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Results: 1 to 20 of 295

1.

Deletion of Ptp4a3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice.

Cramer JM, Zimmerman MW, Thompson T, Homanics GE, Lazo JS, Lagasse E.

Stem Cell Res. 2014 Jul;13(1):164-71. doi: 10.1016/j.scr.2014.05.004. Epub 2014 May 27.

PMID:
24950307
[PubMed - in process]
Free Article
2.

Investigational inhibitors of PTP4A3 phosphatase as antineoplastic agents.

Sharlow ER, Wipf P, McQueeney KE, Bakan A, Lazo JS.

Expert Opin Investig Drugs. 2014 May;23(5):661-73. doi: 10.1517/13543784.2014.892579. Epub 2014 Mar 13.

PMID:
24625356
[PubMed - in process]
3.

Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility.

Zimmerman MW, McQueeney KE, Isenberg JS, Pitt BR, Wasserloos KA, Homanics GE, Lazo JS.

J Biol Chem. 2014 Feb 28;289(9):5904-13. doi: 10.1074/jbc.M113.480038. Epub 2014 Jan 8.

PMID:
24403062
[PubMed - indexed for MEDLINE]
4.

Auranofin is an apoptosis-simulating agent with in vitro and in vivo anti-leishmanial activity.

Sharlow ER, Leimgruber S, Murray S, Lira A, Sciotti RJ, Hickman M, Hudson T, Leed S, Caridha D, Barrios AM, Close D, Grögl M, Lazo JS.

ACS Chem Biol. 2014 Mar 21;9(3):663-72. doi: 10.1021/cb400800q. Epub 2013 Dec 23.

PMID:
24328400
[PubMed - in process]
5.

High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines.

Johnston PA, Sen M, Hua Y, Camarco D, Shun TY, Lazo JS, Grandis JR.

Assay Drug Dev Technol. 2014 Jan-Feb;12(1):55-79. doi: 10.1089/adt.2013.524. Epub 2013 Oct 15.

PMID:
24127660
[PubMed - in process]
6.

Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell death.

Lazo JS, Sharlow ER, Epperly MW, Lira A, Leimgruber S, Skoda EM, Wipf P, Greenberger JS.

J Pharmacol Exp Ther. 2013 Dec;347(3):669-80. doi: 10.1124/jpet.113.208421. Epub 2013 Sep 25.

PMID:
24068833
[PubMed - indexed for MEDLINE]
7.

Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells.

Goff JP, Shields DS, Wang H, Skoda EM, Sprachman MM, Wipf P, Garapati VK, Atkinson J, London B, Lazo JS, Kagan V, Epperly MW, Greenberger JS.

Exp Hematol. 2013 Nov;41(11):957-66. doi: 10.1016/j.exphem.2013.08.001. Epub 2013 Aug 7.

PMID:
23933481
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer.

Zimmerman MW, Homanics GE, Lazo JS.

PLoS One. 2013;8(3):e58300. doi: 10.1371/journal.pone.0058300. Epub 2013 Mar 28.

PMID:
23555575
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Drug discovery algorithm for cutaneous leishmaniasis.

Grogl M, Hickman M, Ellis W, Hudson T, Lazo JS, Sharlow ER, Johnson J, Berman J, Sciotti RJ.

Am J Trop Med Hyg. 2013 Feb;88(2):216-21. doi: 10.4269/ajtmh.11-0812. Review.

PMID:
23390221
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity.

Emert-Sedlak LA, Narute P, Shu ST, Poe JA, Shi H, Yanamala N, Alvarado JJ, Lazo JS, Yeh JI, Johnston PA, Smithgall TE.

Chem Biol. 2013 Jan 24;20(1):82-91. doi: 10.1016/j.chembiol.2012.11.005.

PMID:
23352142
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Alkylation sensitivity screens reveal a conserved cross-species functionome.

Svilar D, Dyavaiah M, Brown AR, Tang JB, Li J, McDonald PR, Shun TY, Braganza A, Wang XH, Maniar S, St Croix CM, Lazo JS, Pollack IF, Begley TJ, Sobol RW.

Mol Cancer Res. 2012 Dec;10(12):1580-96. doi: 10.1158/1541-7786.MCR-12-0168. Epub 2012 Oct 4.

PMID:
23038810
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Phenotypic screening reveals topoisomerase I as a breast cancer stem cell therapeutic target.

Zhang F, Rothermund K, Gangadharan SB, Pommier Y, Prochownik EV, Lazo JS.

Oncotarget. 2012 Sep;3(9):998-1010.

PMID:
22948175
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Targeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype.

McInnes C, Estes K, Baxter M, Yang Z, Farag DB, Johnston P, Lazo JS, Wang J, Wyatt MD.

Mol Cancer Ther. 2012 Aug;11(8):1683-92. doi: 10.1158/1535-7163.MCT-12-0006-T. Epub 2012 Jul 30.

PMID:
22848093
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Development and validation of a high-content screening assay to identify inhibitors of cytoplasmic dynein-mediated transport of glucocorticoid receptor to the nucleus.

Johnston PA, Shinde SN, Hua Y, Shun TY, Lazo JS, Day BW.

Assay Drug Dev Technol. 2012 Oct;10(5):432-56. doi: 10.1089/adt.2012.456. Epub 2012 Jul 25.

PMID:
22830992
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Identification of druggable targets for radiation mitigation using a small interfering RNA screening assay.

Zellefrow CD, Sharlow ER, Epperly MW, Reese CE, Shun T, Lira A, Greenberger JS, Lazo JS.

Radiat Res. 2012 Sep;178(3):150-9. Epub 2012 Jul 2.

PMID:
22747550
[PubMed - indexed for MEDLINE]
16.

Design, Synthesis, and Biological Evaluation of PKD Inhibitors.

George KM, Frantz MC, Bravo-Altamirano K, Lavalle CR, Tandon M, Leimgruber S, Sharlow ER, Lazo JS, Wang QJ, Wipf P.

Pharmaceutics. 2011;3(2):186-228. doi: 10.3390/pharmaceutics3020186.

PMID:
22267986
[PubMed]
Free PMC Article
17.

Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity.

Sharlow ER, Mustata Wilson G, Close D, Leimgruber S, Tandon M, Reed RB, Shun TY, Wang QJ, Wipf P, Lazo JS.

PLoS One. 2011;6(10):e25134. doi: 10.1371/journal.pone.0025134. Epub 2011 Oct 5.

PMID:
21998636
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Identification of Inhibitors of Trypanosoma brucei Hexokinases.

Sharlow E, Golden JE, Dodson H, Morris M, Hesser M, Lyda T, Leimgruber S, Schroeder CE, Flaherty DP, Weiner WS, Simpson D, Lazo JS, Aubé J, Morris JC.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Dec 15 [updated 2011 Jun 24].

PMID:
21961120
[PubMed]
Books & Documents
19.

Identification of chemosensitivity nodes for vinblastine through small interfering RNA high-throughput screens.

Kitchens CA, McDonald PR, Shun TY, Pollack IF, Lazo JS.

J Pharmacol Exp Ther. 2011 Dec;339(3):851-8. doi: 10.1124/jpet.111.184879. Epub 2011 Aug 31.

PMID:
21880871
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion.

Wang Y, Lazo JS.

Oncogene. 2012 Feb 16;31(7):818-27. doi: 10.1038/onc.2011.281. Epub 2011 Jul 18.

PMID:
21765462
[PubMed - indexed for MEDLINE]

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