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Results: 1 to 20 of 218

1.

Adenosine 2A receptor occupancy by tozadenant and preladenant in rhesus monkeys.

Barret O, Hannestad J, Alagille D, Vala C, Tavares A, Papin C, Morley T, Fowles K, Lee H, Seibyl J, Tytgat D, Laruelle M, Tamagnan G.

J Nucl Med. 2014 Oct;55(10):1712-8. doi: 10.2967/jnumed.114.142067. Epub 2014 Jul 31.

PMID:
25082853
[PubMed - indexed for MEDLINE]
2.

Unexpectedly high affinity of a novel histamine H(3) receptor antagonist, GSK239512, in vivo in human brain, determined using PET.

Ashworth S, Berges A, Rabiner EA, Wilson AA, Comley RA, Lai RY, Boardley R, Searle G, Gunn RN, Laruelle M, Cunningham VJ.

Br J Pharmacol. 2014 Mar;171(5):1241-9. doi: 10.1111/bph.12505.

PMID:
24670146
[PubMed - indexed for MEDLINE]
3.

Schizophrenia: from dopaminergic to glutamatergic interventions.

Laruelle M.

Curr Opin Pharmacol. 2014 Feb;14:97-102. doi: 10.1016/j.coph.2014.01.001. Epub 2014 Feb 11. Review.

PMID:
24524997
[PubMed - indexed for MEDLINE]
4.

Relationship between glycine transporter 1 inhibition as measured with positron emission tomography and changes in cognitive performances in nonhuman primates.

Castner SA, Murthy NV, Ridler K, Herdon H, Roberts BM, Weinzimmer DP, Huang Y, Zheng MQ, Rabiner EA, Gunn RN, Carson RE, Williams GV, Laruelle M.

Neuropsychopharmacology. 2014 Nov;39(12):2742-9. doi: 10.1038/npp.2014.4. Epub 2014 Feb 3.

PMID:
24487737
[PubMed - in process]
5.

D-dimer cut-off adjusted to age performs better for exclusion of pulmonary embolism in patients over 75 years.

Laruelle M, Descamps OS, Lesage V.

Acta Clin Belg. 2013 Jul-Aug;68(4):298-302.

PMID:
24455801
[PubMed - indexed for MEDLINE]
6.

Characterising the plasma-target occupancy relationship of the neurokinin antagonist GSK1144814 with PET.

Ridler K, Gunn RN, Searle GE, Barletta J, Passchier J, Dixson L, Hallett WA, Ashworth S, Gray FA, Burgess C, Poggesi I, Bullman JN, Ratti E, Laruelle MA, Rabiner EA.

J Psychopharmacol. 2014 Mar;28(3):244-53. doi: 10.1177/0269881113517953. Epub 2014 Jan 15.

PMID:
24429221
[PubMed - indexed for MEDLINE]
7.

Clinical doses of atomoxetine significantly occupy both norepinephrine and serotonin transports: Implications on treatment of depression and ADHD.

Ding YS, Naganawa M, Gallezot JD, Nabulsi N, Lin SF, Ropchan J, Weinzimmer D, McCarthy TJ, Carson RE, Huang Y, Laruelle M.

Neuroimage. 2014 Feb 1;86:164-71. doi: 10.1016/j.neuroimage.2013.08.001. Epub 2013 Aug 9.

PMID:
23933039
[PubMed - indexed for MEDLINE]
8.

The second revision of the dopamine theory of schizophrenia: implications for treatment and drug development.

Laruelle M.

Biol Psychiatry. 2013 Jul 15;74(2):80-1. doi: 10.1016/j.biopsych.2013.05.016. No abstract available.

PMID:
23809260
[PubMed - indexed for MEDLINE]
9.

Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography.

Comley RA, Salinas CA, Slifstein M, Petrone M, Marzano C, Bennacef I, Shotbolt P, Van der Aart J, Neve M, Iavarone L, Gomeni R, Laruelle M, Gray FA, Gunn RN, Rabiner EA.

J Pharmacol Exp Ther. 2013 Aug;346(2):311-7. doi: 10.1124/jpet.112.202895. Epub 2013 May 17.

PMID:
23685546
[PubMed - indexed for MEDLINE]
Free Article
10.

Mathematical modelling of [¹¹C]-(+)-PHNO human competition studies.

Searle GE, Beaver JD, Tziortzi A, Comley RA, Bani M, Ghibellini G, Merlo-Pich E, Rabiner EA, Laruelle M, Gunn RN.

Neuroimage. 2013 Mar;68:119-32. doi: 10.1016/j.neuroimage.2012.11.033. Epub 2012 Nov 30.

PMID:
23207573
[PubMed - indexed for MEDLINE]
11.

Imaging changes in synaptic acetylcholine availability in living human subjects.

