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Thromb Haemost. 2010 Apr;103(4):736-48. doi: 10.1160/TH09-09-0667. Epub 2010 Feb 2.

Venous thromboembolism risk and prophylaxis in hospitalised medically ill patients. The ENDORSE Global Survey.

Collaborators (369)

Cohen AT, Tapson VF, Bergmann JF, Goldhaber SZ, Kakkar AK, Anderson FA Jr, Cherfi L, Ammour D, Bentakouk C, Bourenane R, Grainat N, Maarouf A, Sissaoui A, Gallus A, Ayyar V, Crimmins D, Gan E, McRae S, Seldon M, Singh B, Siddiqui FM, Moula K, Nawaz T, Nazimuddin K, Rahman S, Sarker S, Rocha A, Brandao C, Costa J, Macedo A, Marino R, Menezes P, Oigman W, Paiva M, Pantoja J, Rocha A, Schramm E, Tandeitnik L, Timi J, Staikov I, Benov H, Borisov SD, Lalov A, Mirazchijski B, Postadziyan A, Sokolov K, Statelov E, Stefanov C, Stoykova A, Tadzher S, Todorov R, Dennis R, Dura FR, Posada JA, Restrepo H, Roa JH, Villadiego J, Maly J, Brabec T, Gumulec J, Jochymek R, Kellnerova I, Kvasnicka J, Penka M, Skarkova J, Slezak P, Vit P, Vojtisek P, Gobran H, El Rahman AM, El Haddad A, Gorgy GS, Rizk-Allah M, Sholkamy S, Bergmann JF, Abinader M, Khoudir FA, Boyer JF, Brun N, Canet B, Collard C, Cordier C, Durroux C, Emmerich J, Friocourt P, Genay P, Ibouanga F, Moumen A, Philippe P, Planchon P, Protin Y, Quere I, Rizcallah MJ, Zotz R, Bensch K, Bensmann K, Dropmann A, Gerold D, Gussmann A, Kortmann B, Kube L, Kuster S, Leupolz W, Neuhaus T, Nobel W, Pfiel S, Pleger E, Trautmann H, Voigt I, Wolf S, Liapis C, Antoniadis P, Arvanitis D, Bakatsglos S, Christakis C, Gerassimidis T, Kostakis A, Losonczy H, Bernath B, Domjan G, Gyani E, Jojart I, Kecskes G, Lakatos J, Ledniczki I, Mayer K, Nyuzo B, Zeher M, Pinjala R, Agnihotri V, Balraj A, Chakraborty A, Desai S, Elangovan A, Goswami P, Rupert E, Toraskar K, Venkatesh K, Gaine S, Connaughton J, Costello R, Liston R, Zubieta RM, Fematt FM, Esponda JA, Maldonado DR, Serrano ME, Perez FE, Montalvo CL, Marquez SL, Sanchez AQ, Diaz SR, Serrano AT, de la Vega MI, Faridi S, Javaid M, Khan F, Malik AZ, Sadiq M, Yusaf-Shah M, Musial J, Biedziuk B, Gellert R, Klonowski W, Kosiniau-Kamysz A, Kuta M, Prajs Z, Sell M, Tadeusz K, Witkiewicz W, Wysota J, Franca A, Abreu R, Campello Mda G, Cartucho D, Lohmann C, Moreira P, Paulino A, Reis A, de Morais ML, de Abreu TT, Tulbure D, Andrei M, Christian P, Ciurea M, Constantin P, Enachescu M, Gostian O, Grintescu IM, Mimor O, Natalia H, Puiac C, Valerica S, Sulimov VA, Belentsov S, Dubrovnaya N, Eliseeva E, Fridman I, Kazantchian P, Mashtacov B, Redkin A, Rodoman G, Shershnev V, Zhidkov K, Gaspar L, Barta P, Benova K, Duris T, Fecik J, Hajas J, Herman O, Lehotsky J, Macek V, Pradova V, Arcelus J, Carrascosa M, Luque RC, Gil Jdel V, de Souza PD, Enfedaque MA, Gonzalo FE, Sanchez FG, Garcia G, Lobo-Beristain JL, Lopez L, Rodriguez JA, Paredes RM, Rodriguez JL, Cantero AR, Lorenzo PR, Legarre AL, Sanchez AC, Cardenas MJ, Bernad RV, Moreno JR, Doerffler J, Beer J, Brunner B, Chopard P, Fischer J, Ludwig C, Peter J, Rime F, Salomon F, Ulrich M, Angchaisuksiri P, Chetanachan M, Chuamuangphan N, Insiripong S, Nawarawong W, Ben Salah A, Ghedira H, Houman MH, Mohamed M, Samir K, Smiti-Khanfir M, Zouheir J, Ongen G, Altintas F, Cirak AK, Demirtas N, Dokucu A, Erden F, Guven H, Halezeroglu S, Karaoglan H, Kaynar L, Tereci H, Yildirim C, Wilmott R, Cohen A, Calvey T, Cohen A, Gallegos N, Gaminara E, James A, Jeffreys M, Jowett N, Keaney N, Kesteven P, Khan Z, Mackie P, Mallick A, Marval P, Parapia L, Picozzi N, Praveen B, Satchi G, Valerio D, Tapson V, Anderson F, Antonacci A, Baker G, Beaver R, Becker W, Beckett C, Borchardt C, Briggs M, Bruckman J, Buck L, Caushaj P, Chausow A, Christopulos D, Cica P, Cody J, Condit B, Cronin S, Cysyk B, Diefendorf A, Driggers S, Ellis P, Elvenia J, Feinbloom D, Feldman M, Fischer M, Froehlich J, Frost C, Gaffey J, Galster R, Geldmeier R, George J, Glielmi V, Goodwin J, Gottlieb A, Gray B, Harrington D, Henry E, Hernandez C, Hill D, Hutchinson M, Johnson J, Johnson R, Kapre S, Kedzie R, Kowaloff H, Krodel J, Lehman J, Marney T, Marshall I, McDaniels M, Middleton R 3rd, Mitchell P, Nelson C, Netherland S, Ogden M, Packard K, Pieske M, Poole L, Radford M, Rathbun S, Roberts C, Robinson M, Rollins D, Rubinate D, Schmidt C, Scott J, Shutt S, Slone B, Spyropoulos A, Subramanian S, Sullivan J, Timmerman C, Vizzard C, Wheeler C, White D, White N, Whitehead A, Wright J, Young D.

