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Burkholderia genome mining for nonribosomal peptide synthetases reveals a great potential for novel siderophores and lipopeptides synthesis.

Esmaeel Q, Pupin M, Kieu NP, Chataigné G, Béchet M, Deravel J, Krier F, Höfte M, Jacques P, Leclère V.

Microbiologyopen. 2016 Jun;5(3):512-26. doi: 10.1002/mbo3.347. Epub 2016 Apr 5.


The cyclochlorotine mycotoxin is produced by the nonribosomal peptide synthetase CctN in Talaromyces islandicus ("Penicillium islandicum").

Schafhauser T, Kirchner N, Kulik A, Huijbers MM, Flor L, Caradec T, Fewer DP, Gross H, Jacques P, Jahn L, Jokela J, Leclère V, Ludwig-Müller J, Sivonen K, van Berkel WJ, Weber T, Wohlleben W, van Pée KH.

Environ Microbiol. 2016 Mar 8. doi: 10.1111/1462-2920.13294. [Epub ahead of print]


Bioinformatics Tools for the Discovery of New Nonribosomal Peptides.

Leclère V, Weber T, Jacques P, Pupin M.

Methods Mol Biol. 2016;1401:209-32. doi: 10.1007/978-1-4939-3375-4_14.


Smiles2Monomers: a link between chemical and biological structures for polymers.

Dufresne Y, Noé L, Leclère V, Pupin M.

J Cheminform. 2015 Dec 29;7:62. doi: 10.1186/s13321-015-0111-5. eCollection 2015.


Norine, the knowledgebase dedicated to non-ribosomal peptides, is now open to crowdsourcing.

Flissi A, Dufresne Y, Michalik J, Tonon L, Janot S, Noé L, Jacques P, Leclère V, Pupin M.

Nucleic Acids Res. 2016 Jan 4;44(D1):D1113-8. doi: 10.1093/nar/gkv1143. Epub 2015 Nov 2.


Characterization of Cichopeptins, New Phytotoxic Cyclic Lipodepsipeptides Produced by Pseudomonas cichorii SF1-54 and Their Role in Bacterial Midrib Rot Disease of Lettuce.

Huang CJ, Pauwelyn E, Ongena M, Debois D, Leclère V, Jacques P, Bleyaert P, Höfte M.

Mol Plant Microbe Interact. 2015 Sep;28(9):1009-22. doi: 10.1094/MPMI-03-15-0061-R. Epub 2015 Aug 10.


To settle or to move? The interplay between two classes of cyclic lipopeptides in the biocontrol strain Pseudomonas CMR12a.

D'aes J, Kieu NP, Léclère V, Tokarski C, Olorunleke FE, De Maeyer K, Jacques P, Höfte M, Ongena M.

Environ Microbiol. 2014 Jul;16(7):2282-300. doi: 10.1111/1462-2920.12462. Epub 2014 Apr 28.


Prediction of monomer isomery in Florine: a workflow dedicated to nonribosomal peptide discovery.

Caradec T, Pupin M, Vanvlassenbroeck A, Devignes MD, Smaïl-Tabbone M, Jacques P, Leclère V.

PLoS One. 2014 Jan 21;9(1):e85667. doi: 10.1371/journal.pone.0085667. eCollection 2014.


Prediction of new bioactive molecules using a Bayesian belief network.

Abdo A, Leclère V, Jacques P, Salim N, Pupin M.

J Chem Inf Model. 2014 Jan 27;54(1):30-6. doi: 10.1021/ci4004909. Epub 2014 Jan 15.


Production of a novel mixture of mycosubtilins by mutants of Bacillus subtilis.

Béchet M, Castéra-Guy J, Guez JS, Chihib NE, Coucheney F, Coutte F, Fickers P, Leclère V, Wathelet B, Jacques P.

Bioresour Technol. 2013 Oct;145:264-70. doi: 10.1016/j.biortech.2013.03.123. Epub 2013 Mar 26.


New linear lipopeptides produced by Pseudomonas cichorii SF1-54 are involved in virulence, swarming motility, and biofilm formation.

