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cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and τ.

Fernandez-Leiro R, Conrad J, Scheres SH, Lamers MH.

Elife. 2015 Oct 24;4. pii: e11134. doi: 10.7554/eLife.11134.


Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.

Aibara S, Valkov E, Lamers MH, Dimitrova L, Hurt E, Stewart M.

Acta Crystallogr F Struct Biol Commun. 2015 Jul;71(Pt 7):876-88. doi: 10.1107/S2053230X15008766. Epub 2015 Jun 27.


DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader.

Rock JM, Lang UF, Chase MR, Ford CB, Gerrick ER, Gawande R, Coscolla M, Gagneux S, Fortune SM, Lamers MH.

Nat Genet. 2015 Jun;47(6):677-81. doi: 10.1038/ng.3269. Epub 2015 Apr 20.


Aminoadamantanes versus other antiviral drugs for chronic hepatitis C.

Lamers MH, Broekman M, Drenth JP, Gluud C.

Cochrane Database Syst Rev. 2014 Jun 17;6:CD011132. doi: 10.1002/14651858.CD011132.pub2. Review.


Aminoadamantanes for chronic hepatitis C.

Lamers MH, Broekman M, Drenth JP, Gluud C.

Cochrane Database Syst Rev. 2014 May 3;5:CD010125. doi: 10.1002/14651858.CD010125.pub2. Review.


Treatment of hepatitis C monoinfection in adults--Dutch national guidelines.

Lamers MH, Broekman MM, Boucher CA, Brouwer JT, Burger DM, van Hoek B, Hoepelman AI, de Knegt RJ, Reesink HW, Drenth JP; Netherlands Association of Hepato-gastroenterologists; Netherlands Association of Internal Medicine; Dutch Association for the Study of Liver Disease.

Neth J Med. 2013 Sep;71(7):377-85.


Hekate: software suite for the mass spectrometric analysis and three-dimensional visualization of cross-linked protein samples.

Holding AN, Lamers MH, Stephens E, Skehel JM.

J Proteome Res. 2013 Dec 6;12(12):5923-33. doi: 10.1021/pr4003867. Epub 2013 Oct 4.


A structural role for the PHP domain in E. coli DNA polymerase III.

Barros T, Guenther J, Kelch B, Anaya J, Prabhakar A, O'Donnell M, Kuriyan J, Lamers MH.

BMC Struct Biol. 2013 May 14;13:8. doi: 10.1186/1472-6807-13-8.


Architecture of the Pol III-clamp-exonuclease complex reveals key roles of the exonuclease subunit in processive DNA synthesis and repair.

Toste Rêgo A, Holding AN, Kent H, Lamers MH.

EMBO J. 2013 May 2;32(9):1334-43. doi: 10.1038/emboj.2013.68. Epub 2013 Apr 2.


ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes.

Hadders MA, Agromayor M, Obita T, Perisic O, Caballe A, Kloc M, Lamers MH, Williams RL, Martin-Serrano J.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17424-9. doi: 10.1073/pnas.1206839109. Epub 2012 Oct 8.


Interferon-α for patients with chronic hepatitis delta: a systematic review of randomized clinical trials.

Lamers MH, Kirgiz ÖÖ, Heidrich B, Wedemeyer H, Drenth JP.

Antivir Ther. 2012;17(6):1029-37. doi: 10.3851/IMP2306. Epub 2012 Aug 15. Review.


Hepatitis C virus infection management in 2012.

Van Gulick JJ, Lamers MH, Drenth JP.

Panminerva Med. 2012 Mar;54(1):1-9. Review.


Treatment of Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker.

Goldberg YP, Price N, Namdari R, Cohen CJ, Lamers MH, Winters C, Price J, Young CE, Verschoof H, Sherrington R, Pimstone SN, Hayden MR.

Pain. 2012 Jan;153(1):80-5. doi: 10.1016/j.pain.2011.09.008. Epub 2011 Oct 28.


Current clinical care compared with new Dutch guidelines for hepatitis C treatment.

Slavenburg S, Lamers MH, Roomer R, de Knegt RJ, van Oijen MG, Drenth JP.

Neth J Med. 2009 May;67(5):177-81.


Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.

Jura N, Endres NF, Engel K, Deindl S, Das R, Lamers MH, Wemmer DE, Zhang X, Kuriyan J.

Cell. 2009 Jun 26;137(7):1293-307. doi: 10.1016/j.cell.2009.04.025. Erratum in: Cell. 2009 Aug 7;138(3):604.


A consensus view of DNA binding by the C family of replicative DNA polymerases.

Lamers MH, O'Donnell M.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20565-6. doi: 10.1073/pnas.0811279106. Epub 2008 Dec 23. No abstract available.


Structure and regulatory mechanism of Aquifex aeolicus NtrC4: variability and evolution in bacterial transcriptional regulation.

Batchelor JD, Doucleff M, Lee CJ, Matsubara K, De Carlo S, Heideker J, Lamers MH, Pelton JG, Wemmer DE.

J Mol Biol. 2008 Dec 31;384(5):1058-75. doi: 10.1016/j.jmb.2008.10.024. Epub 2008 Oct 17.


The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase.

Winger JA, Derbyshire ER, Lamers MH, Marletta MA, Kuriyan J.

BMC Struct Biol. 2008 Oct 7;8:42. doi: 10.1186/1472-6807-8-42.


Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III.

Lamers MH, Georgescu RE, Lee SG, O'Donnell M, Kuriyan J.

Cell. 2006 Sep 8;126(5):881-92.


ATP increases the affinity between MutS ATPase domains. Implications for ATP hydrolysis and conformational changes.

Lamers MH, Georgijevic D, Lebbink JH, Winterwerp HH, Agianian B, de Wind N, Sixma TK.

J Biol Chem. 2004 Oct 15;279(42):43879-85. Epub 2004 Aug 4.

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