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Results: 1 to 20 of 105

1.

The Parkinson's Disease Mutant E46K Enhances Alpha-Synuclein Phosphorylation in Mammalian Cell-Lines, in Yeast and In Vivo.

Mbefo M, Fares MB, Paleologou K, Oueslati A, Yin G, Tenreiro S, Pinto M, Outeiro T, Zweckstetter M, Masliah E, Lashuel HA.

J Biol Chem. 2015 Feb 5. pii: jbc.M114.610774. [Epub ahead of print]

2.

Influence of the β-Sheet Content on the Mechanical Properties of Aggregates during Amyloid Fibrillization.

Ruggeri FS, Adamcik J, Jeong JS, Lashuel HA, Mezzenga R, Dietler G.

Angew Chem Int Ed Engl. 2015 Feb 16;54(8):2462-6. doi: 10.1002/anie.201409050. Epub 2015 Jan 14.

PMID:
25588987
3.

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease.

Eleuteri S, Di Giovanni S, Rockenstein E, Mante M, Adame A, Trejo M, Wrasidlo W, Wu F, Fraering PC, Masliah E, Lashuel HA.

Neurobiol Dis. 2015 Feb;74:144-57. doi: 10.1016/j.nbd.2014.08.017. Epub 2014 Aug 28.

PMID:
25173807
4.

The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.

Khalaf O, Fauvet B, Oueslati A, Dikiy I, Mahul-Mellier AL, Ruggeri FS, Mbefo MK, Vercruysse F, Dietler G, Lee SJ, Eliezer D, Lashuel HA.

J Biol Chem. 2014 Aug 8;289(32):21856-76. doi: 10.1074/jbc.M114.553297. Epub 2014 Jun 16.

PMID:
24936070
5.

The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.

Fares MB, Ait-Bouziad N, Dikiy I, Mbefo MK, Jovičić A, Kiely A, Holton JL, Lee SJ, Gitler AD, Eliezer D, Lashuel HA.

Hum Mol Genet. 2014 Sep 1;23(17):4491-509. doi: 10.1093/hmg/ddu165. Epub 2014 Apr 11.

PMID:
24728187
6.

One-pot semisynthesis of exon 1 of the Huntingtin protein: new tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease.

Ansaloni A, Wang ZM, Jeong JS, Ruggeri FS, Dietler G, Lashuel HA.

Angew Chem Int Ed Engl. 2014 Feb 10;53(7):1928-33. doi: 10.1002/anie.201307510. Epub 2014 Jan 20. Erratum in: Angew Chem Int Ed Engl. 2014 Jul 14;53(29):7389.

PMID:
24446188
7.

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.

Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S, Lamontanara AJ, Bisquertt A, Eliezer D, Masliah E, Halliday G, Hantschel O, Lashuel HA.

Hum Mol Genet. 2014 Jun 1;23(11):2858-79. doi: 10.1093/hmg/ddt674. Epub 2014 Jan 9.

PMID:
24412932
8.

Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice.

Fournier M, Roux A, Garrigue J, Muriel MP, Blanche P, Lashuel HA, Anderson JP, Barbour R, Huang J, du Montcel ST, Brice A, Corti O.

BMC Neurosci. 2013 Nov 5;14:135. doi: 10.1186/1471-2202-14-135.

9.

Real-time amyloid aggregation monitoring with a photonic crystal-based approach.

Santi S, Musi V, Descrovi E, Paeder V, Di Francesco J, Hvozdara L, van der Wal P, Lashuel HA, Pastore A, Neier R, Herzig HP.

Chemphyschem. 2013 Oct 21;14(15):3476-82. doi: 10.1002/cphc.201300633. Epub 2013 Sep 17.

PMID:
24105966
10.

Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology.

Haj-Yahya M, Fauvet B, Herman-Bachinsky Y, Hejjaoui M, Bavikar SN, Karthikeyan SV, Ciechanover A, Lashuel HA, Brik A.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17726-31. doi: 10.1073/pnas.1315654110. Epub 2013 Sep 16.

11.

One-pot total chemical synthesis of human α-synuclein.

Fauvet B, Butterfield SM, Fuks J, Brik A, Lashuel HA.

Chem Commun (Camb). 2013 Oct 18;49(81):9254-6. doi: 10.1039/c3cc45353g.

PMID:
23995579
12.

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo.

Oueslati A, Schneider BL, Aebischer P, Lashuel HA.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):E3945-54. doi: 10.1073/pnas.1309991110. Epub 2013 Aug 27.

13.

Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson disease and other synucleinopathies.

Schmid AW, Fauvet B, Moniatte M, Lashuel HA.

Mol Cell Proteomics. 2013 Dec;12(12):3543-58. doi: 10.1074/mcp.R113.032730. Epub 2013 Aug 21. Review.

14.

Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.

Schildknecht S, Gerding HR, Karreman C, Drescher M, Lashuel HA, Outeiro TF, Di Monte DA, Leist M.

J Neurochem. 2013 May;125(4):491-511. doi: 10.1111/jnc.12226. Epub 2013 Mar 19. Review.

PMID:
23452040
15.

Novel mechanistic insight into the molecular basis of amyloid polymorphism and secondary nucleation during amyloid formation.

Jeong JS, Ansaloni A, Mezzenga R, Lashuel HA, Dietler G.

J Mol Biol. 2013 May 27;425(10):1765-81. doi: 10.1016/j.jmb.2013.02.005. Epub 2013 Feb 13.

PMID:
23415897
16.

The many faces of α-synuclein: from structure and toxicity to therapeutic target.

Lashuel HA, Overk CR, Oueslati A, Masliah E.

Nat Rev Neurosci. 2013 Jan;14(1):38-48. doi: 10.1038/nrn3406.

17.

Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity.

Wang ZM, Lashuel HA.

Angew Chem Int Ed Engl. 2013 Jan 7;52(2):562-7. doi: 10.1002/anie.201206561. Epub 2012 Nov 12.

PMID:
23148019
18.

The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation.

Shabek N, Herman-Bachinsky Y, Buchsbaum S, Lewinson O, Haj-Yahya M, Hejjaoui M, Lashuel HA, Sommer T, Brik A, Ciechanover A.

Mol Cell. 2012 Oct 12;48(1):87-97. doi: 10.1016/j.molcel.2012.07.011. Epub 2012 Aug 16.

19.

Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation.

Kroth H, Ansaloni A, Varisco Y, Jan A, Sreenivasachary N, Rezaei-Ghaleh N, Giriens V, Lohmann S, López-Deber MP, Adolfsson O, Pihlgren M, Paganetti P, Froestl W, Nagel-Steger L, Willbold D, Schrader T, Zweckstetter M, Pfeifer A, Lashuel HA, Muhs A.

J Biol Chem. 2012 Oct 5;287(41):34786-800. doi: 10.1074/jbc.M112.357665. Epub 2012 Aug 13.

20.
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