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Results: 1 to 20 of 596

1.

Multiple haplotype-resolved genomes reveal population patterns of gene and protein diplotypes.

Hoehe MR, Church GM, Lehrach H, Kroslak T, Palczewski S, Nowick K, Schulz S, Suk EK, Huebsch T.

Nat Commun. 2014 Nov 26;5:5569. doi: 10.1038/ncomms6569.

PMID:
25424553
[PubMed - in process]
Free PMC Article
2.

Comparative analysis and modeling of the severity of steatohepatitis in DDC-treated mouse strains.

Pandey V, Sultan M, Kashofer K, Ralser M, Amstislavskiy V, Starmann J, Osprian I, Grimm C, Hache H, Yaspo ML, Sültmann H, Trauner M, Denk H, Zatloukal K, Lehrach H, Wierling C.

PLoS One. 2014 Oct 27;9(10):e111006. doi: 10.1371/journal.pone.0111006. eCollection 2014.

PMID:
25347188
[PubMed - in process]
Free PMC Article
3.

Influence of RNA extraction methods and library selection schemes on RNA-seq data.

Sultan M, Amstislavskiy V, Risch T, Schuette M, Dökel S, Ralser M, Balzereit D, Lehrach H, Yaspo ML.

BMC Genomics. 2014 Aug 11;15:675. doi: 10.1186/1471-2164-15-675.

PMID:
25113896
[PubMed - in process]
Free PMC Article
4.

Personalized medicine approaches for colon cancer driven by genomics and systems biology: OncoTrack.

Henderson D, Ogilvie LA, Hoyle N, Keilholz U, Lange B, Lehrach H; OncoTrack Consortium.

Biotechnol J. 2014 Sep;9(9):1104-14. doi: 10.1002/biot.201400109. Epub 2014 Jul 29.

PMID:
25074435
[PubMed - in process]
Free Article
5.

Exome sequencing from nanogram amounts of starting DNA: comparing three approaches.

Rykalina VN, Shadrin AA, Amstislavskiy VS, Rogaev EI, Lehrach H, Borodina TA.

PLoS One. 2014 Jul 3;9(7):e101154. doi: 10.1371/journal.pone.0101154. eCollection 2014.

PMID:
24992588
[PubMed - in process]
Free PMC Article
6.

ARH-seq: identification of differential splicing in RNA-seq data.

Rasche A, Lienhard M, Yaspo ML, Lehrach H, Herwig R.

Nucleic Acids Res. 2014;42(14):e110. doi: 10.1093/nar/gku495. Epub 2014 Jun 11.

PMID:
24920826
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing.

Hovestadt V, Jones DT, Picelli S, Wang W, Kool M, Northcott PA, Sultan M, Stachurski K, Ryzhova M, Warnatz HJ, Ralser M, Brun S, Bunt J, Jäger N, Kleinheinz K, Erkek S, Weber UD, Bartholomae CC, von Kalle C, Lawerenz C, Eils J, Koster J, Versteeg R, Milde T, Witt O, Schmidt S, Wolf S, Pietsch T, Rutkowski S, Scheurlen W, Taylor MD, Brors B, Felsberg J, Reifenberger G, Borkhardt A, Lehrach H, Wechsler-Reya RJ, Eils R, Yaspo ML, Landgraf P, Korshunov A, Zapatka M, Radlwimmer B, Pfister SM, Lichter P.

Nature. 2014 Jun 26;510(7506):537-41. doi: 10.1038/nature13268. Epub 2014 May 18.

PMID:
24847876
[PubMed - indexed for MEDLINE]
8.

Parallel profiling of the transcriptome, cistrome, and epigenome in the cellular response to ionizing radiation.

Rashi-Elkeles S, Warnatz HJ, Elkon R, Kupershtein A, Chobod Y, Paz A, Amstislavskiy V, Sultan M, Safer H, Nietfeld W, Lehrach H, Shamir R, Yaspo ML, Shiloh Y.

Sci Signal. 2014 May 13;7(325):rs3. doi: 10.1126/scisignal.2005032.

PMID:
24825921
[PubMed - in process]
9.

The nerve growth factor receptor CD271 is crucial to maintain tumorigenicity and stem-like properties of melanoma cells.

Redmer T, Welte Y, Behrens D, Fichtner I, Przybilla D, Wruck W, Yaspo ML, Lehrach H, Schäfer R, Regenbrecht CR.

PLoS One. 2014 May 5;9(5):e92596. doi: 10.1371/journal.pone.0092596. eCollection 2014.

PMID:
24799129
[PubMed - in process]
Free PMC Article
10.

The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response.

Hussong M, Börno ST, Kerick M, Wunderlich A, Franz A, Sültmann H, Timmermann B, Lehrach H, Hirsch-Kauffmann M, Schweiger MR.

Cell Death Dis. 2014 Apr 24;5:e1195. doi: 10.1038/cddis.2014.157.

PMID:
24763052
[PubMed - in process]
Free PMC Article
11.

5-Fluorouracil affects assembly of stress granules based on RNA incorporation.

Kaehler C, Isensee J, Hucho T, Lehrach H, Krobitsch S.

Nucleic Acids Res. 2014;42(10):6436-47. doi: 10.1093/nar/gku264. Epub 2014 Apr 11.