Author information

  • 1Hôpital Lariboisière, University Paris 7, Paris, France. jf.bergmann@lrb.aphp.fr

Abstract

Limited data are available regarding the risk for venous thromboembolism (VTE) and VTE prophylaxis use in hospitalised medically ill patients. We analysed data from the global ENDORSE survey to evaluate VTE risk and prophylaxis use in this population according to diagnosis, baseline characteristics, and country. Data on patient characteristics, VTE risk, and prophylaxis use were abstracted from hospital charts. VTE risk and prophylaxis use were evaluated according to the 2004 American College of Chest Physicians (ACCP) guidelines. Multivariable analysis was performed to identify factors associated with use of ACCP-recommended prophylaxis. Data were evaluated for 37,356 hospitalised medical patients across 32 countries. VTE risk varied according to medical diagnosis, from 31.2% of patients with gastrointestinal/hepatobiliary diseases to 100% of patients with acute heart failure, active non-infectious respiratory disease, or pulmonary infection (global rate, 41.5%). Among those at risk for VTE, ACCP-recommended prophylaxis was used in 24.4% haemorrhagic stroke patients and 40-45% of cardiopulmonary disease patients (global rate, 39.5%). Large differences in prophylaxis use were observed among countries. Markers of disease severity, including central venous catheters, mechanical ventilation, and admission to intensive care units, were strongly associated with use of ACCP-recommended prophylaxis. In conclusion, VTE risk varies according to medical diagnosis. Less than 40% of at-risk hospitalised medical patients receive ACCP-recommended prophylaxis. Prophylaxis use appears to be associated with disease severity rather than medical diagnosis. These data support the necessity to improve implementation of available guidelines for evaluating VTE risk and providing prophylaxis to hospitalised medical patients.

PMID:
20135072
[PubMed - indexed for MEDLINE]
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