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The Achilles' Heel of Senescent Cells: From Transcriptome to Senolytic Drugs.

Zhu Y, Tchkonia T, Pirtskhalava T, Gower A, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Borden G, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL.

Aging Cell. 2015 Mar 9. doi: 10.1111/acel.12344. [Epub ahead of print]


Conditional deletion of Hdac3 in osteoprogenitor cells attenuates diet-induced systemic metabolic dysfunction.

McGee-Lawrence ME, White TA, LeBrasseur NK, Westendorf JJ.

Mol Cell Endocrinol. 2015 Feb 7. pii: S0303-7207(15)00068-4. doi: 10.1016/j.mce.2015.02.001. [Epub ahead of print] Review.


Shear wave elastography of passive skeletal muscle stiffness: influences of sex and age throughout adulthood.

Eby SF, Cloud BA, Brandenburg JE, Giambini H, Song P, Chen S, LeBrasseur NK, An KN.

Clin Biomech (Bristol, Avon). 2015 Jan;30(1):22-7. doi: 10.1016/j.clinbiomech.2014.11.011. Epub 2014 Nov 29.


TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess.

Idrissova L, Malhi H, Werneburg NW, LeBrasseur NK, Bronk SF, Fingas C, Tchkonia T, Pirtskhalava T, White TA, Stout MB, Hirsova P, Krishnan A, Liedtke C, Trautwein C, Finnberg N, El-Deiry WS, Kirkland JL, Gores GJ.

J Hepatol. 2014 Nov 28. pii: S0168-8278(14)00882-4. doi: 10.1016/j.jhep.2014.11.033. [Epub ahead of print]


Body composition during childhood and adolescence: relations to bone strength and microstructure.

Farr JN, Amin S, LeBrasseur NK, Atkinson EJ, Achenbach SJ, McCready LK, Joseph Melton L 3rd, Khosla S.

J Clin Endocrinol Metab. 2014 Dec;99(12):4641-8. doi: 10.1210/jc.2014-1113.


Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.

Stout MB, Tchkonia T, Pirtskhalava T, Palmer AK, List EO, Berryman DE, Lubbers ER, Escande C, Spong A, Masternak MM, Oberg AL, LeBrasseur NK, Miller RA, Kopchick JJ, Bartke A, Kirkland JL.

Aging (Albany NY). 2014 Jul;6(7):575-86.


Physiologic and metabolic safety of butyrylcholinesterase gene therapy in mice.

Murthy V, Gao Y, Geng L, LeBrasseur NK, White TA, Parks RJ, Brimijoin S.

Vaccine. 2014 Jul 16;32(33):4155-62. doi: 10.1016/j.vaccine.2014.05.067. Epub 2014 Jun 2.


Regenerating skeletal muscle in the face of aging and disease.

Jasuja R, LeBrasseur NK.

Am J Phys Med Rehabil. 2014 Nov;93(11 Suppl 3):S88-96. doi: 10.1097/PHM.0000000000000118. Review.


Determinants of gait speed in COPD.

Karpman C, DePew ZS, LeBrasseur NK, Novotny PJ, Benzo RP.

Chest. 2014 Jul;146(1):104-10. doi: 10.1378/chest.13-2017.


Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles.

List EO, Berryman DE, Funk K, Jara A, Kelder B, Wang F, Stout MB, Zhi X, Sun L, White TA, LeBrasseur NK, Pirtskhalava T, Tchkonia T, Jensen EA, Zhang W, Masternak MM, Kirkland JL, Miller RA, Bartke A, Kopchick JJ.

Endocrinology. 2014 May;155(5):1793-805. doi: 10.1210/en.2013-2086. Epub 2014 Feb 11.


Myostatin and sarcopenia: opportunities and challenges - a mini-review.

White TA, LeBrasseur NK.

Gerontology. 2014;60(4):289-93. doi: 10.1159/000356740. Epub 2014 Jan 17.


Preclinical studies on neurobehavioral and neuromuscular effects of cocaine hydrolase gene therapy in mice.

Murthy V, Gao Y, Geng L, LeBrasseur N, White T, Brimijoin S.

J Mol Neurosci. 2014 Jul;53(3):409-16. doi: 10.1007/s12031-013-0130-5. Epub 2013 Oct 2.


Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism.

Akasaki Y, Ouchi N, Izumiya Y, Bernardo BL, Lebrasseur NK, Walsh K.

Aging Cell. 2014 Feb;13(1):80-91. doi: 10.1111/acel.12153. Epub 2013 Sep 17.


Measuring gait speed in the out-patient clinic: methodology and feasibility.

Karpman C, Lebrasseur NK, Depew ZS, Novotny PJ, Benzo RP.

Respir Care. 2014 Apr;59(4):531-7. doi: 10.4187/respcare.02688. Epub 2013 Aug 27.


Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet.

Lanza IR, Blachnio-Zabielska A, Johnson ML, Schimke JM, Jakaitis DR, Lebrasseur NK, Jensen MD, Sreekumaran Nair K, Zabielski P.

Am J Physiol Endocrinol Metab. 2013 Jun 15;304(12):E1391-403. doi: 10.1152/ajpendo.00584.2012. Epub 2013 Apr 30. Erratum in: Am J Physiol Endocrinol Metab. 2013 Oct 15;305(8):E1048.


The A2b adenosine receptor modulates glucose homeostasis and obesity.

Johnston-Cox H, Koupenova M, Yang D, Corkey B, Gokce N, Farb MG, LeBrasseur N, Ravid K.

PLoS One. 2012;7(7):e40584. doi: 10.1371/journal.pone.0040584. Epub 2012 Jul 25.


Skeletal muscle mass is associated with bone geometry and microstructure and serum insulin-like growth factor binding protein-2 levels in adult women and men.

Lebrasseur NK, Achenbach SJ, Melton LJ 3rd, Amin S, Khosla S.

J Bone Miner Res. 2012 Oct;27(10):2159-69. doi: 10.1002/jbmr.1666.


Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.

Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM.

Nature. 2011 Nov 2;479(7372):232-6. doi: 10.1038/nature10600.


Substitution at carbon 2 of 19-nor-1α,25-dihydroxyvitamin D3 with 3-hydroxypropyl group generates an analogue with enhanced chemotherapeutic potency in PC-3 prostate cancer cells.

Iglesias-Gato D, Zheng S, Flanagan JN, Jiang L, Kittaka A, Sakaki T, Yamamoto K, Itoh T, Lebrasseur NK, Norstedt G, Chen TC.

J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):269-75. doi: 10.1016/j.jsbmb.2011.08.010. Epub 2011 Sep 3.


Acute exercise activates AMPK and eNOS in the mouse aorta.

Cacicedo JM, Gauthier MS, Lebrasseur NK, Jasuja R, Ruderman NB, Ido Y.

Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1255-65. doi: 10.1152/ajpheart.01279.2010. Epub 2011 Jul 1.

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