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Results: 1 to 20 of 122


Comparison of Saccharomyces cerevisiae F-BAR domain structures reveals a conserved inositol phosphate binding site.

Moravcevic K, Alvarado D, Schmitz KR, Kenniston JA, Mendrola JM, Ferguson KM, Lemmon MA.

Structure. 2015 Feb 3;23(2):352-63. doi: 10.1016/j.str.2014.12.009. Epub 2015 Jan 22.


ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma.

Bresler SC, Weiser DA, Huwe PJ, Park JH, Krytska K, Ryles H, Laudenslager M, Rappaport EF, Wood AC, McGrady PW, Hogarty MD, London WB, Radhakrishnan R, Lemmon MA, Mossé YP.

Cancer Cell. 2014 Nov 10;26(5):682-94. doi: 10.1016/j.ccell.2014.09.019. Epub 2014 Nov 10.


Putting together structures of epidermal growth factor receptors.

Bessman NJ, Freed DM, Lemmon MA.

Curr Opin Struct Biol. 2014 Dec;29:95-101. doi: 10.1016/ Epub 2014 Oct 24.


Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor.

Bessman NJ, Bagchi A, Ferguson KM, Lemmon MA.

Cell Rep. 2014 Nov 20;9(4):1306-17. doi: 10.1016/j.celrep.2014.10.010. Epub 2014 Nov 6.


TIPE3 is the transfer protein of lipid second messengers that promote cancer.

Fayngerts SA, Wu J, Oxley CL, Liu X, Vourekas A, Cathopoulis T, Wang Z, Cui J, Liu S, Sun H, Lemmon MA, Zhang L, Shi Y, Chen YH.

Cancer Cell. 2014 Oct 13;26(4):465-78. doi: 10.1016/j.ccr.2014.07.025. Epub 2014 Sep 18.


The EGFR family: not so prototypical receptor tyrosine kinases.

Lemmon MA, Schlessinger J, Ferguson KM.

Cold Spring Harb Perspect Biol. 2014 Apr 1;6(4):a020768. doi: 10.1101/cshperspect.a020768. Review.


Mechanism for activation of mutated epidermal growth factor receptors in lung cancer.

Red Brewer M, Yun CH, Lai D, Lemmon MA, Eck MJ, Pao W.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):E3595-604. doi: 10.1073/pnas.1220050110. Epub 2013 Sep 9. Erratum in: Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20344.


Receptor tyrosine kinases with intracellular pseudokinase domains.

Mendrola JM, Shi F, Park JH, Lemmon MA.

Biochem Soc Trans. 2013 Aug;41(4):1029-36. doi: 10.1042/BST20130104. Review.


Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain.

Park JH, Liu Y, Lemmon MA, Radhakrishnan R.

Biochem J. 2012 Dec 15;448(3):417-23. doi: 10.1042/BJ20121513.


Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family.

Artim SC, Mendrola JM, Lemmon MA.

Biochem J. 2012 Dec 1;448(2):213-20. doi: 10.1042/BJ20121365.


Occupy EGFR.

Park JH, Lemmon MA.

Cancer Discov. 2012 May;2(5):398-400. doi: 10.1158/2159-8290.CD-12-0144.


Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma.

Carpenter EL, Haglund EA, Mace EM, Deng D, Martinez D, Wood AC, Chow AK, Weiser DA, Belcastro LT, Winter C, Bresler SC, Vigny M, Mazot P, Asgharzadeh S, Seeger RC, Zhao H, Guo R, Christensen JG, Orange JS, Pawel BR, Lemmon MA, Mossé YP.

Oncogene. 2012 Nov 15;31(46):4859-67. doi: 10.1038/onc.2011.647. Epub 2012 Jan 23. Erratum in: Oncogene. 2012 Nov 15;31(46):4888. Vigny, M [added]; Mazot, P [added].


Finding the missing links in EGFR.

Bessman NJ, Lemmon MA.

Nat Struct Mol Biol. 2012 Jan 5;19(1):1-3. doi: 10.1038/nsmb.2221. No abstract available.


Conditional peripheral membrane proteins: facing up to limited specificity.

Moravcevic K, Oxley CL, Lemmon MA.

Structure. 2012 Jan 11;20(1):15-27. doi: 10.1016/j.str.2011.11.012. Epub 2011 Dec 21. Review.


Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma.

Bresler SC, Wood AC, Haglund EA, Courtright J, Belcastro LT, Plegaria JS, Cole K, Toporovskaya Y, Zhao H, Carpenter EL, Christensen JG, Maris JM, Lemmon MA, Mossé YP.

Sci Transl Med. 2011 Nov 9;3(108):108ra114. doi: 10.1126/scitranslmed.3002950.


Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic.

Watt B, Tenza D, Lemmon MA, Kerje S, Raposo G, Andersson L, Marks MS.

PLoS Genet. 2011 Sep;7(9):e1002286. doi: 10.1371/journal.pgen.1002286. Epub 2011 Sep 15.


Biochemistry. KSR plays CRAF-ty.

Shi F, Lemmon MA.

Science. 2011 May 27;332(6033):1043-4. doi: 10.1126/science.1208063. No abstract available.


Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases.

Shih AJ, Telesco SE, Choi SH, Lemmon MA, Radhakrishnan R.

Biochem J. 2011 Jun 1;436(2):241-51. doi: 10.1042/BJ20101791.


Protein kinase C regulation: C1 meets C-tail.

Kazanietz MG, Lemmon MA.

Structure. 2011 Feb 9;19(2):144-6. doi: 10.1016/j.str.2011.01.004.


Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG.

Mol Cell. 2010 Dec 22;40(6):877-92. doi: 10.1016/j.molcel.2010.11.029.

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