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Items: 1 to 20 of 152


SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery.

Saxena N, Maio N, Crooks DR, Ricketts CJ, Yang Y, Wei MH, Fan TW, Lane AN, Sourbier C, Singh A, Killian JK, Meltzer PS, Vocke CD, Rouault TA, Linehan WM.

J Natl Cancer Inst. 2015 Oct 12;108(1). pii: djv287. doi: 10.1093/jnci/djv287.


Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype.

Liu M, Luo F, Ding C, Albeituni S, Hu X, Ma Y, Cai Y, McNally L, Sanders MA, Jain D, Kloecker G, Bousamra M 2nd, Zhang HG, Higashi RM, Lane AN, Fan TW, Yan J.

J Immunol. 2015 Nov 15;195(10):5055-65. doi: 10.4049/jimmunol.1501158. Epub 2015 Oct 9.


Regulation of mammalian nucleotide metabolism and biosynthesis.

Lane AN, Fan TW.

Nucleic Acids Res. 2015 Feb 27;43(4):2466-85. doi: 10.1093/nar/gkv047. Epub 2015 Jan 27. Review.


Chemoselective detection and discrimination of carbonyl-containing compounds in metabolite mixtures by 1H-detected 15N nuclear magnetic resonance.

Lane AN, Arumugam S, Lorkiewicz PK, Higashi RM, Laulhé S, Nantz MH, Moseley HN, Fan TW.

Magn Reson Chem. 2015 May;53(5):337-43. doi: 10.1002/mrc.4199. Epub 2015 Jan 23.


Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation.

Sellers K, Fox MP, Bousamra M 2nd, Slone SP, Higashi RM, Miller DM, Wang Y, Yan J, Yuneva MO, Deshpande R, Lane AN, Fan TW.

J Clin Invest. 2015 Feb;125(2):687-98. doi: 10.1172/JCI72873. Epub 2015 Jan 20.


Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS.

Higashi RM, Fan TW, Lorkiewicz PK, Moseley HN, Lane AN.

Methods Mol Biol. 2014;1198:147-67. doi: 10.1007/978-1-4939-1258-2_11.


Development and in silico evaluation of large-scale metabolite identification methods using functional group detection for metabolomics.

Mitchell JM, Fan TW, Lane AN, Moseley HN.

Front Genet. 2014 Jul 28;5:237. doi: 10.3389/fgene.2014.00237. eCollection 2014.


Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling.

Ren JG, Seth P, Clish CB, Lorkiewicz PK, Higashi RM, Lane AN, Fan TW, Sukhatme VP.

Sci Rep. 2014 Jun 24;4:5414. doi: 10.1038/srep05414.


Structural insights into the evolution of a sexy protein: novel topology and restricted backbone flexibility in a hypervariable pheromone from the red-legged salamander, Plethodon shermani.

Wilburn DB, Bowen KE, Doty KA, Arumugam S, Lane AN, Feldhoff PW, Feldhoff RC.

PLoS One. 2014 May 21;9(5):e96975. doi: 10.1371/journal.pone.0096975. eCollection 2014.


Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

Xie H, Hanai J, Ren JG, Kats L, Burgess K, Bhargava P, Signoretti S, Billiard J, Duffy KJ, Grant A, Wang X, Lorkiewicz PK, Schatzman S, Bousamra M 2nd, Lane AN, Higashi RM, Fan TW, Pandolfi PP, Sukhatme VP, Seth P.

Cell Metab. 2014 May 6;19(5):795-809. doi: 10.1016/j.cmet.2014.03.003. Epub 2014 Apr 10.


Role in tumor growth of a glycogen debranching enzyme lost in glycogen storage disease.

Guin S, Pollard C, Ru Y, Ritterson Lew C, Duex JE, Dancik G, Owens C, Spencer A, Knight S, Holemon H, Gupta S, Hansel D, Hellerstein M, Lorkiewicz P, Lane AN, Fan TW, Theodorescu D.

J Natl Cancer Inst. 2014 Apr 3;106(5). pii: dju062. doi: 10.1093/jnci/dju062.


Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma.

Yang Y, Lane AN, Ricketts CJ, Sourbier C, Wei MH, Shuch B, Pike L, Wu M, Rouault TA, Boros LG, Fan TW, Linehan WM.

PLoS One. 2013 Aug 15;8(8):e72179. doi: 10.1371/journal.pone.0072179. eCollection 2013.


Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection.

Buscaglia R, Miller MC, Dean WL, Gray RD, Lane AN, Trent JO, Chaires JB.

Nucleic Acids Res. 2013 Sep;41(16):7934-46. doi: 10.1093/nar/gkt440. Epub 2013 Jun 26.


Control of glutamine metabolism by the tumor suppressor Rb.

Reynolds MR, Lane AN, Robertson B, Kemp S, Liu Y, Hill BG, Dean DC, Clem BF.

Oncogene. 2014 Jan 30;33(5):556-66. doi: 10.1038/onc.2012.635. Epub 2013 Jan 28.


High information throughput analysis of nucleotides and their isotopically enriched isotopologues by direct-infusion FTICR-MS.

Lorkiewicz P, Higashi RM, Lane AN, Fan TW.

Metabolomics. 2012;8(5):930-939. Epub 2011 Dec 9.


Administration of exogenous adenosine triphosphate to ischemic skeletal muscle induces an energy-sparing effect: role of adenosine receptors.

Maldonado C, Pushpakumar SB, Perez-Abadia G, Arumugam S, Lane AN.

J Surg Res. 2013 May 1;181(1):e15-22. doi: 10.1016/j.jss.2012.06.033. Epub 2012 Jul 6.


Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.

Liu W, Le A, Hancock C, Lane AN, Dang CV, Fan TW, Phang JM.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8983-8. doi: 10.1073/pnas.1203244109. Epub 2012 May 21.


Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.

Le A, Lane AN, Hamaker M, Bose S, Gouw A, Barbi J, Tsukamoto T, Rojas CJ, Slusher BS, Zhang H, Zimmerman LJ, Liebler DC, Slebos RJ, Lorkiewicz PK, Higashi RM, Fan TW, Dang CV.

Cell Metab. 2012 Jan 4;15(1):110-21. doi: 10.1016/j.cmet.2011.12.009.

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