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Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production.

Ip B, Cilfone NA, Belkina AC, DeFuria J, Jagannathan-Bogdan M, Zhu M, Kuchibhatla R, McDonnell ME, Xiao Q, Kepler TB, Apovian CM, Lauffenburger DA, Nikolajczyk BS.

Obesity (Silver Spring). 2015 Nov 18. doi: 10.1002/oby.21243. [Epub ahead of print]


Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening.

Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM.

Sci Rep. 2015 Nov 13;5:16622. doi: 10.1038/srep16622.


Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology.

Chung AW, Kumar MP, Arnold KB, Yu WH, Schoen MK, Dunphy LJ, Suscovich TJ, Frahm N, Linde C, Mahan AE, Hoffner M, Streeck H, Ackerman ME, McElrath MJ, Schuitemaker H, Pau MG, Baden LR, Kim JH, Michael NL, Barouch DH, Lauffenburger DA, Alter G.

Cell. 2015 Nov 5;163(4):988-98. doi: 10.1016/j.cell.2015.10.027.


Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration.

Yu J, Cilfone NA, Large EM, Sarkar U, Wishnok JS, Tannenbaum SR, Hughes DJ, Lauffenburger DA, Griffith LG, Stokes CL, Cirit M.

CPT Pharmacometrics Syst Pharmacol. 2015 Oct;4(10):585-94. doi: 10.1002/psp4.12010. Epub 2015 Oct 5.


Physiome-on-a-Chip: The Challenge of "Scaling" in Design, Operation, and Translation of Microphysiological Systems.

Stokes CL, Cirit M, Lauffenburger DA.

CPT Pharmacometrics Syst Pharmacol. 2015 Oct;4(10):559-62. doi: 10.1002/psp4.12042. Epub 2015 Oct 10.


Inflammatory cytokine biomarkers to identify women with asymptomatic sexually transmitted infections and bacterial vaginosis who are at high risk of HIV infection.

Masson L, Arnold KB, Little F, Mlisana K, Lewis DA, Mkhize N, Gamieldien H, Ngcapu S, Johnson L, Lauffenburger DA, Abdool Karim Q, Abdool Karim SS, Passmore JS.

Sex Transm Infect. 2015 Oct 28. pii: sextrans-2015-052072. doi: 10.1136/sextrans-2015-052072. [Epub ahead of print]


CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals.

Arnold KB, Szeto GL, Alter G, Irvine DJ, Lauffenburger DA.

Sci Signal. 2015 Oct 20;8(399):ra104. doi: 10.1126/scisignal.aab0808.


Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain.

Miller MA, Moss ML, Powell G, Petrovich R, Edwards L, Meyer AS, Griffith LG, Lauffenburger DA.

Sci Rep. 2015 Oct 19;5:15150. doi: 10.1038/srep15150.


PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.

Hughes SK, Oudin MJ, Tadros J, Neil J, Del Rosario A, Joughin BA, Ritsma L, Wyckoff J, Vasile E, Eddy R, Philippar U, Lussiez A, Condeelis JS, van Rheenen J, White F, Lauffenburger DA, Gertler FB.

Mol Biol Cell. 2015 Nov 1;26(21):3867-78. doi: 10.1091/mbc.E15-06-0442. Epub 2015 Sep 2.


The AXL Receptor is a Sensor of Ligand Spatial Heterogeneity.

Meyer AS, Zweemer AJ, Lauffenburger DA.

Cell Syst. 2015 Jul 29;1(1):25-36.


Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells.

Arnold KB, Burgener A, Birse K, Romas L, Dunphy LJ, Shahabi K, Abou M, Westmacott GR, McCorrister S, Kwatampora J, Nyanga B, Kimani J, Masson L, Liebenberg LJ, Abdool Karim SS, Passmore JS, Lauffenburger DA, Kaul R, McKinnon LR.

Mucosal Immunol. 2015 Jun 24. doi: 10.1038/mi.2015.51. [Epub ahead of print]


Molecular Signatures of Immune Activation and Epithelial Barrier Remodeling Are Enhanced during the Luteal Phase of the Menstrual Cycle: Implications for HIV Susceptibility.

Birse K, Arnold KB, Novak RM, McCorrister S, Shaw S, Westmacott GR, Ball TB, Lauffenburger DA, Burgener A.

J Virol. 2015 Sep;89(17):8793-805. doi: 10.1128/JVI.00756-15. Epub 2015 Jun 17.


Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function.

Travers T, Shao H, Joughin BA, Lauffenburger DA, Wells A, Camacho CJ.

Sci Signal. 2015 May 26;8(378):ra51. doi: 10.1126/scisignal.aaa1977.


Identification of drug-specific pathways based on gene expression data: application to drug induced lung injury.

Melas IN, Sakellaropoulos T, Iorio F, Alexopoulos LG, Loh WY, Lauffenburger DA, Saez-Rodriguez J, Bai JP.

Integr Biol (Camb). 2015 Aug;7(8):904-20. doi: 10.1039/c4ib00294f.


Genital inflammation and the risk of HIV acquisition in women.

Masson L, Passmore JA, Liebenberg LJ, Werner L, Baxter C, Arnold KB, Williamson C, Little F, Mansoor LE, Naranbhai V, Lauffenburger DA, Ronacher K, Walzl G, Garrett NJ, Williams BL, Couto-Rodriguez M, Hornig M, Lipkin WI, Grobler A, Abdool Karim Q, Abdool Karim SS.

Clin Infect Dis. 2015 Jul 15;61(2):260-9. doi: 10.1093/cid/civ298. Epub 2015 Apr 21.


Differential levels of soluble inflammatory markers by human immunodeficiency virus controller status and demographics.

Li JZ, Arnold KB, Lo J, Dugast AS, Plants J, Ribaudo HJ, Cesa K, Heisey A, Kuritzkes DR, Lauffenburger DA, Alter G, Landay A, Grinspoon S, Pereyra F.

Open Forum Infect Dis. 2015 Jan 13;2(1):ofu117. doi: 10.1093/ofid/ofu117. eCollection 2015 Jan.


High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation.

Wu L, Claas AM, Sarkar A, Lauffenburger DA, Han J.

Integr Biol (Camb). 2015 May;7(5):513-24. doi: 10.1039/c5ib00019j. Epub 2015 Apr 2.


ADAM8 as a drug target in pancreatic cancer.

Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia AM, Höfling S, Parsons M, Costa P, Soper R, Bossard M, Hagemann T, Roshani R, Sewald N, Ketchem RR, Moss ML, Rasmussen FH, Miller MA, Lauffenburger DA, Tuveson DA, Nimsky C, Bartsch JW.

Nat Commun. 2015 Jan 28;6:6175. doi: 10.1038/ncomms7175.


Low-volume multiplexed proteolytic activity assay and inhibitor analysis through a pico-injector array.

Ng EX, Miller MA, Jing T, Lauffenburger DA, Chen CH.

Lab Chip. 2015 Feb 21;15(4):1153-9. doi: 10.1039/c4lc01162g.


Innovation and insight in integrative biology.

Lauffenburger DA.

Integr Biol (Camb). 2015 Jan;7(1):9. doi: 10.1039/c4ib90047b. No abstract available.

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