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Results: 1 to 20 of 31

1.

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.

Smith JJ, Kenney RD, Gagne DJ, Frushour BP, Ladd W, Galonek HL, Israelian K, Song J, Razvadauskaite G, Lynch AV, Carney DP, Johnson RJ, Lavu S, Iffland A, Elliott PJ, Lambert PD, Elliston KO, Jirousek MR, Milne JC, Boss O.

BMC Syst Biol. 2009 Mar 10;3:31. doi: 10.1186/1752-0509-3-31.

PMID:
19284563
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.

Vu CB, Bemis JE, Disch JS, Ng PY, Nunes JJ, Milne JC, Carney DP, Lynch AV, Smith JJ, Lavu S, Lambert PD, Gagne DJ, Jirousek MR, Schenk S, Olefsky JM, Perni RB.

J Med Chem. 2009 Mar 12;52(5):1275-83. doi: 10.1021/jm8012954.

PMID:
19199480
[PubMed - indexed for MEDLINE]
3.

Discovery of benzothiazole derivatives as efficacious and enterocyte-specific MTP inhibitors.

Vu CB, Milne JC, Carney DP, Song J, Choy W, Lambert PD, Gagne DJ, Hirsch M, Cote A, Davis M, Lainez E, Meade N, Normington K, Jirousek MR, Perni RB.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1416-20. doi: 10.1016/j.bmcl.2009.01.044. Epub 2009 Jan 19.

PMID:
19181526
[PubMed - indexed for MEDLINE]
4.

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation.

Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, Milne JC, Lambert PD, Mataki C, Elliott PJ, Auwerx J.

Cell Metab. 2008 Nov;8(5):347-58. doi: 10.1016/j.cmet.2008.08.017. Erratum in: Cell Metab. 2009 Feb;9(2):210.

PMID:
19046567
[PubMed - indexed for MEDLINE]
Free Article
5.

Sirtuins--novel therapeutic targets to treat age-associated diseases.

Lavu S, Boss O, Elliott PJ, Lambert PD.

Nat Rev Drug Discov. 2008 Oct;7(10):841-53. doi: 10.1038/nrd2665. Review. Erratum in: Nat Rev Drug Discov. 2009 Jun;8(6):516.

PMID:
18827827
[PubMed - indexed for MEDLINE]
6.

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH.

Nature. 2007 Nov 29;450(7170):712-6.

PMID:
18046409
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Activation of the hypothalamic arcuate nucleus predicts the anorectic actions of ciliary neurotrophic factor and leptin in intact and gold thioglucose-lesioned mice.

Anderson KD, Lambert PD, Corcoran TL, Murray JD, Thabet KE, Yancopoulos GD, Wiegand SJ.

J Neuroendocrinol. 2003 Jul;15(7):649-60.

PMID:
12787049
[PubMed - indexed for MEDLINE]
8.

Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity.

Lambert PD, Anderson KD, Sleeman MW, Wong V, Tan J, Hijarunguru A, Corcoran TL, Murray JD, Thabet KE, Yancopoulos GD, Wiegand SJ.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4652-7. Epub 2001 Mar 20.

PMID:
11259650
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The ciliary neurotrophic factor and its receptor, CNTFR alpha.

Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD, Wiegand SJ.

Pharm Acta Helv. 2000 Mar;74(2-3):265-72. Review.

PMID:
10812968
[PubMed - indexed for MEDLINE]
10.

CART peptide immunoreactivity in the hypothalamus and pituitary in monkeys: analysis of ultrastructural features and synaptic connections in the paraventricular nucleus.

Dall Vechia S, Lambert PD, Couceyro PC, Kuhar MJ, Smith Y.

J Comp Neurol. 2000 Jan 17;416(3):291-308.

PMID:
10602089
[PubMed - indexed for MEDLINE]
11.

Studies of selected phenyltropanes at monoamine transporters.

Kuhar MJ, McGirr KM, Hunter RG, Lambert PD, Garrett BE, Carroll FI.

Drug Alcohol Depend. 1999 Aug 2;56(1):9-15.

PMID:
10462087
[PubMed - indexed for MEDLINE]
12.

Chronic lithium treatment decreases neuronal activity in the nucleus accumbens and cingulate cortex of the rat.

Lambert PD, McGirr KM, Ely TD, Kilts CD, Kuhar MJ.

Neuropsychopharmacology. 1999 Aug;21(2):229-37.

PMID:
10432471
[PubMed - indexed for MEDLINE]
Free Article
13.

CART peptides in the central control of feeding and interactions with neuropeptide Y.

Lambert PD, Couceyro PR, McGirr KM, Dall Vechia SE, Smith Y, Kuhar MJ.

Synapse. 1998 Aug;29(4):293-8.

PMID:
9661247
[PubMed - indexed for MEDLINE]
14.

Cocaine- and amphetamine-regulated transcript peptide immunohistochemical localization in the rat brain.

Koylu EO, Couceyro PR, Lambert PD, Kuhar MJ.

J Comp Neurol. 1998 Feb 2;391(1):115-32.

PMID:
9527537
[PubMed - indexed for MEDLINE]
15.

Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland.

Koylu EO, Couceyro PR, Lambert PD, Ling NC, DeSouza EB, Kuhar MJ.

J Neuroendocrinol. 1997 Nov;9(11):823-33.

PMID:
9419833
[PubMed - indexed for MEDLINE]
16.

Additive effects of lactation and food restriction to increase hypothalamic neuropeptide Y mRNA in rats.

Wilding JP, Ajala MO, Lambert PD, Bloom SR.

J Endocrinol. 1997 Mar;152(3):365-9.

PMID:
9071956
[PubMed - indexed for MEDLINE]
17.

Neurotensin induces Fos and Zif268 expression in limbic nuclei of the rat brain.

Lambert PD, Ely TD, Gross RE, Kilts CD.

Neuroscience. 1996 Dec;75(4):1141-51.

PMID:
8938747
[PubMed - indexed for MEDLINE]
18.

Weight loss in rats treated with intracerebroventricular cobalt protoporphyrin is not specific to the neuropeptide Y system.

Choi SJ, Meeran K, O'Shea D, Lambert PD, Bloom SR.

Brain Res. 1996 Aug 12;729(2):223-7.

PMID:
8876991
[PubMed - indexed for MEDLINE]
19.

Reduced NPY induced feeding in diabetic but not steroid-treated rats: lack of evidence for changes in receptor number or affinity.

Morgan DG, Lambert PD, Smith DM, Wilding JP, Bloom SR.

J Neuroendocrinol. 1996 Apr;8(4):283-90.

PMID:
8861284
[PubMed - indexed for MEDLINE]
20.

A role for glucagon-like peptide-1 in the central regulation of feeding.

Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JP, Smith DM, Ghatei MA, Herbert J, Bloom SR.

Nature. 1996 Jan 4;379(6560):69-72.

PMID:
8538742
[PubMed - indexed for MEDLINE]

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