Esterlis I, Hannestad JO, Bois F, Sewell RA, Tyndale RF, Seibyl JP, Picciotto MR, Laruelle M, Carson RE, Cosgrove KP.

J Nucl Med. 2013 Jan;54(1):78-82. doi: 10.2967/jnumed.112.111922. Epub 2012 Nov 15.

PMID:
23160789
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction.

Nathan PJ, Watson J, Lund J, Davies CH, Peters G, Dodds CM, Swirski B, Lawrence P, Bentley GD, O'Neill BV, Robertson J, Watson S, Jones GA, Maruff P, Croft RJ, Laruelle M, Bullmore ET.

Int J Neuropsychopharmacol. 2013 May;16(4):721-31. doi: 10.1017/S1461145712000752. Epub 2012 Aug 29.

PMID:
22932339
[PubMed - indexed for MEDLINE]
13.

Synthesis and characterization of two PET radioligands for the metabotropic glutamate 1 (mGlu1) receptor.

Huang Y, Narendran R, Bischoff F, Guo N, Bae SA, Hwang DR, Lesage AS, Laruelle M.

Synapse. 2012 Dec;66(12):1002-14. doi: 10.1002/syn.21606. Epub 2012 Sep 29. Erratum in: Synapse. 2013 Feb;67(2):109.

PMID:
22927303
[PubMed - indexed for MEDLINE]
14.

Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [¹¹C]DASB and [¹¹C]MDL 100907.

Urban NB, Girgis RR, Talbot PS, Kegeles LS, Xu X, Frankle WG, Hart CL, Slifstein M, Abi-Dargham A, Laruelle M.

Neuropsychopharmacology. 2012 May;37(6):1465-73. doi: 10.1038/npp.2011.332. Epub 2012 Feb 22.

PMID:
22353758
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Computerized cognitive remediation training for schizophrenia: an open label, multi-site, multinational methodology study.

Murthy NV, Mahncke H, Wexler BE, Maruff P, Inamdar A, Zucchetto M, Lund J, Shabbir S, Shergill S, Keshavan M, Kapur S, Laruelle M, Alexander R.

Schizophr Res. 2012 Aug;139(1-3):87-91. doi: 10.1016/j.schres.2012.01.042. Epub 2012 Feb 18.

PMID:
22342330
[PubMed - indexed for MEDLINE]
16.

Combining PET biodistribution and equilibrium dialysis assays to assess the free brain concentration and BBB transport of CNS drugs.

Gunn RN, Summerfield SG, Salinas CA, Read KD, Guo Q, Searle GE, Parker CA, Jeffrey P, Laruelle M.

J Cereb Blood Flow Metab. 2012 May;32(5):874-83. doi: 10.1038/jcbfm.2012.1. Epub 2012 Jan 25.

PMID:
22274741
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Radiosynthesis and characterization of 11C-GSK215083 as a PET radioligand for the 5-HT6 receptor.

Parker CA, Gunn RN, Rabiner EA, Slifstein M, Comley R, Salinas C, Johnson CN, Jakobsen S, Houle S, Laruelle M, Cunningham VJ, Martarello L.

J Nucl Med. 2012 Feb;53(2):295-303. doi: 10.2967/jnumed.111.093419. Epub 2012 Jan 5.

PMID:
22223878
[PubMed - indexed for MEDLINE]
Free Article
18.

Affinity and selectivity of [¹¹C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo.

Gallezot JD, Beaver JD, Gunn RN, Nabulsi N, Weinzimmer D, Singhal T, Slifstein M, Fowles K, Ding YS, Huang Y, Laruelle M, Carson RE, Rabiner EA.

Synapse. 2012 Jun;66(6):489-500. doi: 10.1002/syn.21535. Epub 2012 Feb 24.

PMID:
22213512
[PubMed - indexed for MEDLINE]
19.

The 5-HT(2A) receptor and serotonin transporter in Asperger's disorder: A PET study with [¹¹C]MDL 100907 and [¹¹C]DASB.

Girgis RR, Slifstein M, Xu X, Frankle WG, Anagnostou E, Wasserman S, Pepa L, Kolevzon A, Abi-Dargham A, Laruelle M, Hollander E.

Psychiatry Res. 2011 Dec 30;194(3):230-4. doi: 10.1016/j.pscychresns.2011.04.007. Epub 2011 Nov 12.

PMID:
22079057
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Biodistribution and radiation dosimetry of the serotonin 5-HT₆ ligand [¹¹C]GSK215083 determined from human whole-body PET.

Comley RA, Salinas C, Mizrahi R, Vitcu I, Ng A, Hallett W, Keat N, Wilson AA, Rabiner EA, Laruelle M, Houle S.

Mol Imaging Biol. 2012 Aug;14(4):517-21. doi: 10.1007/s11307-011-0523-1.

PMID:
22076076
[PubMed - indexed for MEDLINE]

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