B, Tenza D, Lemmon MA, Kerje S, Raposo G, Andersson L, Marks MS.

PLoS Genet. 2011 Sep;7(9):e1002286. doi: 10.1371/journal.pgen.1002286. Epub 2011 Sep 15.

PMID:
21949659
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Biochemistry. KSR plays CRAF-ty.

Shi F, Lemmon MA.

Science. 2011 May 27;332(6033):1043-4. doi: 10.1126/science.1208063. No abstract available.

PMID:
21617065
[PubMed - indexed for MEDLINE]
13.

Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases.

Shih AJ, Telesco SE, Choi SH, Lemmon MA, Radhakrishnan R.

Biochem J. 2011 Jun 1;436(2):241-51. doi: 10.1042/BJ20101791.

PMID:
21426301
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Protein kinase C regulation: C1 meets C-tail.

Kazanietz MG, Lemmon MA.

Structure. 2011 Feb 9;19(2):144-6. doi: 10.1016/j.str.2011.01.004.

PMID:
21300283
[PubMed]
Free Article
15.

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG.

Mol Cell. 2010 Dec 22;40(6):877-92. doi: 10.1016/j.molcel.2010.11.029.

PMID:
21172654
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids.

Moravcevic K, Mendrola JM, Schmitz KR, Wang YH, Slochower D, Janmey PA, Lemmon MA.

Cell. 2010 Dec 10;143(6):966-77. doi: 10.1016/j.cell.2010.11.028.

PMID:
21145462
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Structural basis for negative cooperativity in growth factor binding to an EGF receptor.

Alvarado D, Klein DE, Lemmon MA.

Cell. 2010 Aug 20;142(4):568-79. doi: 10.1016/j.cell.2010.07.015.

PMID:
20723758
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients.

Kenniston JA, Lemmon MA.

EMBO J. 2010 Sep 15;29(18):3054-67. doi: 10.1038/emboj.2010.187. Epub 2010 Aug 10.

PMID:
20700106
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Cell signaling by receptor tyrosine kinases.

Lemmon MA, Schlessinger J.

Cell. 2010 Jun 25;141(7):1117-34. doi: 10.1016/j.cell.2010.06.011. Review.

PMID:
20602996
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation.

Shi F, Telesco SE, Liu Y, Radhakrishnan R, Lemmon MA.

Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7692-7. doi: 10.1073/pnas.1002753107. Epub 2010 Mar 29.

PMID:
20351256
[PubMed - indexed for MEDLINE]
Free PMC Article

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