Pauwelyn E, Huang CJ, Ongena M, Leclère V, Jacques P, Bleyaert P, Budzikiewicz H, Schäfer M, Höfte M.

Mol Plant Microbe Interact. 2013 May;26(5):585-98. doi: 10.1094/MPMI-11-12-0258-R.


A new fingerprint to predict nonribosomal peptides activity.

Abdo A, Caboche S, Leclère V, Jacques P, Pupin M.

J Comput Aided Mol Des. 2012 Oct;26(10):1187-94. doi: 10.1007/s10822-012-9608-4. Epub 2012 Sep 29.


Effect of oseltamivir, zanamivir or oseltamivir-zanamivir combination treatments on transmission of influenza in households.

Carrat F, Duval X, Tubach F, Mosnier A, Van der Werf S, Tibi A, Blanchon T, Leport C, Flahault A, Mentré F; BIVIR study group.

Antivir Ther. 2012;17(6):1085-90. doi: 10.3851/IMP2128. Epub 2012 Jun 7.


Structure, biosynthesis, and properties of kurstakins, nonribosomal lipopeptides from Bacillus spp.

Béchet M, Caradec T, Hussein W, Abderrahmani A, Chollet M, Leclère V, Dubois T, Lereclus D, Pupin M, Jacques P.

Appl Microbiol Biotechnol. 2012 Aug;95(3):593-600. doi: 10.1007/s00253-012-4181-2. Epub 2012 Jun 9. Review.


Factors associated with clinical and virological response in patients treated with oseltamivir or zanamivir for influenza A during the 2008-2009 winter.

Blanchon T, Mentré F, Charlois-Ou C, Dornic Q, Mosnier A, Bouscambert M, Carrat F, Duval X, Enouf V, Leport C; Bivir Study Group.

Clin Microbiol Infect. 2013 Feb;19(2):196-203. doi: 10.1111/j.1469-0691.2011.03751.x. Epub 2012 Jan 20.


Bioinformatics and molecular approaches to detect NRPS genes involved in the biosynthesis of kurstakin from Bacillus thuringiensis.

Abderrahmani A, Tapi A, Nateche F, Chollet M, Leclère V, Wathelet B, Hacene H, Jacques P.

Appl Microbiol Biotechnol. 2011 Nov;92(3):571-81. doi: 10.1007/s00253-011-3453-6. Epub 2011 Jul 13.


Efficacy of oseltamivir-zanamivir combination compared to each monotherapy for seasonal influenza: a randomized placebo-controlled trial.

Duval X, van der Werf S, Blanchon T, Mosnier A, Bouscambert-Duchamp M, Tibi A, Enouf V, Charlois-Ou C, Vincent C, Andreoletti L, Tubach F, Lina B, Mentré F, Leport C; Bivir Study Group.

PLoS Med. 2010 Nov 2;7(11):e1000362. doi: 10.1371/journal.pmed.1000362. Erratum in: PLoS Med. 2010;7(12) doi: 10.1371/annotation/ca448e7c-fbbc-43e9-9981-108c9bfa8bce.


Diversity of monomers in nonribosomal peptides: towards the prediction of origin and biological activity.

Caboche S, Leclère V, Pupin M, Kucherov G, Jacques P.

J Bacteriol. 2010 Oct;192(19):5143-50. doi: 10.1128/JB.00315-10. Epub 2010 Aug 6.


Production of surfactin and fengycin by Bacillus subtilis in a bubbleless membrane bioreactor.

Coutte F, Lecouturier D, Yahia SA, Leclère V, Béchet M, Jacques P, Dhulster P.

Appl Microbiol Biotechnol. 2010 Jun;87(2):499-507. doi: 10.1007/s00253-010-2504-8. Epub 2010 Mar 11.


Effect of pps disruption and constitutive expression of srfA on surfactin productivity, spreading and antagonistic properties of Bacillus subtilis 168 derivatives.

Coutte F, Leclère V, Béchet M, Guez JS, Lecouturier D, Chollet-Imbert M, Dhulster P, Jacques P.

J Appl Microbiol. 2010 Aug;109(2):480-91. doi: 10.1111/j.1365-2672.2010.04683.x. Epub 2010 Jan 22.

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