PMID:
24728989
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The genome of the recently domesticated crop plant sugar beet (Beta vulgaris).

Dohm JC, Minoche AE, Holtgräwe D, Capella-Gutiérrez S, Zakrzewski F, Tafer H, Rupp O, Sörensen TR, Stracke R, Reinhardt R, Goesmann A, Kraft T, Schulz B, Stadler PF, Schmidt T, Gabaldón T, Lehrach H, Weisshaar B, Himmelbauer H.

Nature. 2014 Jan 23;505(7484):546-9. doi: 10.1038/nature12817. Epub 2013 Dec 18.

PMID:
24352233
[PubMed - indexed for MEDLINE]
13.

Hypermutation of the inactive X chromosome is a frequent event in cancer.

Jäger N, Schlesner M, Jones DT, Raffel S, Mallm JP, Junge KM, Weichenhan D, Bauer T, Ishaque N, Kool M, Northcott PA, Korshunov A, Drews RM, Koster J, Versteeg R, Richter J, Hummel M, Mack SC, Taylor MD, Witt H, Swartman B, Schulte-Bockholt D, Sultan M, Yaspo ML, Lehrach H, Hutter B, Brors B, Wolf S, Plass C, Siebert R, Trumpp A, Rippe K, Lehmann I, Lichter P, Pfister SM, Eils R.

Cell. 2013 Oct 24;155(3):567-81. doi: 10.1016/j.cell.2013.09.042. Epub 2013 Oct 17.

PMID:
24139898
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

BMP10 as a potent inducer of trophoblast differentiation in human embryonic and induced pluripotent stem cells.

Lichtner B, Knaus P, Lehrach H, Adjaye J.

Biomaterials. 2013 Dec;34(38):9789-802. doi: 10.1016/j.biomaterials.2013.08.084. Epub 2013 Sep 23.

PMID:
24070570
[PubMed - indexed for MEDLINE]
15.

DNA sequencing methods in human genetics and disease research.

Lehrach H.

F1000Prime Rep. 2013 Sep 2;5:34. doi: 10.12703/P5-34. Review.

PMID:
24049638
[PubMed]
Free PMC Article
16.

Transcriptome and genome sequencing uncovers functional variation in humans.

Lappalainen T, Sammeth M, Friedländer MR, 't Hoen PA, Monlong J, Rivas MA, Gonzàlez-Porta M, Kurbatova N, Griebel T, Ferreira PG, Barann M, Wieland T, Greger L, van Iterson M, Almlöf J, Ribeca P, Pulyakhina I, Esser D, Giger T, Tikhonov A, Sultan M, Bertier G, MacArthur DG, Lek M, Lizano E, Buermans HP, Padioleau I, Schwarzmayr T, Karlberg O, Ongen H, Kilpinen H, Beltran S, Gut M, Kahlem K, Amstislavskiy V, Stegle O, Pirinen M, Montgomery SB, Donnelly P, McCarthy MI, Flicek P, Strom TM; Geuvadis Consortium, Lehrach H, Schreiber S, Sudbrak R, Carracedo A, Antonarakis SE, Häsler R, Syvänen AC, van Ommen GJ, Brazma A, Meitinger T, Rosenstiel P, Guigó R, Gut IG, Estivill X, Dermitzakis ET.

Nature. 2013 Sep 26;501(7468):506-11. doi: 10.1038/nature12531. Epub 2013 Sep 15.

PMID:
24037378
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

High-throughput miRNA and mRNA sequencing of paired colorectal normal, tumor and metastasis tissues and bioinformatic modeling of miRNA-1 therapeutic applications.

Röhr C, Kerick M, Fischer A, Kühn A, Kashofer K, Timmermann B, Daskalaki A, Meinel T, Drichel D, Börno ST, Nowka A, Krobitsch S, McHardy AC, Kratsch C, Becker T, Wunderlich A, Barmeyer C, Viertler C, Zatloukal K, Wierling C, Lehrach H, Schweiger MR.

PLoS One. 2013 Jul 2;8(7):e67461. doi: 10.1371/journal.pone.0067461. Print 2013.

PMID:
23874421
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Fkh1 and Fkh2 associate with Sir2 to control CLB2 transcription under normal and oxidative stress conditions.

Linke C, Klipp E, Lehrach H, Barberis M, Krobitsch S.

Front Physiol. 2013 Jul 12;4:173. doi: 10.3389/fphys.2013.00173. eCollection 2013.

PMID:
23874301
[PubMed]
Free PMC Article
19.

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P, Pfister SM; International Cancer Genome Consortium PedBrain Tumor Project.

Nat Genet. 2013 Aug;45(8):927-32. doi: 10.1038/ng.2682. Epub 2013 Jun 30.

PMID:
23817572
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.

Götschel F, Berg D, Gruber W, Bender C, Eberl M, Friedel M, Sonntag J, Rüngeler E, Hache H, Wierling C, Nietfeld W, Lehrach H, Frischauf A, Schwartz-Albiez R, Aberger F, Korf U.

PLoS One. 2013 Jun 10;8(6):e65403. doi: 10.1371/journal.pone.0065403. Print 2013.

PMID:
23762360
[PubMed - indexed for MEDLINE]
Free PMC Article

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